Abstract
The review describes modern concepts of chemical and enzymatic synthesis, isolation from natural sources, and the creation of industrial production technologies phospholipids of various molecular types. Phospholipid structures, biological and physiological activity, pharmacological properties, and the possibility of using them for the liposomal form of the drug preparation are discussed. Biopharmaceutical technologies using phospholipids for the development of a new generation of pharmaceutical formulations are considered. The latest data concerning the application of nanocontainers for loading classic drugs during the design of modern effective drug formulations are reported. These formulations are used to improve results of treatment, to provide the targeted drug delivery into pathological foci, to prolong the action time, and to increase the drug solubility. Among the aforementioned containers, special emphasis should be given to liposomes, nanosomal polymeric formulations based on polybutylcyanoacrylates or on polylactides, and spherical amorphous nanoparticles formed from birch bark triterpenoids. The results of studies of their biological and pharmaceutical properties are reported. The present state of the art is also presented.
Similar content being viewed by others
References
“Farmatsevtika. Meditsinskaya promyshlennost’. Biotekhnologiya”. Mezhdunarodnyi forum (“Pharmaceuticals. Medical industry. Biotechnology:” International Forum), St. Petersburg, 2012.
Evstigneeva, R.P., Zvonkova, E.N., Serebrennikova, G.A., and Shvets, V.I., Khimiya lipidov (Lipid Chemistry), Moscow: Khimiya, 1983.
Stepanov, A.E., Krasnopol’skii, Yu.M., and Shvets, V.I., Fiziologicheski aktivnye lipidy (Physiologically Active Lipids), Moscow: Nauka, 1991.
Dudnichenko, A.S., Krasnopol’skii, Yu.M., and Shvets, V.I., Liposomal’nye lekarstvennye preparaty v eksperimente i klinike (Liposomal Drugs in Experiments and Clinical Practice), Kharkov: RA-Karavella, 2001.
Shvets, V.I., Stepanov, A.E., Krylova, V.N., and Gulak, P.V., Mio-inozit i fosfoinozitidy (Myo-Inositol and Phosphoinositides), Moscow: Nauka, 1987.
Shvets, V.I., Klyashchitskii, B.A., Stepanov, A.E., and Evstigneeva, R.P., Tetrahedron, 1973, vol. 29, no. 6, p. 331.
Stepanov, A.E. and Shvets, V.I., Chem. Phys. Lipids, 1986, vol. 41, no. 1, p. 1.
Shvets, V.I., Stepanov, A.E., Schmitt, L., Spiess, B., and Schlever, G., Inositol Phosphates and Derivatives: Synthesis, Biochemistry and Therapeutic Potential, Reitz, A.B., Ed., Washington: ACS Symposium Series 463, 1991, p. 155.
Stepanov, A.E. and Shvets, V.I., Phosphoinositides. Chemistry, Biochemistry and Biomedical Applications, Bruzik, K.S., Ed., Washington: ACS Symposium Series 718, 1999, p. 244.
Zamyatina, A.Yu. and Shvets, V.I., Chem. Phys. Lipids, 1995, vol. 7, no. 3, p. 225.
Bogomolov, O.V., Kaplun, A.P., and Shvets, V.I., Usp. Khim., 1988, vol. 57, no. 4, p. 684.
Kaplun, A.P., Bogomolov, O.V., Yakunina, N.B., Kuzmina, Yu.V., and Shvets, V.I., Chem. Phys. Lipids, 1998, vol. 94, no. 3, p. 193.
Kaplun, A.P., Yakunina, N.B., and Shvets, V.I., Bioorg. Khim., 1992, vol. 18, no. 4, p. 584.
Oskolkova, O.V., Hermetler, A., Paltauf, F., and Shvets, V.I., Chem. Phys. Lipids, 1999, vol. 99, no. 1, p. 73.
Ugol’nikova, O.A., Demich, Yu.A., Lisitsa, A.V., Kistanova, V.Yu., Kornyushko, V.F., Archakov, A.I., and Shvets, V.I., Vestnik MITKhT, 2010, vol. 5, no. 2, p. 91.
