Astragalus membranaceus (webbed astragalus) has been used in traditional Chinese medicine for more than two millennia to slow the aging process and increase the life span. The article analyzes data on experimental and clinical studies from recent years that reveal the possible mechanisms of the antiaging effects of this plant. It is noted that the extract or different groups of chemical compounds of this plant activate telomerase, inhibit the processes of replicative senescence, possess antioxidant activity, have a neuroprotective effect, and affect the processes of age-related macular degradation, skin photoaging, and alopecia.
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Anisimov, S.V., Use of stem cells in age-related neurodegenerative pathology: experimental study, Extended Abstract of Doctoral (Med.) Dissertation, St. Petersburg, 2011.
Batotsyrenova, E.T., Toropova, A.A., Tankhaeva, L.M., et al., Membrane-stabilizing and antioxidant activity of the dry extract of Astragalus membranaceus, Vestn. Buryat. Gos. Univ., Med. Farm., 2012, no. 12, pp. 15–18.
Gritsenko, D.A., Orlova, O.A., Linkova, N.S., and Khavinson, V.K., Transcription factor p53 and skin aging, Adv. Gerontol., 2017, vol. 7, no. 2, pp. 114–119.
Emel’yanov, V.V., Glycation, antiglycation, and deglycation: their role in aging mechanisms and geroprotective effects (literature review), Adv. Gerontol., 2017, vol. 7, no. 1, pp. 1–9.
Kovalenko, N.A., Zhdanov, D.D., and Kovalenko, T.F., Possibilities and effects of telomerase activation, Mol. Biol. (Moscow), 2013, vol. 47, no. 4, pp. 476–487.
Kubanov, A.A., Zhilova, M.B., and Kubanova, A.A., Photo-aging of the skin: development mechanisms and clinical manifestations, Vestn. Dermatol. Venerol., 2014, no. 5, pp. 53–59.
Maximov, V.N., Malyutina, S.K., Orlov, P.S., et al., Leukocyte telomere length as an aging marker and risk factor for human age-related diseases, Adv. Gerontol., 2017, vol. 7, no. 2, pp. 101–106.
Nazhmutdinova, D.K. and Takha, T.V., Alopecia: diagnosis and treatment, Med. Sov., 2010, nos. 5–6, pp. 87–91.
Smirnova, I.O., Skin photo-aging—molecular markers of epidermis and dermis, Usp. Gerontol., 2004, vol. 17, no. 15, pp. 62–69.
Snarskaya, E.S., Modern aspects of skin photoaging, Vestn. Dermatol. Venerol., 2011, no. 2, pp. 98–103.
Telegina, D.V., Fursova, A.Zh., Kolosova, N.G., and Kozhevnikova, O.S., Expression of nitric oxide synthases in the retina of OXYS rats during retinopathy development, Usp. Gerontol., 2014, vol. 27, no. 1, pp. 87–93.
Toropova, A.A., Batotsyrenova, E.T., Olennikov, D.N., et al., Antioxidant activity of dry extract of underground organs of Astragalus membranaceus and its fractions, Sib. Med. Zh., 2012, no. 7, pp. 107–109.
Toropova, A.A., Lemza, S.V., Azhunova, T.A., and Khabaeva, O.V., Antioxidant activity of dry extract of Astragalus membranaceus (Fisch) Bunge in enxymatic test-systems, Vestn. Buryat. Gos. Univ., Med. Farm., 2013, no. 12, pp. 24–27.
Trubitsyn, A.G., The joined aging theory, Adv. Gerontol., 2013, vol. 3, no. 3, pp. 155–172.
Shreter, A.I., Valentinov, B.G., and Naumova, E.M., Prirodnoe syr’e kitaiskoi meditsyny (Natural Raw Material Used in Chinese Medicine), Moscow, 2004, vol. 1.
Shurygina, L.V., Kravtsov, A.A., Kozin, S.V., et al., Antioxidant activity of extracts from roots and aerial parts of Astragalus membranaceus (Fabaceae) in two model systems, Rastit. Resur., 2017, vol. 63, no. 2, pp. 291–299.
Al-Ajmi, N., Saretzki, G., Miles, C., and Spyridopoulos, I., Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype, Exp. Gerontol., 2014, vol. 58, pp. 113–119.
Amro, A., Wandel, T.L., and Sharma, S., Isoflurane induces neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane, Open Ophthalmol. J., 2018, vol. 3, no. 2, p. 000146.
Bao, H., Sun, D., Qi, P., and Jiang, S., Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5, Biomed. Pharmacother., 2019, vol. 109, pp. 1826–1833.
