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Vascular Aging and Telomere Biology: On the Role of Vitamin D3 Deficiency

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Abstract

The impact of vitamin D3 deficiency on the risk and prognosis of numerous chronic diseases has been actively studied for years. Recent research demonstrates that vitamin D is not merely involved in controlling calcium– phosphorus metabolism, but can also enhance insulin sensitivity, and decrease the incidence of type-2 diabetes mellitus (T2DM), obesity, and the autoimmune destruction of pancreatic β cells. The influence of vitamin D3 on some cardiometabolic risk factors and cardiovascular disease (CVD) is described. Thus, it seems quite relevant to study the role of vitamin D3 in the development of arterial-wall changes in the case of T2DM and insulin resistance (IR) and their relationship with the biology of telomeres. The study is aimed at investigating the relationship between vitamin D3 deficiency and vascular-wall condition by the telomere biology in patients with varying insulin sensitivity. The cross-sectional study involves 305 patients (106 men and 199 women) aged 51.5 ± 13.3 SU. All patients undergo laboratory and instrumental tests; the morphofunctional state of the vascular wall is studied. The telomere length and telomerase activity are determined using polymerase chain reaction. Altogether 18 out of 248 patients (7.2%) are found to have normal vitamin D3 levels (above 30 ng/mL). Vitamin D3 insufficiency or deficiency is determined in 92.8% of subjects. The increase in the vitamin D3 deficiency is accompanied by an increased level of fasting glucose, HbA1c and its elevated concentration, HOMA index, glucose disorders up to T2DM, and higher vascular stiffness. Telomerase activity in the group with vitamin D3 deficiency is significantly lower than in the groups with vitamin D3 insufficiency and normal concentrations. Multiple linear regression analysis shows that they are independently associated with vitamin D3 in T2DM (B = 1.43; st. OR 0.106; p = 0.0001), vascular stiffness (B = 0.075; st. OR 2.11; p = 0.017), fasting glucose (B = 0.169; st. OR 1.62; p = 0.004), HbA1c level (B = 0.062; st. OR 7.4; p = 0.001) and the presence of “short” telomeres (B = 0.09; st. OR 1.154; p = 0.001). Receiver-operating characteristic (ROC) analysis reveals relationships between the BMI (0.634, p = 0.001), duration of T2DM (0.651, p = 0.022), high intima-media thickness (0.614, p = 0.004), vascular stiffness (0.605, p < 0.001), HbA1c (0.588, p = 0.022), and the presence of vitamin D3 deficiency. In persons with varying insulin sensitivity, from insulin resistance to T2DM, it is advisable to assess the vitamin D3 levels for effective prevention of arterial-wall changes in addition to traditional CVD risk factors. Vitamin D3 deficiency requires the active prevention of metabolic disorders and vascular changes.

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ACKNOWLEDGMENTS

We are grateful to A.S. Kruglikova, E.V. Plokhova, V.S. Pykhtina, N.V. Gomyranova, V.A. Vygodin, Federal State Budgetary Institution “National Medical Research Center for Therapy and Preventive Medicine” of the Ministry of Health of the Russian Federation, and D.A. Skvortsov, Belozersky Institute of Physico-Chemical Biology (one of the key research and educational subdivisions of Moscow State University) for their assistance in the study.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Aging Diseases, Faculty of Additional Professional Education, Pirogov Russian National Research Medical University, Moscow, Russia

    E. N. Dudinskaya, O. N. Tkacheva, I. D. Strazhesko & N. V. Sharashkina

  2. Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University, Moscow, Russia

    E. N. Dudinskaya, O. N. Tkacheva, I. D. Strazhesko, N. V. Brailova & N. V. Sharashkina

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  1. E. N. Dudinskaya
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Correspondence to E. N. Dudinskaya.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Translated by E. Makeeva

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Dudinskaya, E.N., Tkacheva, O.N., Strazhesko, I.D. et al. Vascular Aging and Telomere Biology: On the Role of Vitamin D3 Deficiency. Adv Gerontol 13, 156–163 (2023). https://doi.org/10.1134/S2079057024600368

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