Vasilenko, I.A., Krasnopol’skii, Yu.M., Stepanov, A.E., and Shvets, V.I., Khim.-Farm. Zh., 1998, no. 5, p. 9.
Katalog produktsii FGUP Sankt-Peterburgskogo nauchno-issledovatel’skogo instituta vaktsin i syvorotok i predpriyatiya po proizvodstvu bakteriinykh preparatov FMBA Minzdravsotsrazvitiya RF (Product Catalog of Federal State Unitary Enterprise of the St. Petersburg Research Institute of Vaccines and Sera on Production of Bacterial Preparations, Federal Biomedical Agency, Ministry of Health Care and Social Development of the Russian Federation, 2011, p. 31.
Gennis, O.B., Biomembranes: Molecular Structure and Function, New York, 1996.
Killian, J.A., G. van Meer, EMBO Reports, 2001, vol. 21, p. 91.
Sorokoumova, G.M., Vasilenko, I.A., Tarakhovskii, Yu.S., Borovyagin, V.L., and Shvets, V.I., Biol. Membr., 1985, vol. 2, no. 6, p. 649.
Sorokoumova, G.M., Vasilenko, I.A., Yakub, I.S., and Shvets, V.I., Biol.. Membr., 1987, vol. 4, no. 10, p. 1072.
Shragin, A.S., Vasilenko, I.A., Selishcheva, A.A., and Shvets, V.I., Dokl. Akad. Nauk SSSR, 1986, vol. 287, no. 3, p. 717.
Kinoshita, T., Fujita, M., and Maeda, Y., J. Biochem., 2008, vol. 144, no. 3, p. 287.
Brown, J.R., Crawford, B.E., and Esko, J.D., Crit. Rev. Biochem. Mol. Biol., 2007, vol. 42, no. 6, p. 481.
Dekker, L.V., Protein Kinase C, New York: Springer, 2004.
Newton, A.C., J. Biol. Chem., 1995, vol. 270, no. 48, p. 28495.
Gusev, N.B., Soros. Obrazovat. Zh., 2000, vol. 6, no. 12, p. 4.
Krasnopol’skii, Yu.M. and Shvets, V.I., Ukr. Biokhim. Zh., 1984, vol. 56, no. 3, p. 253.
Krasnopol’skii, Yu.M., Gol’bets, I.I., Orlova, G.L., Sennikov, G.A., and Shvets, V.I., Khim.-Farm. Zh., 1983, no. 4, p. 401.
Sennikov, G.A., Reznikova, L.S., Gol’bets, I.I., Orlova, G.L, Krasnopol’skii, Yu.M., and Shvets, V.I., Vestn. Dermatol. Venerol., 1978, no. 7, p. 48.
Vasilenko, I.A., Chupin, V.V., Krasnopol’skii, Yu.M., Gol’bets, I.I., Sennikov, G.A., Evstigneeva, R.P., and Shvets, V.I., Khim.-Farm. Zh., 1981, no. 2, p. 14.
Krasnopol’skii, Yu.M., Gol’bets, I.I., Orlova, G.L., Sennikov, G.A., and Shvets, V.I., Vestn. Dermatol. Venerol., 1986, no. 8, p. 51.
Krasnopol’skii, Yu.M., Stepanov, A.E., and Shvets, V.I., Biofarm. Zh., 2011, vol. 3, no. 2, p. 10.
Kaplun, A.P., Le Bang Son, Krasnopol’skii, Yu.M., and Shvets, V.I., Vopr. Med. Khim., 1999, vol. 45, no. 1, p. 3.
Kaplun, A.P., Zhizn’ bez opasnosti. Zdorov’e. Profilaktika. Dolgoletie, 2007, no. 3, p. 18.
Shvets, V.I., in Sbornik materialov XIX (82) sessii Obshchego sobraniya Rossiiskoi Akademii Meditsinskikh Nauk (Proceedings of the XIX (82) Session of the General Assembly of the Russian Academy of Medical Sciences), Moscow: Meditsina, 2008, p. 159.