Beatty, S., Koh, H., Phil, M., et al., The role of oxidative stress in the pathogenesis of age-related macular degeneration, Surv. Ophthalmol., 2000, vol. 45, no. 2, pp. 115–134.
Bernardes de Jesus, B., Schneeberger, K., Vera, E., et al., The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence, Aging Cell, 2011, vol. 10, no. 4, pp. 604–621.
Chan, W.S., Durairajan, S.S., Lu, J.H., et al., Neuroprotective effects of astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture, Neurochem. Int., 2009, vol. 55, no. 6, pp. 414–422.
Chen, B., Li, R., Yan, N., et al., Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1, Mol. Med. Rep., 2015, vol. 11, no. 5, pp. 3344–3348.
Chen, P.J., Shang, A.Q., Wang, W.W., and Yang, J.P., Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane, J. Cell. Biochem., 2019, vol. 120, no. 1, pp. 1028–1037.
Cheng, C.Y., Yao, C.H., Liu, B.S., et al., The role of astragaloside in regeneration of the peripheral nerve system, J. Biomed. Mater. Res., Part A, 2006, vol. 76, no. 3, pp. 463–469.
Cheung, L.K. and Eaton, A., Age-related macular degeneration, Pharmacotherapy, 2013, vol. 33, no. 8, pp. 838–855.
Dow, C.T. and Harley, C.B., Evaluation of an oral telomerase activator for early age-related macular degeneration—a pilot study, Clin. Ophthalmol., 2016, vol. 10, pp. 243–249.
Fernandez, M.L., Thomas, M.S., Lemos, B.S., et al., TA-65, a telomerase activator improves cardiovascular markers in patients with metabolic syndrome, Curr. Pharm. Des., 2018, vol. 24, no. 17, pp. 1905–1911.
Fauce, S.R., Jamieson, B.D., Chin, A. C., et al., Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes, J. Immunol., 2008, vol. 181, no. 10, pp. 7400–7406.
Guo, L., Wei, X.D., Ou, Q., et al., Effect of astragaloside on the expression of telomerase activity and klotho gene in aged HELF cells, Chin. J. Gerontol., 2010, no. 13, pp. 1819–1822.
Harley, C.B., Liu, W., Blasco, M., et al., A natural product telomerase activator as part of a health maintenance program, Rejuvenation Res., 2011, vol. 14, no. 1, pp. 45–56.
Hong, M.J., Ko, E.B., Park, S.K., and Chang, M.S., Inhibitory effect of Astragalus membranaceus root on matrix metallopro teinase-1 collagenase expression and procollagen destruction in ultraviolet B-irradiated human dermal fibroblasts by suppressing nuclear factor κ‑B activity, J. Pharm. Pharmacol., 2013, vol. 65, no. 1, pp. 142–148.
Huang, F., Lan, Y., Qin, L., et al., Astragaloside IV promotes adult neurogenesis in hippocampal dentate gyrus of mouse through CXCL1/CXCR2 signaling, Molecules, 2018, vol. 23, no. 9, p. E2178.
Ip, F.C., Ng, Y.P., An, H.J., et al., Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management, Neurosignals, 2014, vol. 22, no. 1, pp. 52–63.
Kim, J.H., Kim, M.R., Lee, E.S., and Lee, C.H., Inhibitory effects of calycosin isolated from the root of Astragalus membranaceus on melanin biosynthesis, Biol. Pharm. Bull., 2009, vol. 32, no. 2, pp. 264–268.
Kim, M.H., Kim, S.H., and Yang, W.M., Beneficial effects of astragaloside IV for hair loss via inhibition of Fas/Fas L-mediated apoptotic signaling, PLoS One, 2014, vol. 9, no. 3, p. e92984.
Li, X.T., Zhang, Y.K., Kuang, H.X., et al., Mitochondrial protection and anti-aging activity of Astragalus polysaccharides and their potential mechanism, Int. J. Mol. Sci., 2012, vol. 13, no. 2, pp. 1747–1761.
Liu, P., Zhao, H., and Luo, Y., Anti-aging implications of Astragalus membranaceus (Huangqi): a well-known Chinese tonic, Aging Dis., 2017, vol. 8, no. 6, pp. 868–886.
Liu, X. and Min, W., Protective effects of astragaloside against ultraviolet A-induced photoaging in human fibroblasts, Zhong Xi Yi Jie He Xue Bao, 2011, vol. 9, no. 3, pp. 328–332.
