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Advances in Gerontology

, Volume 9, Issue 1, pp 109–114 | Cite as

Structure and Cytoarchitectonics of Lymphoid Tissue in Appendiсes of Elderly and Senile People

  • G. G. AminovaEmail author
Article
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Abstract

The phenomenon of population aging has been observed in many countries in recent years due to the increase in human life expectancy. Therefore, studies of lymphoid tissue, which supports the immune processes in the human body, are now of particular importance. The lymphoid tissue of appendices from humans of age groups of 54–81 years and 26–35 years was histologically studied, and the results were statistically treated. The lymphoid tissue belonging to senile age groups showed reductions and rearrangements with partial integrity of the modified lymphoid nodules. The majority of nodules were without lighter-stained germinal centers, and the processes of blast transformation were preserved therein. Mitoses were observed in the central zones of nodules with lighter centers. Lymphocytes actively migrate to lymphatic capillaries. The condition of lymphoid tissue in the appendix depends on the individual body parameters. In some cases, the lymphoid tissue is completely reduced, and the organ’s lumen is closed.

Keywords:

appendix lymphoid tissue cells elderly and senile age 

Notes

REFERENCES

  1. 1.
    Aminova, G.G., Structurally-functional varieties of lymphoid nodules in organs of immunogenesis and other systems, Morfol. Ved., 2009, nos. 3–4, pp. 58–62.Google Scholar
  2. 2.
    Aminova, G.G., Grigorenko, D.E., and Sapin, M.R., Morphological features of interaction of lymphoid nodules, lymphoid capillaries, and migration of lymphocytes in the walls of gut and tracheas, Morfologiya, 2013, no. 1, pp. 48–52.Google Scholar
  3. 3.
    Afanas’ev, Yu.I., Nozdrin, V.I., and Subbotin, S.M., Lymphatic nodule appendix: a review, Arkh. Anat., 1983, vol. 85, no. 8, pp. 73–82.Google Scholar
  4. 4.
    Borodin, Yu.I., Gorchakova, O.V., and Gorchakov, V.N., Peripheral lymphoid structures: development and function, Morfologiya, 2016, vol. 150, no. 4, pp. 90–96.Google Scholar
  5. 5.
    Valenkevich, L.N., Gastroenterologiya v geriatrii (Gastroenterology in Geriatrics), Leningrad: Meditsina, 1987.Google Scholar
  6. 6.
    Eliseev, A.S., Morphological characteristics of age-related changes of the appendix and acute simple appendicitis in adults, Extended Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 1979.Google Scholar
  7. 7.
    Zlobina, I.A., Krivtsunov, A.N., Bogat, S.V., and Prashchayeu, K.I., Musculoskeletal system as a target organ of frailty processes, Adv. Gerontol., 2016, vol. 6, no. 2, pp 144–147.CrossRefGoogle Scholar
  8. 8.
    Lun’kova, L.K., Kanibol’tskii, A.A., and Makarova, O.V., Morphological and functional characteristics of the immune system organs during heroin addiction, in Aktual’nye voprosy morfogeneza v norme i patologii (Normal and Pathological Morphogenesis), Moscow: YuNIKOR, 2002, pp. 24–29.Google Scholar
  9. 9.
    Miroshnichenko, I.V., Stolpnikova, V.I., Levashova, T.V., et al., Characteristics of the immunity of long-living people and the choice of immunity markers, Usp. Gerontol., 2014, vol. 27, no. 3, pp. 452–457.Google Scholar
  10. 10.
    Nozdrin, V.I., Bakhshinyan, M.Z., and Subbotin, S.M., Effect of appendectomy on the antitumor effect of all-trans-methylretinoate, Bull. Exp. Biol. Med., 1982, vol. 93, no. 1, pp. 81–84.CrossRefGoogle Scholar
  11. 11.
    Rabotnikova, E.L., Endocrinocytes of the human fetal appendix, Arkh. Anat., 1988, vol. 95, no. 8, pp. 78–81.Google Scholar
  12. 12.
    Sakimbaev, E.R., Age-related anatomy of the group lymphatic nodules of the human appendix, Arkh. Anat., 1984, vol. 87, no. 8, pp. 60–64.Google Scholar
  13. 13.
    Sapin, M.R. and Nikityuk, D.B., Limfaticheskaya sistema i ee vazhneishaya rol v immunnykh protsessakh (Lymphatic System and Its Important Role in Immune Processes), Moscow: Meditsinskaya Kniga, 2014.Google Scholar
  14. 14.
    Shcherbakov, V.V., Lymphoid tissue of the human appendix and its cell composition in different age periods, Arkh. Anat., 1980, vol. 78, no. 6, pp. 56–60.Google Scholar
  15. 15.
    Bjerke, K. and Brandtzaeg, P., Distribution of immunoglobulin producing cell is different in normal human appendix and colon mucosa, Gut, 1986, vol. 27, pp. 667–674.CrossRefGoogle Scholar
  16. 16.
    Chakravarti, B. and Abraham, G.N., Aging and T-cell-mediated immunity, Mech. Ageing Dev., 1999, vol. 108, no. 3, pp. 183–206.CrossRefGoogle Scholar
  17. 17.
    Opstelten, D., Stikuer, K., Deenen, G.J., et al., Germinal centers and the B cell system: VI. Migration pattern of germinal center cells of the rabbit appendix, Cell Tissue Res., 1981, vol. 218, no. 1, pp. 59–66.CrossRefGoogle Scholar
  18. 18.
    Sansoni, P., Vescovini, R., and Fagnoni, F., T-cell in aging: relationship between loss of CD 95– and increase of CD 28– T-cells, Proc. 2nd European Congr. on Biogerontology “From Molecules to Humans,” Abstracts of Papers, St. Petersburg, 2000, pp. 25–28.Google Scholar

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© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Research Institute of Human MorphologyMoscowRussia

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