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The European Physical Journal E

, Volume 29, Issue 3, pp 329–336 | Cite as

Theoretical study of a membrane channel gated by ATP

  • J. G. OrlandiEmail author
  • J. M. Sancho
Regular Article

Abstract

We study channel transport across biomembranes. We propose a model that couples the diffusive dynamics with the gating process via a two-state ratchet mechanism. This gating process is governed by ATP binding and hydrolysis, and the process exhibits Michaelis-Menten enzymatic kinetics. The particle flow and permeability of the channel are studied both analytically and numerically in the steady-state regime, while working between fixed concentrations. The results are compared with simpler models and with experimental data. Also, a simulation framework, that allows high flexibility in parameter exploration, is introduced.

PACS

05.40.-a Fluctuation phenomena, random processes, noise, and Brownian motion 05.70.Ln Nonequilibrium and irreversible thermodynamics 87.16.dp Transport, including channels, pores, and lateral diffusion 

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Copyright information

© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Departament d’Estructura i Constituents de la MatèriaUniversitat de BarcelonaBarcelonaSpain

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