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Protective Effect of Short Peptides on the Insect Nervous System

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Abstract

An urgent task in modern biology and medicine is the study of the biologically active substances that can correct functional cellular activity that has been weakened by various pathologic processes. The neuroprotective properties of short peptides are analyzed in the review with a study of the conditioned reflex in the honey-bee Apis mellifera L. EDR and AEDG peptides stimulated their short-term and long-term memory. EDR peptide also increases the locomotor activity in the fly Drosophila melanogaster in a model of Parkinson disease for a decrease in the expression level of the gene limk1, and it also recovers the short-term memory in Agnst3 mutant. The discovery of the stimulating effect of EDR and AEDG peptides on the function of the central nervous system served as the basis for the testing of drugs for the treatment of pathology of the central nervous system. The parallelism of neuroprotective effect in two animal groups, mammals and insects, indicated the existence of a common, possibly the oldest, mechanism of peptide regulation of the life activities of organisms.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    N. I. Chalisova, G. A. Ryzhak & O. M. Ivko

  2. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. I. Chalisova

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  1. N. I. Chalisova
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Correspondence to N. I. Chalisova.

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Chalisova, N.I., Ryzhak, G.A. & Ivko, O.M. Protective Effect of Short Peptides on the Insect Nervous System. Biol Bull Rev 11, 597–601 (2021). https://doi.org/10.1134/S2079086421060025

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