A novel approach to study radiation track structure with nanometer-equivalent resolution

  • Margherita Casiraghi
  • Vladimir Bashkirov
  • Ford Hurley
  • Reinhard Schulte
Regular Article
Part of the following topical collections:
  1. Topical Issue: Nano-scale Insights into Ion-beam Cancer Therapy

Abstract

Clustered DNA damages are considered the critical lesions in the pathways leading from the initial energy deposition by radiation to radiobiological damage. The spatial distribution of the initial DNA damage is mainly determined by radiation track-structure at the nanometer level. In this work, a novel experimental approach to image the three-dimensional structure of micrometric radiation track segments is presented. The approach utilizes the detection of single ions created in low-pressure gas. Ions produced by radiation drift towards a GEM-like 2D hole-pattern detector. When entering individual holes, ions can induce ion-impact ionization of the working-gas starting a confined electron avalanche that generates the output signal. By registering positive ions rather than electrons, diffusion is reduced and a spatial resolution of the track image of the order of water-equivalent nanometers can be achieved. Measurements and simulations to characterize the performance of a few detector designs were performed. Different cathode materials were tested and ionization cluster size distributions of 241Am alpha particles were measured. The electric field configuration in the detector was calculated to optimize the ion focusing into the detector holes. The preliminary results obtained show the directions for further development of the detector.

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Copyright information

© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Margherita Casiraghi
    • 1
  • Vladimir Bashkirov
    • 2
  • Ford Hurley
    • 2
  • Reinhard Schulte
    • 2
    • 3
  1. 1.Center for Proton TherapyPaul Scherrer InstitutVilligen PSISwitzerland
  2. 2.Department of Basic SciencesLoma Linda UniversityLoma LindaUSA
  3. 3.Department of Radiation MedicineLoma Linda University Medical CenterLoma LindaUSA

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