This article examines the phenomenon of “intrauterine programming,” which largely determines the further life cycle and the likelihood of developing a number of age-associated pathological processes. The possibility of the formation of pathological (accelerated) aging at various stages of ontogenesis is discussed with the use of a large amount of published material from the standpoint of modern science. The reasons, mechanisms and phenotypic manifestations of accelerated aging and the possibilities of the earliest, its diagnosis starting from the perinatal period, and prediction of age-associated pathologies are discussed in close interrelation.
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Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (v 2-kh t.) (Molecular and Physiological Mechanisms of Aging (2 vols.)), St. Petersburg: Nauka, 2008.
Clinical Trials Database: Trial no. NCT03430037 of February 6, 2018, topic: “Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women (AFFIRM)” (April 14, 2021) [electronic resource], ClinicalTrials.gov. URL: https://clinicaltrials.gov/ct2/home.
Gavrilov, I.V., Meshchaninov, V.N., Shcherbakov, D.L., et al., Screening of functional, biochemical and cell-hematological parameters of the body as markers of human aging, Vestn. Ural’skoi Med. Akad. Nauki, 2018, vol. 15, no. 5, pp. 691–703.
Gavrilov, I.V., Meshchaninov, V.N., Shcherbakov, D.L., et al., Aging of the body and age-related dynamics of biomarkers of human gerodiagnostics, Vestn. Ural’skoi Med. Akad. Nauki, 2020, vol. 17, no. 4, pp. 272–284.
Gavrilov, L.A. and Gavrilova, N.S., Is aging a disease? Viewpoint of biodemographers, Usp. Gerontol., 2017, vol. 30, no. 6, pp. 841–842.
Golubev, A.G., Is aging a disease? Viewpoint of a biogerontologist: Old age ≠ illness, Adv. Gerontol., 2017, vol. 30, no. 6, pp. 845–847.
Dil’man, V.M., Bol’shie biologicheskie chasy. Vvedenie v integral’nuyu meditsinu (Big Biological Clock. Introduction into Integral Medicine), Moscow: Znanie, 1986.
Trial “SRK-015 for Spinal Muscular Atrophy (SMA).” Scholar Rock Biopharmaceutical Company (April 15, 2021) [electronic resource], URL: https://scholarrock.com.
Kovtun, O.P. and Tsyv’yan, P.B., Epigenetic mechanisms of fetal programming of diseases in children and adults, Ros. Vestn. Perinatol. Pediatr., 2009, vol. 54, no. 2, pp. 72–76.
Meshchaninov, V.N., Tkachenko, E.L., Zharkov, S.V., et al., Effects of synthetic peptides on aging tempos in patients with chronic polimorbid and psychoorganic disorders of the central nervous system at the stage of remission, Usp. Gerontol., 2015, vol. 28, no. 1, pp. 62–67.
Meshchaninov, V.N., Shcherbakov, D.L., and Lukash, V.A., Metabolizm kletochnykh struktur pri starenii i stresse (Metabolism of Cellular Structures in Aging and Stress), Yekaterinburg, 2017.
Moskalev, A.A., Is aging a disease? Viewpoint of a geneticist, Usp. Gerontol., 2017, vol. 30, no. 6, pp. 843–844.
Myakotnykh, V.S., Is aging a disease? Viewpoint of a geriatrist, Usp. Gerontol., 2017, vol. 30, no. 6, pp. 848–850.
Myakotnykh, V.S., Torgashov, M.N., Egorin, K.V., et al., Comparative analysis of different methods of geroprotection, Usp. Gerontol., 2016, vol. 29, no. 4, pp. 594–601.
Novikova, D.S., Garabadzhiu, A.V., Melino, G., et al., AMPK: structure, function and involvement in pathological processes, Biokhimiya, 2015, vol. 80, no. 2, pp. 163–183.
Novoselov, V.M., Is aging a disease? Usp. Gerontol., 2017, vol. 30, no. 6, pp. 836–840.
Rubinskii, A.V., Lin’kova, N.S., Chalisova, N.I., et al., Epigenetic regulation in pathology and aging, Usp. Gerontol., 2021, vol. 34, no. 1, pp. 10–17.
Khavinson, V.Kh., Therapeutic peptides: past, present, future, Klin. Med., 2020, vol. 98, no. 3, pp. 165–177.
Aguilera, A. and García-Muse, T., Causes of genome instability, Annu. Rev. Genet., 2013, vol. 4, pp. 1–32.