Shvets, V.I., Kaplun, A.P., Krasnopol’skii, Yu.M., Stepanov, A.E., and Chekhonin, V.P., Ross. Nanotekhnol., 2008, vol. 3, no. 11–12, p. 52.
Krasnopol’skii, Yu.M., Stepanov, A.E., and Shvets, V.I., Khim.-Farm. Zh., 1999, no. 10, p. 20.
Shvets, V.I., Phospholipids in biotechnologies, Vestn. MITKhT, 2009, vol. 4, no. 4, p. 4.
Ipatova, O.M., Fosfogliv—mekhanizm deistviya i primenenie v klinike (Phosphogliv—Mechanism of Action and Clinical Use), Moscow: Izd. GU NII Biomed. Khimii Ross. Akad. Med. Nauk, 2005.
Obedimskii, D.D., Stepanov, A.E., Kaplun, A.P., Krasnopol’skii, Yu.M., Dudnichenko, A.S., Pobedimskii, D.G., and Shvets, V.I., Khimiya i rynok, 2004, no. 3, p. 13.
Bureeva, S.V., Andia-Pravdivy, J.E., Petrov, G.N., Igumnov, M.A., Romanov, S.V., Kolesnikova, E.A., Kaplun, A.P., and Kozlov, L.V., J. Bioorg. Med. Chem., 2005, vol. 13, no. 4, p. 1045.
Bureeva, S., Andia-Pravdivy, J., Symon, A., Bichucher, A., Moskaleva, V., Popenko, V., Shpak, A., Shvets, V., Kozlov, L., and Kaplun, A., J. Bioorg. Med. Chem., 2007, vol. 15, no. 3, p. 3489.
Chekhonin, V.P., Gurina, O.I., Lokhonina, O.V., Ryabinina, A.E., Maksimova, M.A., Semenova, A.V., and Shvets, V.I., Dokl. Akad. Nauk, 2007, vol. 417, no. 4, p. 1.
Naroditskii, B.S., Shmarov, M.M., and Logunov, D.Yu., in Sbornik materialov XIX (82) sessii Obshchego sobraniya Rossiiskoi Akademii Meditsinskikh nauk (TRANSLATION), Moscow: Meditsina, 2008.
Leskova, G.F., Kryzhanovskii, G.N., Arkhipenko, Yu.V., Kaplun, A.P., Krasnopol’skii, Yu.M., and Shvets, V.I., RF Patent No. 2191583, 2002.
Podol’skaya, S.V., Sorokoumova, G.M., Kaplun, A.P., Lyutik, A.I., Bukhman, V.M., and Shvets, V.I., Vopr. Biol. Med. Farm. Khim., 2004, no. 3, p. 33.
Shevchenko, K.V., Khrapko, A.P., Myasoedov, N.F., and Shvets, V.I., Dokl. Akad. Nauk, 2009, vol. 429, no. 4, p. 554.
Kurilko, N.A., Kiyamov, A.K., Ivanova, M.A., Pashkov, E.P., Aleksandrov, M.T., Sorokoumova, G.M., and Shvets, V.I., Antibiot. Khimioter., 2009, vol. 54, no. 5, p. 25.
Lekarskaya, N.A., Sorokoumova, G.M., Sycheva, Yu.V., Khoroshilova-Maslova, I.P., Kaplun, A.P., Kireev, I.I., Gundorova, R.A., Neroev, V.V., and Shvets, V.I., Vestn. MITKhT, 2011, vol. 6, no. 2, p. 37.
Menzeleev, R.F., Shvets, V.I., and Tikhonov, O.I., Farm. Zh., 1992, no. 2, p. 60.
Reshetnikov, A.V., Zhigal’tsev, I.V., Kolomeichuk, S.N., Kaplun, A.P., Shvets, V.I., Zhukova, O.S., Karmenyan, A.V., Ivanov, A.V., and Ponomarev, G.V., Russ. J. Bioorg. Chem., 1999, vol. 25, no. 10, p. 782.
