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Brain Aging

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Abstract

Brain aging is part of the aging of the whole body, largely determining the success of general aging and the quality of life of an older person. Brain aging is a complex multifactorial process that occurs throughout a human’s life, which includes changes at subcellular, tissue, and organ levels as well as at physiological level, mediating changes in neurophysiological (cognitive) functions. The review provides up-to-date data on morphological and physiological changes observed during natural aging; it discusses various phenotypes of brain aging, including both pathologically accelerated and “supernormal” aging; questions of the division between the norm and pathology are raised in the context of changes observed during brain aging; the factors both accelerating and decelerating the aging processes of the brain are considered along with linkage of natural aging with neurodegenerative and cerebrovascular diseases.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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  1. Russian Gerontology Research and Clinical Center, Pirogov National Research Medical University, Moscow, Russia

    M. A. Cherdak

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Translated by L. Solovyova

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Cherdak, M.A. Brain Aging. Adv Gerontol 13, 70–77 (2023). https://doi.org/10.1134/S2079057024600198

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