Abstract
This study presents the results of complex histomorphometric research of the features of age-related dynamics of bone tissue. We used as study material samples of the distal epiphysis and diaphysis of the left tibia from 348 male corpses aging from 0 to 90 years. The group of microosteometric features that have the strongest correlation with age is established in different age groups; their quantitative characteristics are given here. It has been clarified that the trends of age-related changes in the structural components of bone tissue correspond to the basic patterns of growth, remodeling, and depend on the species and their localization. Conceptual positions of age involution of bone tissue are proposed in this study.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Avrunin, A.S. and Doktorov, A.A., Characteristics of osteocyte line cells from bones formed instead of cartilage (long tubular bones) and connective tissue (skull bones), Morfologiya, 2016, vol. 149, no. 1, pp. 7–14.
Avtandilov, G.G., Vvedenie v kolichestvennuyu patologicheskuyu morfologiyu (Introduction to Quantitative Pathological Morphology), Moscow: Meditsina, 1980.
Avtandilov, G.G., Meditsinskaya morfometriya (Medical Morphometry), Moscow: Meditsina, 1990.
Glybochko, P.V., Pigolkin, Yu.I., Nikolenko, V.N., et al., Sudebno-meditsinskaya diagnostika vozrasta (Forensic Diagnostics of Age), Moscow: Mosk. Gos. Med. Univ. im. I.M. Sechenova, 2016.
Davydovskii, I.V., Gerontologiya (Gerontology), Moscow: Meditsina, 1966.
Lesnyak, O.M. and Benevolenskaya, L.I., Osteoporosis in the Russian Federation: problems and perspectives, Nauchno-Prakt. Revmatol., 2010, no. 5, pp. 14–19.
Lesnyak, O.M., Ershova, O.B., Belova, K.Yu., et al., Epidemiology of osteoporotic fractures in the Russian Federation and the Russian model FRAX, Osteoporoz Osteopatii, 2014, no. 3, pp. 3–8.
Malinin, V.L., Vozrastnye parametry mineral’noi plotnosti kostnoi tkani podrostkov i yunoshei Sankt-Peterburga (kliniko-statisticheskoe issledovanie) (Age-Related Parameters of Mineral Density of Bone Tissue of Adolescences and Young Men in St. Petersburg: Clinical and Statistical Study), St. Petersburg: S.-Peterb. Gos. Pediatr. Med. Univ., 2003.
Mikroskopicheskaya tekhnika: rukovodstvo dlya vrachei i laborantov (Microscopic Technique: Guide for Physicians and Laboratory Assistants), Moscow: Meditsina, 1996.
Revell, P.A., Pathology of Bone, New York: Springer-Verlag, 1986.
Pashkova, I.G., Gaivoronskii, I.V., and Gaivoronskaya, M.G., Age features of bone mineral density of lumbar vertebrae in adult men, Vestn. Voen. Med. Akad., 2015, vol. 49, no. 1, pp. 111–114.
Pigolkin, Yu.I., Yurchenko, M.A., Zolotenkova, G.V., et al., Assessment of the biological age of a man according to the radiographic features of the hand bones, Vestn. Sud. Med., 2015, no. 2, pp. 27–30.
Sveshnikov, A.A. and Ovchinnikov, E.N., Age-related changes in bone mineral density of the skeleton of men, Genii Ortop., 2010, no. 3, pp. 162–167.
Pfeiffer, S., Variability in osteon size in recent human populations, Am. J. Phys. Anthropol., 1998, vol. 106, no. 2, pp. 219–227.
Qiu, S., Fyhrie, D.P., Palnitkar, S., and Rao, D.S., Histomorphometric assessment of Haversian canal and osteocyte lacunae in different-sized osteons in human rib, Anat. Rec., 2003, vol. 272, no. 2, p. 520.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by P. Kuchina
Rights and permissions
About this article
Cite this article
Pigolkin, Y.I., Zolotenkova, G.V., Sereda, A.P. et al. Histometric Symptoms of Age-Sensitive Changes of Bone Tissue. Adv Gerontol 8, 320–327 (2018). https://doi.org/10.1134/S2079057018040124
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2079057018040124