Aiken, C.E. and Ozanne, S.E., Transgenerational developmental programming, Hum. Reprod. Update, 2014, vol. 20, no. 1, pp. 63–75.
Armanios, M. and Blackburn, E.H., The telomere syndromes, Nat. Rev. Genet., 2012, vol. 13, no. 10, pp. 693–704.
Assadiasl, S., Mooney, N., Mohebbi, B., et al., Sirtuin 1: a dilemma in transplantation, J. Transplantat., 2020, vol. 2020, pp. 1–11. https://doi.org/10.1155/2020/9012980
Assefa, B.T., Tafere, G.G., Wondafrash, D.Z., and Gidey, M.T., The bewildering effect of AMPK activators in Alzheimer’s disease: Review of the current evidence, Biomed. Res. Int., 2020, vol. 2020, аrticle ID 9895121. https://doi.org/10.1155/2020/9895121
Barker, D.J. and Osmond, C., Childhood respiratory infection and adult chronic bronchitis in England and Wales, Brit. Med. J. (Clin. Res. Ed.), 1986, vol. 293, pp. 1271–1275.
Barzilai, N., Crandall, J.P., Kritchevsky, S.B., and Espeland, M.A., Metformin as a tool to target aging, Cell Metab., 2016, vol. 23, no. 6, pp. 1060–1065.
Blagosklonny, M.V., Aging is not programmed: genetic pseudo-program is a shadow of developmental growth, Cell Cycle, 2013, vol. 24, no. 12, pp. 3736–3742.
Blasco, M.A., Bobadilla, M., Flores, J.M., et al., Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres, eLife, 2018, vol. 7. e31299. https://doi.org/10.7554/eLife.31299
Bogan, K.L. and Brenner, C., Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition, Ann. Rev. Nutr., 2008, vol. 28, pp. 115–130.
Bosch-Presegué, L. and Vaquero, A., The dual role of sirtuins in cancer, Genes. Cancer, 2011, no. 6, pp. 648–662.
Carafa, V., Nebbioso, A., and Altucci, L., Sirtuins and disease: the road ahead, Front. Pharmacol., 2012, no. 3, pp. 4–10.
Carafa, V., Rotili, D., Forgione, M., et al., Sirtuin functions and modulation: from chemistry to the clinic, Clin. Epigenet., 2016, vol. 61, no. 8, pp. 2–21.
Chahal, J., Gómez-Aristizábal, A., Shestopaloff, K., et al., Bone marrow mesenchymal stromal cells in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation, Stem. Cells Transl. Med., 2019, vol. 8, no. 8, pp. 746–757.
Chen, Y., Hong, T., Wang, S., et al., Epigenetic modification of nucleic acids: from basic studies to medical applications, Chem. Soc. Rev., 2017, vol. 46, no. 10, pp. 2844–2872.
Chen, Y., Zhang, J., Lin, Y., et al., Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS, EMBO Rep., 2011, vol. 12, no. 6, pp. 534–541.
Chesnokova, A.Y., Ekimova, I.V., and Pastukhov, Y.F., Parkinson’s disease and aging, Adv. Gerontol., 2018, vol. 31, no. 5, pp. 668–678.
Chiti, F. and Dobson, C.M., Protein misfolding, amyloid formation and human disease: a summary of progress over the last decade, Annu. Rev. Biochem., 2017, vol. 86, pp. 27–68.
Coppé, J.P., Desprez, P.Y., Krtolica, A., and Campisi, J., The senescence-associated secretory phenotype: the dark side of tumor suppression, Ann. Rev. Pathol., 2010, no. 5, pp. 99–118.
Corbett, N. and Alda, M., On telomeres long and short, J. Psychiatry Neurosci., 2015, vol. 40, no. 1, pp. 3–4.
Corbi, G., Conti, V., Scapagnini, G., et al., Role of sirtuins, calorie restriction and physical activity in aging, Front. Biosci. (Elite Ed.), 2012, no. 4, pp. 768–778.
Currais, A., Farrokhi, C., Dargusch, R., et al., Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse, J. Geront. A. Biol. Sci. Med. Sci., 2018, vol. 73, no. 3, pp. 299–307.
Dubal, D.B., Yokoyama, J.S., Zhu, L., et al., Life extension factor Klotho enhances cognition, Cell Rep., 2014, vol. 7, no. 4, pp. 1065–1076.
