Characterizing neuromorphologic alterations with additive shape functionals

  • M. S. Barbosa
  • L. da F. Costa
  • E. S. Bernardes
  • G. Ramakers
  • J. van Pelt


The complexity of a neuronal cell shape is known to be related to its function. Specifically, among other indicators, a decreased complexity in the dendritic trees of cortical pyramidal neurons has been associated with mental retardation. In this paper we develop a procedure to address the characterization of morphological changes induced in cultured neurons by over-expressing a gene involved in mental retardation. Measures associated with the multiscale connectivity, an additive image functional, are found to give a reasonable separation criterion between two categories of cells. One category consists of a control group and two transfected groups of neurons, and the other, a class of cat ganglionary cells. The reported framework also identified a trend towards lower complexity in one of the transfected groups. Such results establish the suggested measures as an effective descriptors of cell shape.


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Copyright information

© EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2004

Authors and Affiliations

  • M. S. Barbosa
    • 1
  • L. da F. Costa
    • 1
  • E. S. Bernardes
    • 2
  • G. Ramakers
    • 3
  • J. van Pelt
    • 3
  1. 1.Cybernetic Vision Research Group, GII-IFSCUniversidade de São PauloSão Carlos, SPBrasil
  2. 2.DFCM-IFSCUniversidade de São PauloSão Carlos, SPBrasil
  3. 3.Neurons and NetworkNetherlands Institute of Brain ResearchAZ AmsterdamThe Netherlands

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