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Ultradian Rhythms and Oxidative Stress in Lymph-Node Tissue during Ontogenesis

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Abstract

Age-related features of the ultradian rhythms of the total protein and albumin content in lymph-node tissue have been studied in intact rats and rats exposed to chronic toxic oxidative stress with a chronobiological approach and biochemical methods. During the experiment, the rhythmic activity of the total protein and the albumin content in lymph nodes were compared during ontogenesis and under chronic exposure to a sulfur-containing natural gas. The revealed oscillations in the studied parameters can be characterized as circahoralian (ultradian) with periods of 20–40 to 60 min. The obtained data indicate a decrease in the adaptive resistance of lymph nodes and exhaustion of the antioxidant system in aging rats. These results can be of practical value for the development of methods to correct for the negative effects of a toxic oxidative stress during ontogenesis.

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Funding

The study was performed within the framework of the State Assignment no. АААА-А18-118012290371-3.

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Authors and Affiliations

  1. Astrakhan State Medical University, 414000, Astrakhan, Russia

    I. S. Rozhkova

  2. Astrakhan State University, 414000, Astrakhan, Russia

    D. L. Teply & E. D. Bazhanova

  3. Golikov Research Center of Toxicology, 192019, St. Petersburg, Russia

    E. D. Bazhanova

  4. Sechenov Institute of Evolutionary Physiology and Biochemistry, 194223, St. Petersburg, Russia

    E. D. Bazhanova

Authors
  1. I. S. Rozhkova
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  2. D. L. Teply
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  3. E. D. Bazhanova
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Correspondence to E. D. Bazhanova.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement of animal welfare. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by N. Statsyuk

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Rozhkova, I.S., Teply, D.L. & Bazhanova, E.D. Ultradian Rhythms and Oxidative Stress in Lymph-Node Tissue during Ontogenesis. Adv Gerontol 11, 268–273 (2021). https://doi.org/10.1134/S2079057021030140

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  • DOI: https://doi.org/10.1134/S2079057021030140

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