Dubal, D.B., Zhu, L., Sanchez, P.E., et al., Life extension factor Klotho prevents mortality and enhances cognition in HAPP transgenic mice, J. Neurosci., 2015, vol. 35, no. 6, pp. 2358–2371.
Fisher, R.A., Krishnan, R., Tsubery, H., et al., A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies, J. Mol. Biol., 2014, vol. 426, no. 13, pp. 2500–2519.
Fontana, L., Partridge, L., and Longo, V.D., Extending healthy life span from yeast to humans, Science, 2010, vol. 5976, pp. 321–326.
Franceschi, C., Garagnani, P., Vitale, G., et al., Inflammaging and ‘garb-aging,’ Trends Endocr. Metab., 2017, no. 3, pp. 199–212.
Francheachi, C., Garagnani, P., Morsiani, C., et al., The continuum of aging and age-related diseases: common mechanisms but different rates, Front. Med., 2018, no. 6, pp. 21–23.
Freund, A., Orjalo, A.V., Desprez, P.Y., and Campisi, J., Inflammatory networks during cellular senescence: causes and consequences, Trends Mol. Med., 2010, vol. 16, no. 5, pp. 238–246.
Fulop, T., Witkowski, J.M., Olivieri, F., and Larbi, A., The integration of inflammaging in age-related diseases, Seminars Immunol., 2018, vol. 40, pp. 17–35.
Gal, H., Porat, Z., and Krizhanovsky, V., A multiparametric assay to evaluate senescent cells, Methods Mol. Biol., 2019, vol. 1896, pp. 107–117. https://doi.org/10.1007/978-1-4939-8931-7_11
Giardini, M.A., Segatto, M., da Silva, M.S., et al., Telomere and telomerase biology, Prog. Mol. Biol. Transl. Sci., 2014, vol. 125, pp. 1–40.
Goldberg, J., Currais, A., Prior, M., et al., The mitochondrial ATP-synthase is a shared drug target for aging and dementia, Aging Cell, 2018, vol. 17, no. 2, pp. 1–13.
Golpanian, S., DiFede, D.L., Khan, A., et al., Allogeneic human mesenchymal stem cell infusions for aging frailty, J. Gerontol. Biol. Sci., 2017, vol. 72, no. 11, pp. 1505–1512.
González, A., Hall, M.N., Lin, S.C., and Hardie, D.G., AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control, Cell Metab., 2020, vol. 31, no. 3, pp. 472–492.
Gonzalez-Rodriguez, P.J., Tong, W., Xue, Q., et al., Fetal hypoxia results in programming of aberrant angiotensin II receptor expression patterns and kidney development, Int. J. Med. Sci., 2013, vol. 10, no. 5, pp. 532–538.
Greer, E.L., Oskoui, P.R., Banko, M.R., et al., The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor, J. Biol. Chem., 2007, vol. 282, no. 41, pp. 30107–30119.
Harley, C.B., Futcher, A.B., and Greider, C.W., Telomeres shorten during ageing of human fibroblasts, Nature, 1990, vol. 345, no. 6274, pp. 458–460.
Hawkins, P.T. and Stephens, L.R., PI3K signalling in inflammation, Biochim. Biophys. Acta, 2015, vol. 1851, no. 6, pp. 882–897.
Hayflick, L. and Moorhead, P.S., The serial cultivation of human diploid cell strains, Exp. Cell Res., 1961, vol. 25, no. 3, pp. 585–621.
Hekimi, S., Lapointe, J., and Wen, Y., Taking a “good” look at free radicals in the aging process, Trends Cell Biol., 2011, vol. 21, no. 10, pp. 569–576.
Higashi, Y., Sukhanov, S., Anwar, A., et al., IGF-1, oxidative stress and atheroprotection, Trends Endocr. Metab., 2010, no. 21, pp. 245–254.
Hogg, K., Blair, J.D., McFadden, D.E., et al., Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta, PLoS One, 2013, vol. 8, no. 5. e62969. https://doi.org/10.1371/journal.pone.0062969
Jackson, M.P. and Hewitt, E.W., Cellular proteostasis: degradation of misfolded proteins by lysosomes, Essays Biochem., 2016, vol. 60, no. 2, pp. 173–180.
Jiang, H., Ju, Z., and Rudolph, K.L., Telomere shortening and ageing, J. Gerontol. Geriatr., 2007, vol. 40, no. 5, pp. 314–324.
