Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation

  • M. A. TikhonovaEmail author
  • T. G. Amstislavskaya


Sexual behavior is one of the biologically highly relevant types of behavior. Sexual arousal, or the initial stage of sexual behavior, is of particular interest since it triggers all the following events, but still remains the least known element of this behavior. Sexual dysfunctions are caused by aging, stress, or the side effects of psychotropic drugs; they are symptoms of a variety of neurological and psychiatric disorders. Therefore, the study of sexual behavior appears to be an important step in modeling various animal pathologies and the effects of psychotropic drugs. We have phenotyped animals with a hereditary predisposition to catalepsy using our previous development, a model of male sexual arousal, and examined the relationship between catalepsy and sexual arousal. The major gene for a high predisposition to catalepsy was shown to be associated with the expression of sexual motivation, but not with the hormonal component of sexual arousal (increase in the plasma testosterone levels following exposure to a receptive female). ASC (Antidepressant Sensitive Catalepsy) mice, proposed as a model of depression, had a decreased manifestation of sexual motivation, while male GC (Genetic Catalepsy) strain rats had enhanced sexual motivation. We note that the highly excitable GC strain animals corresponding to the manic pole of bipolar disorders prevail at the current stage of breeding. Our results are in good agreement with the clinical data that indicate reduced libido in depressed patients and hypersexuality in people with bipolar disorder.


male sexual behavior mouse rat sexual activation sexual motivation testosterone catalepsy selective models of psychopathology affective disorders 


