Advances in Gerontology

, Volume 9, Issue 1, pp 86–90 | Cite as

Ontogenetic Characteristics of Patients with Erectile Dysfunction with Different Types of Aging

  • V. I. OdinEmail author
  • V. I. Didenko


Age-related erectile dysfunction (ED) can form during ontogenesis in accordance with various mechanisms of the pathogenesis of aging in conjunction with a particular cluster of diseases. The goal of this work is to study the ontogenetic features of ED patients in late ontogeny who vary by types of aging. The study comprised 65 men over 45 years old with an explicit form of ED. The first group consisted of patients with general somatic diseases (GSDs) following the accumulative model of aging, and the second group included patients with age-associated diseases (AADs) that arose primarily from the ontogenetic model of aging. Both types of age-related ED are closely connected with ontogenetic events, especially with the onset of obesity and the loss of morning erections (which precede the onset of ED), on average over a decade of life. ED with AADs is the most clinically and pathogenetically compromised. Thus, it is characterized by an earlier age of ED onset, a dysmetabolic pattern, a low geroprotective pattern, a poor quality of primary health, pronounced instability of the gonadostat, a weak sexual constitution, decreased sensitivity of the hypothalamic-pituitary complex to feedback signals, and a large proliferative pattern. ED associated with GSDs had a later age of ED onset, developed much later from the onset of obesity, and had a lower level of testicular volume with a more conserved incretory function but a higher index of IPSS. Therefore, the separation of two ED variants associated with different types of aging in conjunction with the use of ontogenetic analysis allowed the identification of significant differences in clinical and pathogenic forms, which is important for the development of ideas on the diagnosis and treatment of age-related ED.


aging ontogeny erectile dysfunction testosterone dehydroepiandrosterone sulfate centenarian metabolic syndrome obesity 



  1. 1.
    Vasil’chenko, G.S., Agarkova, T.E., Agarkov, S.T., et al., Seksopatologiya: Spravochnik (Sexopathology: Handbook), Moscow: Meditsina, 1990.Google Scholar
  2. 2.
    Dedov, I.I., Mel’nichenko, G.A., Rozhivanov, R.V., and Kurbatov, D.G., Recommendations for diagnostics and treatment of testosterone deficiency (hypogonadism) in men, Probl. Endokrinol., 2015, vol. 61, no. 5, pp. 60–71.CrossRefGoogle Scholar
  3. 3.
    Russian Society of Cardiology: National Guidelines on Metabolic Syndrome, Kardiovask. Ter. Profil., 2007, vol. 6, suppl. 6, pp. 1–26.Google Scholar
  4. 4.
    Dil’man, V.M., Chetyre modeli meditsiny (Four Models of Medicine), Leningrad: Meditsina, 1987.Google Scholar
  5. 5.
    Kad’yan, A.A., Naselenie Sankt-Peterburgskikh gradskikh bogadelen (materially k izucheniyu starosti po issledovaniyu, proizvedennomu pod rukovodstvom S.P. Botkina v 1889 g.) (Population of St. Petersburg City Almshouses: The Data for Study Elderly according to the Research of S.P. Botkin in 1889), St. Petersburg, 1890.Google Scholar
  6. 6.
    Odin, V.I., Gamayunova, V.B., and Bershtein, L.M., Content of dehydroepiandrosterone, testosterone and cortisol in newly diagnosed type 2 diabetes, Probl. Endokrinol., 1999, vol. 45, no. 5, pp. 18–21.Google Scholar
  7. 7.
    Odin, V.I., Gerontology crisis: question on primary health in the 20th century, Adv. Gerontol., 2011, vol. 1, no. 4, pp. 273–283.CrossRefGoogle Scholar
  8. 8.
    Odin, V.I., Didenko, V.I., Kochanova, E.A., et al., Types of aging and vegetative status of patients with erectile dysfunction in late ontogenesis, Vestn. Ross. Voen.-Med. Akad., 2017, vol. 3, no. 59, pp. 105–108.Google Scholar
  9. 9.
    Odin, V.I., Dvorovkin, A.E., Inamova, O.V., et al., Ontogenetic forms of rheumatoid arthritis associated with autoimmune thyroiditis, Usp. Gerontol., 2018, vol. 31, no. 1, pp. 126–131.Google Scholar
  10. 10.
    Brand, J.S., van der Tweel, I., Grobbee, D.E., et al., Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies, Int. J. Epidemiol., 2011, vol. 40, no. 1, pp. 189–207.CrossRefGoogle Scholar
  11. 11.
    Corona, G., Vignozzi, L., Sforza, A., et al., Obesity and late-onset hypogonadism, Mol. Cell. Endocrinol., 2015, vol. 418, pp. 120–133.CrossRefGoogle Scholar
  12. 12.
    Dilman, V.M., Development, Aging, and Disease. A New Rationale for and Intervention Strategy, Chur: Harwood Academic, 1994.Google Scholar
  13. 13.
    Handelsman, D.J. and Staraj, S., Testicular size: the effects of aging, malnutrition, and illness, J. Androl., 1985, vol. 6, no. 3, pp. 144–151.CrossRefGoogle Scholar
  14. 14.
    Heinemann, L.A.J., et al., The Aging Males’ Symptoms (AMS) scale: update and compilation of international versions, Health Qual. Life Outcomes, 2003, vol. 1, pp. 15–21.CrossRefGoogle Scholar
  15. 15.
    Jockenhovet, F., Male Hypogonadism, Bremen: Uni-Med, 2004.Google Scholar
  16. 16.
    Korenchevsky, V.G., Physiological and Pathological Ageing, Basel: S. Karger Verlag, 1961.Google Scholar
  17. 17.
    NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence, JAMA, J. Am. Med. Assoc., 1993, vol. 270, no. 1, pp. 83–90.Google Scholar
  18. 18.
    Quilter, M., Hodges, L., von Hurst, P., et al., Male sexual function in New Zealand: a population-based cross-sectional survey of the prevalence of erectile dysfunction in men aged 40–70 years, J. Sex. Med., 2017, vol. 14, no. 7, pp. 928–936.CrossRefGoogle Scholar
  19. 19.
    Rosen, R.C., Riley, A., Wagner, G., et al., The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction, Urology, 1997, vol. 49, no. 6, pp. 822–830.CrossRefGoogle Scholar
  20. 20.
    Tewari, R., Rajender, S., Natu, S.M., et al., Diet, obesity, and prostate health: are we missing the link?, J. Androl., 2012, vol. 33, no. 5, pp. 763–776.CrossRefGoogle Scholar

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© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Kirov Military Medical AcademySt. PetersburgRussia

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