Jones, R.G., Plas, D.R., Kubek, S., et al., AMP-activated protein kinase induces a p53-dependent metabolic checkpoint, Mol. Cell, 2005, vol. 18, no. 3, pp. 283–293.
Justice, J.N., Ferrucci, L., Newman, A.B., et al., A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the Tame Biomarkers Workgroup, Geroscience, 2018, vol. 40, nos. 5–6, pp. 419–436.
Kelly, G., A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1, Altern. Med. Rev., 2010, vol. 15, no. 3, pp. 245–263.
Kim, J. and Miller, S., Geriatric syndromes: meeting a growing challenge, Nurs. Clin. North Amer., 2017, vol. 52, no. 3.
Kirkland, J.L., Navarro, D.C., Sano, T., et al., The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs, Aging Cell, 2015, vol. 14, no. 4, pp. 644–658.
Krishnan, R., Lulu, M., Rockwell-Postel, C., et al., Stability and inter-domain interactions modulate amyloid binding activity of a general amyloid interaction motif, J. Mol. Biol., 2019, vol. 431, no. 10, pp. 1920–1939.
Krukiewicz, K., Kowalik, A., Turczyn, R., and Biggs, M.J.P., In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations, Bioelectrochemistry, 2020, vol. 134, p. 107528.
Kundakovic, M. and Jaric, I., The epigenetic link between prenatal adverse environments and neurodevelopmental disorders, Genes (Basel), 2017, vol. 8, no. 3, p. 104.
Lee, J.S., Cellular senescence, aging, and age-related disease: special issue of BMB Reports in 2019, BMB Rep., 2019, vol. 52, no. 1, pp. 1–2.
Leo, L., Marchetti, M., Giunta, S., and Fanti, L., Epigenetics as an evolutionary tool for centromere flexibility, Genes, 2020, vol. 11, no. 7, p. 809.
Liang, J., Shao, S.H., Xu, Z.X., et al., The energy sensing LKB1-AMPK pathway regulates p27 (Kip1) phosphorylation mediating the decision to enter autophagy or apoptosis, Nat. Cell. Biol., 2007, vol. 9, no. 2, pp. 218–224.
Lin, J., Handschin, C., and Spiegelman, B.M., Metabolic control through the PGC-1 family of transcription coactivators, Cell. Metab., 2005, no. 6, pp. 361–370.
Lin, X., Meaney, M.J., Godfrey, K.M., et al., Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome, BMC Med., 2017, vol. 15, no. 1, pp. 1–18.
Liu, A., Guo, E., Yang, J., et al., Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy, Aging Cell, 2018, vol. 17, no. 1, pp. 1–13.
Liu, J., Wang, L., Wang, Z., and Liu, J.P., Roles of telomere biology in cell senescence, replicative and chronological ageing, Cells, 2019, vol. 8, no. 1, p. 54.
Long, K.K., O’Shea, K.M., Khairallah, R.J., et al., Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy, Hum. Mol. Genet., 2019, vol. 28, no. 7, pp. 1076–1089.
López-Otín, C., Blasco, M.A., Partridge, L., et al., The hallmarks of aging, Cell, 2013, vol. 153, no. 6, pp. 1194–1217.
Macedo, J.C., Vaz, S., and Logarinho, E., Mitotic dysfunction associated with aging hallmarks, Adv. Exp. Med. Biol., 2017, vol. 1002, pp. 153–188.
Mailloux, R.J., An update on mitochondrial reactive oxygen species production, Antioxidants, 2020, vol. 9, no. 6, p. 472.
Mannick, J., TORC1 inhibition as a potential immunotherapy to reduce infections in the elderly, Innov. Aging, 2018, no. S1, pp. 545–550.
Márquez Loza, A., Elias, V., Wong, C.P., et al., Effects of ibuprofen on cognition and NMDA receptor subunit expression across aging, Neuroscience, 2017, vol. 344, pp. 276–292.
Mavrogonatou, E., Pratsinis, H., Papadopoulou, A., et al., Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis, Matrix Biol., 2019, vols. 75–76, pp. 27–42.
Miller, J.D., Schafer, M.J., Tchkonia, T., et al., Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice, Aging Cell, 2016, vol. 15, no. 5, pp. 973–977.
Milman, S., Huffman, D.M., and Barzilai, N., The somatotropic axis in human aging: framework for the current state of knowledge and future research, Cell. Metab., 2016, vol. 23, no. 6, pp. 980–989.