Liu, X, Zhang, J., Wang, S., et al., Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells by inhibiting α-synuclein expression via the p38 MAPK pathway, Int. J. Mol. Med., 2017, vol. 40, no. 6, pp. 1772–1780.
Ma, X., Zhang, K., Li, H., et al., Extracts from Astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia, J. Ethnopharmacol., 2013, vol. 149, no. 3, pp. 720–728.
Mariani, E., Meneghetti, A., Formentini, I., et al., Telomere length and telomerase activity: effect of ageing on human NK cells, Mech. Ageing Dev., 2003, vol. 124, no. 4, pp. 403–408.
Molgora, B., Bateman, R., Sweeney, G., et al., Functional assessment of pharmacological telomerase activators in human T cells, Cells, 2013, vol. 2, no. 1, pp. 57–66.
Park, H.J. and Park, S.H., Induction of apoptosis by ethyl acetate fraction of Astragalus membranaceus in human non-small cell lung cancer cells, J. Pharmacopuncture, 2018, vol. 21, no. 4, pp. 268–276.
Salvador, L., Singaravelu, G., Harley, C.B., et al., A natural product telomerase activator lengthens telomeres in humans. A randomized, double blind and placebo controlled study, Rejuvenation Res., 2016, vol. 19, no. 6, pp. 478–484.
Shen, C.Y., Jiang, J.G., Yang, L., et al., Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery, Br. J. Pharmacol., 2017, vol. 174, no. 11, pp. 1395–1425.
Tsao, Y.T., Kuo, C.Y., Kuan, Y.D., et al., The extracts of Astragalus membranaceus inhibit melanogenesis through the ERK signaling pathway, Int. J. Med. Sci., 2017, vol. 14, no. 11, pp. 1049–1053.
Wang, J.J., Li, J., Shi, L., et al., Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride-induced hepatic fibrosis, J. Pharm. Pharmacol., 2010, vol. 62, no. 7, pp. 935–942.
Wang, P., Zhang, Z., and Ma, X., HDTIC-1 and HDTIC-2, two compounds extracted from Astragali radix, delay replicative senescence of human diploid fibroblasts, Mech. Ageing Dev., 2003, vol. 124, nos. 10–12, pp. 1025–1034.
Wang, P., Zhang, Z., Sun, Y., et al., The two isomers of HDTIC compounds from Astragali radix slow down telomere shortening rate via attenuating oxidative stress and increasing DNA repair ability in human fetal lung diploid fibroblast cells, DNA Cell Biol., 2010, vol. 29, no. 1, pp. 33–39.
Wen, W., Chen, J., Ding, L., et al., Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy, Arch. Biochem. Biophys., 2018, vol. 657, pp. 31–40.
Xia, L., Guo, D., and Chen, B., Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes, Exp. Ther. Med., 2017, vol. 14, no. 6, pp. 5569–5575.
Yang, B., Ji, C., Chen, X., et al., Protective effect of astragaloside IV against matrix metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts, Arch. Pharm. Res., 2011, vol. 34, no. 9, pp. 1553–1560.
Yang, W.T., Zheng, X.W., Chen, S., et al., Chinese herbal medicine for Alzheimer’s disease: clinical evidence and possible mechanism of neurogenesis, Biochem. Pharmacol., 2017, vol. 141, pp. 143–155.
Zhang, X.H. and Chen, J.J., The mechanism of astragaloside IV promoting sciatic nerve regeneration, Neural Regener. Res., 2013, vol. 8, no. 24, pp. 2256–2265.
Zhao, L.H., Ma, Z.X., Zhu, J., et al., Characterization of polysaccharide from Astragalus radix as the macrophage stimulator, Cell. Immunol., 2011, vol. 271, no. 2, pp. 329–334.
Zhu, G.M., Jiang, X.D., Wang, D.D., et al., Effect of Astragalus membranaceus polysaccharide on chromosome terminal restriction fragment length of the aged HDF cell, Chin. J. Gerontol., 2012, no. 8, pp. 1635–1637.
Conflict of interests. The authors declare that they have no conflicts of interest.
Statement on the welfare of animals. This article does not contain any studies involving animals performed by any of the authors.
Translated by A. Barkhash
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Berezutsky, M.A., Durnova, N.A. & Vlasova, I.A. Experimental and Clinical Studies of Mechanisms of the Antiaging Effects of Chemical Compounds in Astragalus membranaceus (Review). Adv Gerontol 10, 142–149 (2020). https://doi.org/10.1134/S2079057020020046