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Comparative Analysis of Experimental Data on the Effects of Different Polyphenols on Lifespan and Aging

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Abstract

Survival curves were approximated and analyzed based on experimental data on the effect of different polyphenolic compounds on mouse lifespan with the Gompertz model in its minimal variant, which excludes the parameters of sample heterogeneity and age-independent mortality. Vectors from the control data towards the experimental data were plotted on graphs with coordinates [logμ0 (the logarithm of initial mortality) and γ (the rate of aging)] and compared with a series of control points. The deviations were considered real when the tilt angles of the corresponding vectors differed from those of the logμ0 regressions on the γ coordinate based on the control data. The results of analysis of the published data have shown that resveratrol, tocopherol, polyphenol-containing grape skin extract, SkQ1 antioxidant, and metformin do not result in any differences between the control and experimental data beyond the limits expected in the comparison of different samples of the same control population. Unlike the indicated preparations, the complex polyphenol preparation BP-C3 acts differently and decelerates aging in female SHR mice. It is the antioxidant activity of BP-C3 that may partly be associated with this effect. We have determined its antioxidant capacity in vitro, and demonstrated its ability when administered in vivo to hinder a decrease in the total peroxide-decomposing activity in the erythrocytes of male BALB/c mice treated with 5-fluorouracil.

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REFERENCES

  1. Anisimovich, I.P., Deineka, V.I., Deineka, L.A., et al., The parameters of the antioxidant activity of the compounds: the relative antioxidant activity of tea, Nauchn. Ved. Belgorod. Gos. Univ.,Ser. Estestv. Nauki, 2010, vol. 9, no. 11, pp. 104–110.

    Google Scholar 

  2. Vladimirov, Yu.A. and Archakov, I.M., Perekisnoe okislenie lipidov v biologicheskikh membranakh (Lipid Peroxidation in Biological Membranes), Moscow: Nauka, 1972, pp. 241–242.

  3. Korolyuk, M.A., Ivanova, L.I., Maiorova, I.G., and Tokarev, V.E., Determination of catalase activity, Lab. Delo, 1988, no. 1, pp. 16–19.

  4. Sirota, T.V., A new approach to the study of the autooxidation of adrenaline and its use to measure the activity of superoxide dismutase, Vopr. Med. Khim., 1999, no. 3, pp. 263–272.

  5. Anantharaju, P.G., Gowda, P.C., Vimalambike, M.G., and Madhunapantula, S.V., An overview on the role of dietary phenolics for the treatment of cancers, Nutr. J., 2016, vol. 15, no. 1, p. 99.

    Article  Google Scholar 

  6. Andrijevic, L., Radotic, K., Bogdanovic, J., et al., Antiproliferative effect of synthetic lignin against human breast cancer and normal fetal lung cell lines. Potency of low molecular weight fractions, J. Buon., 2008, vol. 13, no. 2, pp. 241–244.

    PubMed  Google Scholar 

  7. Anisimov, V.N., Berstein, L.M., Popovich, I.G., et al., If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice, Aging (N.Y.), 2011, vol. 3, no. 2, pp. 148–157.

    Article  CAS  Google Scholar 

  8. Anisimov, V.N., Egorov, M.V., Krasilshchikova, M.S., et al., Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents, Aging (N.Y.), 2011, vol. 3, no. 11, pp. 1110–1119.

    Article  CAS  Google Scholar 

  9. Anisimov, V.N., Popovich, I.G., Zabezhinski, M.A., et al., Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice, Aging (N.Y.), 2016, vol. 8, no. 9, pp. 1866–1875.

    Article  CAS  Google Scholar 

  10. Asseburg, H., Schafer, C., Muller, M., et al., Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice, Neuromol. Med., 2006, vol. 18, no. 3, pp. 378–395.

    Article  Google Scholar 

  11. Banks, R., Speakman, J.R., and Selman, C., Vitamin E supplementation and mammalian lifespan, Mol. Nutr. Food Res., 2010, vol. 54, no. 5, pp. 719–725.