Morgunova, G.V. and Klebanov, A.A., Age-related AMP-activated protein kinase alterations: from cellular energetics to longevity, Cell. Biochem. Funct., 2019, vol. 37, no. 3, pp. 169–176.
Mostoslavsky, R., Chua, K.F., Lombard, D.B., et al., Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 2006, vol. 124, no. 2, pp. 315–329.
Nambiar, A., Justice, J.N., Pascual, R.M., et al., Targeting pro-inflammatory cells in idiopathic pulmonary fibrosis: an open-label pilot study of dasatinib and quercetin, Chest, 2018, vol. 154, no. 4, рр. 395A–396A.
Nikolich-Žugich, J., The twilight of immunity: emerging concepts in aging of the immune system, Nat. Immunol., 2018, vol. 19, no. 1, pp. 10–19.
Ocampo, A., Reddy, P., Martinez-Redondo, P., and Platero-Luengo, A., In vivo amelioration of age-associated hallmarks by partial reprogramming, Cell, 2016, vol. 167, no. 7, pp. 1719–1733.
O’Connor, M.S., Boominathan, A., Vanhoozer, S., and Basisty, N., Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA complex V null mutant, Nucleic Acids Res., 2016, vol. 44, no. 19, pp. 9342–9357.
Olovnikov, A.M., Telomeres, telomerase, and aging: origin of the theory, Exp. Gerontol., 1996, vol. 31, pp. 443–448.
Osafune, K., Yamanaka, S., Yashiro, Y., et al., Induced pluripotent stem cells and their use in human models of disease and development, Physiol. Rev., 2019, vol. 99, no. 1, pp. 79–114.
Palacios, J.A., Herranz, D., De Bonis, M.L., et al., SIRT1 contributes to telomere maintenance and augments global homologous recombination, J. Cell Biol., 2010, vol. 191, no. 7, pp. 1299–1313.
Parabiosis: Reverse aging with young blood? Podcast with Irina and Michal Conboy, on January 20, 2017. URL: https://blog.humanos.me/can-we-reverse-aging-with-young-blood.
Park, S., Mori, R., and Shimokawa, I., Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction, Mol. Cells, 2013, vol. 35, no. 6, pp. 474–480.
Patterson, A.J. and Zhang, L., Hypoxia and fetal heart development, Curr. Mol. Med., 2010, vol. 10, no. 7, pp. 653–666.
Pirruccello-Straub, M., Jackson, J., Wawersik, S., et al., Blocking extracellular activation of myostatin as a strategy for treating muscle wasting, Sci. Rep., 2018, vol. 8, no. 1, p. 2292.
Prior, M., Dargusch, R., Ehren, J.L., and Chiruta, C., The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice, Alzheimers Res. Ther., 2013, vol. 5, no. 3, pp. 25–30.
Rogers, J.T., Liu, C.C., Zhao, N., et al., Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiol. Aging, 2017, vol. 53, pp. 112–121.
Rossi, D.J., Bryder, D., Seita, J., et al., Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age, Nature, 2007, vol. 447, pp. 725–729.
Salmon, A.B., Dorigatti, J., Huber, H.F., et al., Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions, Geroscience, 2018, vol. 40, no. 3, pp. 269–278.
Samovski, D., Sun, J., Pietka, T., et al., Regulation of AMPK activation by CD36 links fatty acid uptake to β‑oxidation, Diabetes, 2015, vol. 64, no. 2, pp. 353–359.
Sarkar, Т.J., Quarta, M., Mukherjee, S., et al., Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells, Nat Commun 11, 1545 (2020). https://www.biorxiv.org/content/10.1101/573386v1
Shallis, R.M., Boddu, P.C., Bewersdorf, J.P., and Zeidan, A.M., The golden age for patients in their golden years: the progressive upheaval of age and the treatment of newly-diagnosed acute myeloid leukemia, Blood Rev., 2020, vol. 40, p. 100639.
Shay, J.W., Telomeres and aging, Curr. Opin. Cell Biol., 2018, vol. 52, pp. 1–7.
Sinclair, D.A., Steegborn, C., Aravind, L., and Gorbunova, V., A conserved NAD+ binding pocket that regulates protein–protein interactions during aging, Science, 2017, vol. 355, pp. 1312–1317.
Soares, M.J., Iqbal, K., and Kozai, K., Hypoxia and placental development, Birth. Defects Res., 2017, vol. 109, no. 17, pp. 1309–1329.
