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Pathology of synapses in neurological diseases

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Abstract

The dysfunction and degeneration of synapses in neurological diseases have been widely discussed recently. The early clinical symptoms of these diseases are accompanied by a loss or dysfunction of synapses. These results allow us to propose the existence of common molecular and cellular mechanisms for neurological diseases that are directly linked to these processes. The article contains a detailed description of synaptic disorders in Alzheimer’s disease, Parkinson’s disease, prion diseases, Huntington’s disease, autism, and amyotrophic lateral sclerosis. The role of synaptic dysfunctions in aging is also discussed.

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  1. Petersburg Nuclear Physics Institute, National Research Center “Kurchatov Institute,”, Russian Academy of Sciences, Orlova Roscha, Gatchina, Leningrad oblast, 188300, Russia

    A. L. Schwarzman & S. V. Sarantseva

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Original Russian Text © A.L. Schwarzman, S.V. Sarantseva, 2014, published in Uspekhi Sovremennoi Biologii, 2014, Vol. 134, No. 4, pp. 395–408.

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Schwarzman, A.L., Sarantseva, S.V. Pathology of synapses in neurological diseases. Biol Bull Rev 4, 515–526 (2014). https://doi.org/10.1134/S2079086415020085

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