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Longevity control in fungi and other organisms: The conception of scales

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Abstract

This review deals mainly with gerontological processes that occur on the cellular-colonial level of organization in fungi and cellular-tissular level in other organisms. Aging and antiaging mechanisms operating on these levels of organization can be considered as common for all living things. Fungi, with their tissular-like organization of the thallus, afford a broad spectrum of possibilities for solving the tasks of general gerontological import. Three basic (chronological, replicative, and cell-suicidal) and several auxiliary mechanisms of aging are distinguished, and the classification of stochastic aging factors accumulating in cells is given. It is shown that, in complex multicellular organisms, aging and antiaging mechanisms operate on the level of interactions between tissues, though the aforesaid conservative basic mechanisms underlie their actions. A preliminary generalized conception of aging—the conception of scales—is put forward, founded on the model of balanced and nonbalanced counteractions between stressful impacts and various mechanisms of aging and antiaging with a different extent of genetic preprogramming. The important contribution of mycological gerontology to broadening inferences on the nature of aging is reaffirmed.

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  1. Department of Mycology and Algology, Biological Faculty, Moscow State University, Moscow, 119991, Russia

    I. S. Mazheika, O. A. Kudryavtseva & O. V. Kamzolkina

  2. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    I. S. Mazheika

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Original Russian Text © I.S. Mazheika, O.A. Kudryavtseva, O.V. Kamzolkina, 2011, published in Zhurnal Obshchei Biologii, 2011, Vol. 72, No. 4, pp. 243–268.

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Mazheika, I.S., Kudryavtseva, O.A. & Kamzolkina, O.V. Longevity control in fungi and other organisms: The conception of scales. Biol Bull Rev 2, 55–75 (2012). https://doi.org/10.1134/S2079086412010045

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