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Biology Bulletin Reviews

, Volume 8, Issue 2, pp 142–154 | Cite as

Regulation of Telomerase Activity

  • D. S. Nalobin
  • A. A. Galiakberova
  • S. I. Alipkina
  • A. I. Glukhov
Article
  • 15 Downloads

Abstract

The published data on the regulation of telomerase activity are systemized. The structure and functions of telomeres and telomerase are described. The main pathways of epigenetic regulation of telomerase activity—modification of the TERT (telomerase reserve transcriptase) gene histone and its methylation— are described. Particular attention is paid to the regulation of telomerase activity at the transcriptional level (transcriptional activators and inhibitors of TERT, as well as two-way transcription regulators) and posttranscriptional regulation (alternative splicing of TERT mRNA, phosphorylation, and ubiquitination of TERT).

Keywords

telomere telomerase activity regulation telomerase functions telomerase complex genes 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • D. S. Nalobin
    • 1
  • A. A. Galiakberova
    • 1
  • S. I. Alipkina
    • 1
  • A. I. Glukhov
    • 1
    • 2
  1. 1.Moscow State UniversityMoscowRussia
  2. 2.Sechenov First Moscow State Medical UniversityMoscowRussia

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