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  1. Adelson, S., Psychodynamics of hypersexuality in children and adolescents with bipolar disorder, J. Am. Acad. Psychoanal. Dyn. Psychiatry, 2010, vol. 38, pp. 27–45.CrossRefPubMedGoogle Scholar
  2. Alekhina, T.A., Petrova, G.V., Barykina, N.N., Prokudina, O.I., Chugui, V.F., Sakharov, D.G., and Kolpakov, V.G., Changes in the neuro-endocrine system of rats of the cataleptic strain. Influence of ontogenesis and the number of breeding generations, Ross. Fiziol. Zh. im. I. M. Sechenova, 2006, vol. 92, no. 4, pp. 499–505.PubMedGoogle Scholar
  3. Amstislavskaya, T.G. and Khrapova, M.V., Influence of genotype on behavioral and hormonal components of sexual arousal in male mice, Byul. Eksp. Biol. Med., 2002, vol. 133, pp. 548–551.CrossRefGoogle Scholar
  4. Amstislavskaya, T.G. and Osipov, K.V., Sexual arousal in male rats: Behavior and hormonal response, Byul. SO RAMN, 2003, vol. 3, pp. 112–114.Google Scholar
  5. Amstislavskaya, T.G. and Popova, N.K., Female-induced sexual arousal in male mice and rats: Behavioral and testosterone response, Horm. Behav., 2004, vol. 46, no. 5, pp. 544–550.CrossRefPubMedGoogle Scholar
  6. Amstislavskaya, T.G., Gladkikh, D.V., Belousova, I.I., Maslova, L.N., and Kolosova, N.G., Age-related aspects of the sexual behavior of male rats with different rates of aging, Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova, 2010, vol. 60, no. 5, pp. 552–559.Google Scholar
  7. Amstislavskaya, T.G., Maslova, L.N., Gladkikh, D.V., Belousova, I.I., Stefanova, N.A., and Kolosova, N.G., Effects of the mitochondria-targeted antioxidant SkQ1 on sexually motivated behavior in male rats, Pharmacol. Biochem. Behav., 2010, vol. 96, no. 2, pp. 211–216.CrossRefPubMedGoogle Scholar
  8. Baldwin, D.S., Sexual dysfunction associated with antidepressant drugs, Expert. Opin. Drug Saf., 2004, vol. 3, no. 5, pp. 457–470.CrossRefPubMedGoogle Scholar
  9. Bazovkina, D.V., Kulikov, A.V., Kondaurova, E.M., and Popova, N.K., Selection for the predisposition to catalepsy enhances depressive-like traits in mice, Russ. J. Genet., 2005, vol. 41, no. 9, pp. 1002–1007.CrossRefGoogle Scholar
  10. Belousova, I.I., Gladkikh, D.V., Zhelezova, A.I., Stefanova, N.A., Kolosova, N.G., and Amstislavskaya, T.G., Age-related aspects of the reproductive function of male rats with a conventional and an accelerated pace of aging, Ross. Fiziol. Zh. im. I. M. Sechenova, 2009, vol. 95, no. 11, pp. 1258–1267.PubMedGoogle Scholar
  11. Clayton, A.H. and Montejo, A.L., Major depressive disorder, antidepressants, and sexual dysfunction, Clin. Psychiatry, 2006, vol. 67, pp. 33–37.Google Scholar
  12. Ferreira-Nuno, A., Overstreet, D.H., Morales-Otal, A., and Velazquez-Moctezuma, J., Masculine sexual behavior features in the Flinders sensitive and resistant line rats, Behav. Brain. Res., 2002, vol. 128, pp. 113–119.CrossRefPubMedGoogle Scholar
  13. Gronli, J., Murison, R., Fiske, E., Bjorvatn, B., Sorensen, E., Portas, C.M., and Ursin, R., Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions, Physiol. Behav., 2005, vol. 84, no. 4, pp. 571–577.CrossRefPubMedGoogle Scholar
  14. Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M.T., Sheridan, J.F., and Godbout, P.J., Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia, J. Neuroinflam., 2008, vol. 5, no. 15, pp. 1–14.Google Scholar
  15. Kolpakov, V.G., Kulikov, A.V., Alekhina, T.A., Chuguy, V.F., Petrenko, O.I., and Barykina, N.N., Catatonia or depression: The Gcrat strain as an animal model of psychopathology, Russ. J. Genet., 2004, vol. 40, no. 6, pp. 672–678.CrossRefGoogle Scholar
  16. Kulikov, A.V., Kolpakov, V.G., and Popova, N.K., The genetic cataleptic (GC) rat strain as a model of depressive disorders, in Animal Models in Biological Psychiatry, Kaluev, A., Ed., New York: Nova Sci. Publ. Inc., 2006.Google Scholar
  17. Kulikov, A.V., Bazovkina, D.V., Kondaurova, E.M., and Popova, N.K., Genetic structure of hereditary catalepsy in mice, Genes Brain Behav., 2008, vol. 7, no. 4, pp. 506–512.CrossRefPubMedGoogle Scholar
  18. Pfaus, J.G., Revisiting the concept of sexual motivation, Annu. Rev. Sex Res., 1999, vol. 10, pp. 120–156.PubMedGoogle Scholar
  19. Roney, J.R., Lukaszewski, A.W., and Simmons, Z.L., Rapid endocrine responses of young men to social interactions with young women, Horm. Behav., 2007, vol. 52, no. 3, pp. 326–333.CrossRefPubMedGoogle Scholar
  20. Rosing, D., Klebingat, K.J., Berberich, H.J., Bosinski, H.A., Loewit, K., and Beier, K.M., Male sexual dysfunction: Diagnosis and treatment from a sexological and interdisciplinary perspective, Dtsch. Arztebl. Int., 2009, vol. 106, pp. 821–828.PubMedPubMedCentralGoogle Scholar
  21. Ryazanova, M.A., Igonina, T.N., Alekhina, T.A., and Prokudina, O.I., The increase in the proportion of nervous animals bred for catatonia: The participation of central adrenoreceptors in catatonic reactions, Russ. J. Genet., 2012, vol. 48, no. 11, pp. 1141–1147.CrossRefGoogle Scholar
  22. Sanberg, P.R., Bunsey, M.D., Giordano, M., and Norman, A.B., The catalepsy test: Its ups and downs, Behav. Neurosci., 1988, vol. 102, pp. 748–759.CrossRefPubMedGoogle Scholar
  23. Tikhonova, M.A., Otroshchenko, E.A., and Kulikov, A.V., Influence of chronic administration of fluoxetine on the severity of sexual motivation and social behavior of ASC mice, Ross. Fiziol. Zh. im. I. M. Sechenova, 2010, vol. 96, no. 2, pp. 163–172.PubMedGoogle Scholar
  24. Tikhonova, M.A., Yu, C.H., Kolosova, N.G., Gerlinskaya, L.A., Maslennikova, S.O., Yudina, A.V., Amstislavskaya, T.G., and Ho, Y.J., Comparison of behavioral and biochemical deficits in rats with hereditary defined or D-galactoseinduced accelerated senescence: Evaluating the protective effects of diosgenin, Pharmacol. Biochem. Behav., 2014, vol. 120, pp. 7–16.CrossRefPubMedGoogle Scholar
  25. Wang, D., Noda, Y., Tsunekawa, H., Zhou, Y., Miyazaki, M., Senzaki, K., and Nabeshima, T., Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety, Behav. Brain Res., 2007, vol. 178, pp. 262–273.CrossRefPubMedGoogle Scholar

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© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Scientific Research Institute of Physiology and Basic MedicineNovosibirskRussia
  2. 2.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia

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