Rukosueva, N.V., Zakharova, D.A., Bezrukov, D.A., Kaplun, A.P., Zigangirova, N.A., Shvets, V.I., and Gintsburg, A.A., Biotekhnologiya, 2012 (in press).
Prokhorov, D.I., Zhuravko, A.S., Kaplun, A.P., Shvets, V.I., Sariev, A.K., Abaimov, D.A., Shiryaeva, M.V., Kapitsa, I.G., Voronina, T.A., and Seifulla, R.D., Vestn. MITKhT, 2012 (in press).
Mal’kovskaya, G.M., Viktorov, A.V., Vasilenko, I.A., Mironov, A.F., Shvets, V.I., Evstigneeva, R.P., Obraztsov, V.V., Tarakhovkii, Yu.S., Borovyagin, V.L., Petrov, V.I., and Sennikov, G.A., Bioorg. Khim., 1982, vol. 8, no. 11, p. 1563.
Temirov, Yu.P., Shvets, V.I., Krasnopol’skii, Yu.M., and Sennikova, I.G., UA Patent No. 69903, 2006.
Gel’perina, S.E. and Shvets, V.I., Biotekhnologiya, 2009, no. 3, p. 8.
Gregoriadis, G. and Neerunjun, E.D., Biochem. Biophys. Res. Commun., 1975, vol. 65, p. 337.
Torchilin, V.P., Khau, B.A., Smirnov, V.N., and Habor, E., Biochem. Biophys. Res. Commun., 1979, vol. 89, no. 4, p. 1114.
Kaplun, A.P., Bezrukov, D.A., and Shvets, V.I., Biotekhnologiya, 2010, no. 6, p. 9.
Kaplun, A.P., Bezrukov, D.A., Shvets, V.I., and Kubatiev, A.A., Nanotekhnol. Okhr. Zdor., 2011, no. 2, p. 9.
Kaplun, A.P., Bezrukov, D.A., Popenko, V.I., and Shvets, V.I., Biofarm. Zh., 2011, vol. 3, no. 2, p. 28.
Andreevskaya, S.N., Smirnova, T.G., Zhogina, Yu.A., Smirnova, D.I., Mikulovich, Yu.L., Sorokoumova, G.M., Chernousova, L.N., Selishcheva, A.A., and Shvets, V.I., Dokl. Akad. Nauk, 2010, vol. 434, no. 5, p. 705.
Smirnova, T.G., Mikulovich, Yu.L., Andreevskaya, S.N., Sorokoumova, G.M., Chernousova, L.N., Selishcheva, A.A., and Shvets, V.I., Biofarm. Zh., 2011, vol. 3, no. 2, p. 19.
Krasil’nikov, I.V., Gambaryan, A.S., Mashin, V.V., and Lobastova, A.K., Vopr. Virusol., 2010, no. 2, p. 24.
Khalanskii, A.S., Khekmatara, T., Bernroiter, K., Rubtsov, B.V., Kondakova, L.I., Matchke, K., Kroiter, I., Glattsel, M., Gel’perina, S.E., and Shvets, V.I., Biofarm. Zh., 2011, vol. 3, no. 2, p. 41.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © V.I. Shvets, A.A. Kubatiev, D.L. Shobolov, V.Yu. Balaban’yan, 2012, published in Obzornyi Zhurnal po Khimii, 2013, Vol. 3, No. 3, pp. 199–227.
Rights and permissions
About this article
Cite this article
Shvets, V.I., Kubatiev, A.A., Shobolov, D.L. et al. Biopharmaceutical technologies based on phospholipids (chemistry, biochemistry, biophysics, biotechnology, physiology, immunology, pharmacology, and production technologies of medicinal and diagnostic preparations, including nanosized preparations). Ref. J. Chem. 3, 179–206 (2013). https://doi.org/10.1134/S2079978013030047
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2079978013030047