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The Adaptation Role of Serine/Threonine Kinase Akt1 in Anabolism of Muscular Tissue

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Abstract

The article reviews the particular qualities of the key signal component of anabolic pathways (serine/threonine kinase Akt1) in the regulation of skeletal muscle functioning, both under normal conditions and in the dystrophic process, including Duchenne’s muscular dystrophy. The current data confirm the participation of the Akt1 signal pathway in the processes of skeletal muscle regeneration, as well as in the mechanism of angiogenesis amplification, which demonstrates the great therapeutic potential of Akt1 as a target for the treatment of a wide range of hereditary and acquired neuromuscular diseases.

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ACKNOWLEDGMENTS

This study was supported by the Russian Science Foundation (grant no. 17-15-01111).

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Authors and Affiliations

  1. Center of Personalized Medicine, Sechenov First Moscow State Medical University, Moscow, Russia

    V. S. Sukhorukov

  2. Pirogov Russian National Research Medical University, Moscow, Russia

    V. S. Sukhorukov, T. I. Baranich & V. V. Glinkina

  3. Russian-Speaking Academic Science Association (RASA) Center, National Research Tomsk Polytechnic University, Tomsk, Russia

    D. N. Atochin

  4. Cardiovascular Research Center, Cardiology Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States

    D. N. Atochin

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  1. V. S. Sukhorukov
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  2. T. I. Baranich
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Correspondence to V. S. Sukhorukov, T. I. Baranich, D. N. Atochin or V. V. Glinkina.

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Sukhorukov, V.S., Baranich, T.I., Atochin, D.N. et al. The Adaptation Role of Serine/Threonine Kinase Akt1 in Anabolism of Muscular Tissue. Biol Bull Rev 8, 489–496 (2018). https://doi.org/10.1134/S2079086418060105

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