Advances in Gerontology

, Volume 5, Issue 3, pp 176–179 | Cite as

Short peptides stimulate cell regeneration in skin during aging

  • N. I. Chalisova
  • N. S. Linkova
  • A. N. Zhekalov
  • A. O. Orlova
  • G. A. Ryzhak
  • V. Kh. Khavinson


The search for new safe and efficient low-molecular weight substances stimulating skin regeneration is an important objective of geriatric cosmetology. The present study addressed the effects of the peptides LK and AEDG at concentrations of 0.05–2.00 ng/mL on the proliferation of organotypic tissue cultures of skin from young and old animals. The application of peptides enhanced fibroblast proliferation in skin cell cultures from young and old animals by 29–45%. The effect on aging skin was observed in a narrower concentration range; in addition, it was less pronounced than the effect on skin cell cultures obtained from young animals. These data reveal the potential of LK and AEDG as components of cosmetic products that restore the structure of aging skin.


short peptides cell proliferation organotypic culture skin aging 


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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • N. I. Chalisova
    • 1
  • N. S. Linkova
    • 2
    • 3
  • A. N. Zhekalov
    • 1
  • A. O. Orlova
    • 2
  • G. A. Ryzhak
    • 2
  • V. Kh. Khavinson
    • 1
    • 2
    • 4
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia
  2. 2.St. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia
  3. 3.St. Petersburg State Polytechnical UniversitySt. PetersburgRussia
  4. 4.Mechnikov State Medical University of Northwestern RussiaSt. PetersburgRussia

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