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Analytical Study of Patterns of the Survival Curves of Experimental Objects in Model Experiments on Daphnia magna

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Abstract

The phenomenon of multiphasic survival curves found in drosophila is confirmed in experiments on daphnids. Mathematical modeling showed that the multiphasic nature of daphnids survival curves reflected abrupt changes in the death rate of objects during phase transition. The phase of a sharp increase in mortality observed at an early age in intact drosophila occurs in daphnids only as reaction to a negative impact. The induction of reactive changes by weak external signals resulted in decreased survival for young daphnids. A logical conclusion was made about the reaction readiness for each experimental individual. It is proven that the predisposition to reaction in daphnia persists for an indefinitely large number of generations. It is postulated that this reaction has an epigenetic nature. Earlier experimental materials suggest that a reaction of this type is widespread in natural surroundings.

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ACKNOWLEDGMENTS

The authors are grateful to A.M. Olovnikov for participation in the discussion of the results of the study and its prospects; S.V. Mylnikov, who has coauthored numerous studies on drosophila; the editorial board of the journal Advances in Gerontology for publishing a series of works that served as the basis for this study, and I.A. Solovyov for recommending interesting publications within the Research Gate social network.

Funding

SEI work, in part, was supported by the MEPhI Academic Excellence Project (no. 02.a03.21.0005), as well as planned studies of the authors.

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Authors and Affiliations

  1. Trapeznikov Institute of Control Sciences, Russian Academy of Sciences, 117997, Moscow, Russia

    A. I. Michalski

  2. Obninsk Institute of Atomic Energy, 249040, Obninsk, Kaluga region, Russia

    N. B. Savina & E. I. Sarapultseva

  3. National Research Nuclear University, Moscow Engineering Physics Institute (MEPhI), 115409, Moscow, Russia

    E. I. Sarapultseva

  4. A. Tsyb Medical Radiological Research Center—Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036, Obninsk, Russia

    E. I. Sarapultseva

  5. Nikiforov All-Russia Center for Emergency and Radiation Medicine (EMERCOM) of Russia, 194044, St. Petersburg, Russia

    I. B. Bychkovskaya

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  1. A. I. Michalski
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Correspondence to A. I. Michalski.

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Statement on animal welfare. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by L. Solovyova

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Michalski, A.I., Savina, N.B., Sarapultseva, E.I. et al. Analytical Study of Patterns of the Survival Curves of Experimental Objects in Model Experiments on Daphnia magna . Adv Gerontol 11, 101–112 (2021). https://doi.org/10.1134/S2079057021010434

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