    Article  CAS  Google Scholar 

  12. Conti, V., Izzo, V., Corbi, G., et al., Antioxidant supplementation in the treatment of aging-associated diseases, Front. Pharmacol., 2016, vol. 7, p. 24.

    Article  Google Scholar 

  13. Cory, H., Passarelli, S., Szeto, J., et al., The role of polyphenols in human health and food systems: a mini-review, Front. Nutr., 2018, vol. 5, p. 87.

    Article  Google Scholar 

  14. Dutta, S., Sadhukhan, P., Saha, S., and Sil, P.C., Regulation of oxidative stress by different naturally occurring polyphenolic compounds: an emerging anticancer therapeutic approach, React. Oxygen Species, 2017, vol. 3, no. 8, p. 15.

    Google Scholar 

  15. Ernst, I.M., Pallauf, K., Bendall, J.K., et al., Vitamin E supplementation and lifespan in model organisms, Ageing Res. Rev., 2013, vol. 12, no. 1, pp. 365–375.

    Article  CAS  Google Scholar 

  16. Fedoros, E.I., Orlov, A.A., Zherebker, A., et al., Novel watersoluble lignin derivative BP-Cx-1: identification of components and screening of potential targets in silico and in vitro, Oncotarget, 2018, vol. 9, no. 26, pp. 18578–18593.

    Article  Google Scholar 

  17. Golubev, A., Panchenko, A., and Anisimov, V., Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common sense, Biogerontology, 2018, vol. 19, pp. 341–365.

    Article  CAS  Google Scholar 

  18. Hector, K.L., Lagisz, M., and Nakagawa, S., The effect of resveratrol on longevity across species: a meta-analysis, Biol. Lett., 2012, vol. 8, no. 5, pp. 790–793.

    Article  CAS  Google Scholar 

  19. Kitani, K., Osawa, T., and Yokozawa, T., The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice, Biogerontology, 2007, vol. 8, no. 5, pp. 567–573.

    Article  CAS  Google Scholar 

  20. Luna-Guevara, M.L., Luna-Guevara, J.J., Hernández-Carranza, P., et al., Phenolic compounds: a good choice against chronic degenerative diseases, in Studies in Natural Products Chemistry, Atta-ur-Rahman, Ed., Amsterdam: Elsevier, 2018, vol. 59, chap. 3, pp. 79–108.

  21. Mitchell, S.J., Madrigal-Matute, J., Scheibye-Knudsen, M., et al., Effects of sex, strain, and energy intake on hallmarks of aging in mice, Cell Metab., 2016, vol. 23, pp. 1093–1112.

    Article  CAS  Google Scholar 

  22. Montero, M., De la Fuente, S., Fonteriz, R.I., et al., Effects of long-term feeding of the polyphenols resveratrol and kaempferol in obese mice, PLoS One, 2014, vol. 9, no. 11, p. e112825.

    Article  Google Scholar 

  23. Morley, A.A. and Trainor, K.J., Lack of an effect of vitamin E on lifespan of mice, Biogerontology, 2001, vol. 2, no. 2, pp. 109–112.

    Article  CAS  Google Scholar 

  24. Nabavi, S.F., Sureda, A., Dehpour, A.R., et al., Regulation of autophagy by polyphenols: paving the road for treatment of neurodegeneration, Biotechnol. Adv., 2018, vol. 36, no. 6, pp. 1768–1778.

    Article  CAS  Google Scholar 

  25. Ozdal, T., Sela, D.A., Xiao, J., et al., The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility, Nutrients, 2016, vol. 8, no. 2, pp. 78.

    Article  Google Scholar 

  26. Pearson, K.J., Baur, J.A., Lewis, K.N., et al., Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span, Cell Metab., 2008, vol. 8, no. 2, pp. 157–168.