Srinivas, N., Rachakonda, S., and Kumar, R., Telomeres and telomere length: a general overview, Cancers, 2020, vol. 12, no. 3, p. 558.
Sundarraj, K., Raghunath, A., and Perumal, E., A review on the chemotherapeutic potential of fisetin: In vitro evidences, Biomed. Pharmacother., 2018, vol. 97, pp. 928–940.
Than, N.G., Romero, R., Tarca, A.L., et al., Integrated systems biology approach identifies novel maternal and placental pathways of preeclampsia, Front. Immunol., 2018, vol. 9, pp. 1661–1670.
Thomas, I. and Gregg, B., Metformin; a review of its history and future: from lilac to longevity, Pediatr. Diabetes, 2017, vol. 18, no. 1, pp. 10–16.
Tompkins, B.A., DiFede, D.L., Khan, A., et al., Allogeneic mesenchymal stem cells ameliorate aging frailty: a phase II randomized, double-blind, placebo-controlled clinical trial, J. Gerontol. A Biol. Sci. Med. Sci., 2017, vol. 72, no. 11, pp. 1513–1522.
Tsyvian, P.B., Bashmakova, N.V., Kovtun, O.P., and Makarenko, L.V., Maternal and newborn infants amino acid concentrations in obese women born themselves with normal and small for gestational age birth weight, J. Dev. Orig. Health Dis., 2015, vol. 6, no. 4, pp. 278–284.
Tsyvian, P.B., Markova, T.V., Mikhailova, S.V., and Hop, W.C., Left ventricular isovolumic relaxation and renin–angiotensin system in the growth restricted fetus, Europ. J. Obstet. Gynec. Reprod. Biol., 2008, vol. 140, no. 1, pp. 33–37.
Vaiserman, A., Koliada, A., and Lushchak, O., Developmental programming of aging trajectory, Ageing Res. Rev., 2018, no. 47, pp. 105–122.
Vassilopoulos, A., Pennington, J.D., Andresson, T., et al., SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress, Antioxid. Redox. Signal., 2014, vol. 21, no. 4, pp. 551–564.
Vijg, J., Dong, X., Milholland, B., and Zhang, L., Genome instability: A conserved mechanism of ageing?, Essays Biochem., 2017, vol. 61, no. 3, pp. 305–315.
Vitale, G., Pellegrino, G., Vollery, M., and Hofland, L.J., Role of IGF-1 system in the modulation of longevity: controversies and new insights from a centenarians’ perspective, Front. Endocr. (Lausanne), 2019, vol. 10, аrt. 27. https://doi.org/10.3389/fendo.2019.00027
Vlad, S.C., Miller, D.R., Kowall, N.W., and Felson, D.T., Protective effects of NSAIDs on the development of Alzheimer disease, Neurology, 2008, vol. 70, no. 19, pp. 1672–1677.
Weichhart, T., mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review, Gerontology, 2018, vol. 64, no. 2, pp. 127–134.
Yakar, S. and Adamo, M.L., Insulin-like growth factor 1 physiology: lessons from mouse models, Endocr. Metab. Clin. North Amer., 2012, no. 41, pp. 231–247.
Yang, B., Zwaans, B.M., Eckersdorff, M., and Lombard, D.B., The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability, Cell Cycle, 2009, vol. 16, no. 8, pp. 2662–2663.
Yousef, H., Conboy, M.J., Morgenthaler, A., et al., Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal, Oncotarget, 2015, vol. 14, no. 6, pp. 11 959–11 978.
Yousefzadeh, M.J., Zhu, Y., McGowan, S.J., et al., Fisetin is a senotherapeutic that extends health and lifespan, E. Bio. Med., 2018, vol. 36, pp. 18–28.
Zhao, L. and Sumberaz, P., Mitochondrial DNA damage: prevalence, biological consequence, and emerging pathways, Chem. Res. Toxicol., 2020, vol. 33, no. 10, pp. 2491–2502.
The paper was supported as a part of the state task the Ministry of Health of the Russian Federation for 2021–2023, registration no. 121030900298-9 “Individualization of the selection of complex geroprophylactic therapy.”
The authors declare that they have no conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.
Translated by P. Kuchina
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Meshchaninov, V.N., Tsyvian, P.B., Myakotnykh, V.S. et al. Ontogenetic Principles of Accelerated Aging and the Prospects for Its Prevention and Treatment. Adv Gerontol 12, 294–304 (2022). https://doi.org/10.1134/S2079057022030080
- accelerated aging