    Article  CAS  Google Scholar 

  27. Queen, B.L. and Tollefsbol, T.O., Polyphenols and aging, Curr. Aging Sci., 2010, vol. 3, no. 1, pp. 34–42.

    Article  CAS  Google Scholar 

  28. Rahnasto-Rilla, M., Tyni, J., Huovinen, M., et al., Natural polyphenols as sirtuin 6 modulators, Sci. Rep., 2018, vol. 8, no. 1, p. 4163.

    Article  Google Scholar 

  29. Sadowska-Bartosz, I. and Bartosz, G., Effect of antioxidants supplementation on aging and longevity, Biomed. Res. Int., 2014, vol. 2014, art. ID 404680.

    Article  Google Scholar 

  30. Sandoval-Ramirez, B.A., Lamuela-Ravent, R.M., Estruch, R., et al., Beer polyphenols and menopause: effects and mechanisms—a review of current knowledge, Oxidative Med. Cell. Longevity, 2017, vol. 2017, art. ID 4749131.

  31. Selman, C., McLaren, J.S., Mayer, C., et al., Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage, Rejuvenation Res., 2008, vol. 11, no. 1, pp. 83–96.

    Article  CAS  Google Scholar 

  32. Tarkhov, A.E., Menshikov, L.I., and Fedichev, P.O., Strehler-Mildvan correlation is a degenerate manifold of Gompertz fit, J. Theor. Biol., 2017, vol. 416, pp. 180–189.

    Article  Google Scholar 

  33. Urpi-Sarda, M., Andres-Lacueva, C., Rabassa, M., et al., The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: The InCHIANTI study, J. Gerontol. A, 2015, vol. 70, no. 9, pp. 1141–1147.

    Article  CAS  Google Scholar 

  34. Vinardell, M.P. and Mitjans, M., Lignins and their derivatives with beneficial effects on human health, Int. J. Mol. Sci., 2017, vol. 18, no. 6. pii E1219

    Article  Google Scholar 

  35. Yao, J., Zhang, B., Ge, C., et al., Xanthohumol, a polyphenol chalcone present in hops, activating Nrf2 enzymes to confer protection against oxidative damage in PC12 cells, J. Agric. Food Chem., 2015, vol. 63, no. 5, pp. 1521–1531.

    Article  CAS  Google Scholar 

  36. Yeh, W.-J., Hsia, S.-M., Lee, W.-H., and Wu, C.-H., Polyphenols with antiglycation activity and mechanisms of action: a review of recent findings, J. Food Drug Anal., 2017, vol. 25, no. 1, pp. 84–92.

    Article  CAS  Google Scholar 

  37. Zhou, Y., Zheng, J., Li, Y., et al., Natural polyphenols for prevention and treatment of cancer, Nutrients, 2016, vol. 8, no. 8. pii E515

    Article  Google Scholar 

  38. Zujko, M.E., Waskiewicz, A., Witkowska, A.M., et al., Dietary total antioxidant capacity and dietary polyphenol intake and prevalence of metabolic syndrome in polish adults: a nationwide study, Oxidative Med. Cell. Longevity, 2018, vol. 2018, art. ID 7487816.

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Authors and Affiliations

  1. Petrov National Medical Research Center of Oncology, 197758, St. Petersburg, Russia

    A. V. Panchenko, M. L. Tyndyk, E. I. Fedoros, M. A. Maydin, A. L. Semenov, E. A. Gubareva, A. G. Golubev & V. N. Anisimov

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  1. A. V. Panchenko
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  2. M. L. Tyndyk
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  3. E. I. Fedoros
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  4. M. A. Maydin
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  5. A. L. Semenov
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  6. E. A. Gubareva
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  7. A. G. Golubev
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  8. V. N. Anisimov
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Correspondence to A. V. Panchenko.

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Translated by N. Tarasyuk

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Panchenko, A.V., Tyndyk, M.L., Fedoros, E.I. et al. Comparative Analysis of Experimental Data on the Effects of Different Polyphenols on Lifespan and Aging. Adv Gerontol 9, 396–401 (2019). https://doi.org/10.1134/S2079057019040131

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  • DOI: https://doi.org/10.1134/S2079057019040131

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