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Study on nucleotide exchange and its interrelationship with prooxidant and antioxidant systems in humans of different ages

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Abstract

The interrelationship between purine nucleotide exchange and the antioxidant system in blood plasma and erythrocytes with respect to age, as well as the contribution of key enzymes of purine decomposition in the formation of derivatives of reactive oxygen metabolites, were studied. Fifty conditionally healthy individuals aged 40–79 years were examined. An age-related increase in all indicators of the blood plasma prooxidant system was found. In blood plasma, the statistically significant correlation of the studied parameters and age of the examined individuals, as well as the relationship between glutathione peroxidase and adenosine deaminase/xanthine oxidase, adenosine deaminase and xanthine oxidase were observed. A significant increase in the content of products of protein oxidative modification was found in plasma and erythrocytes during aging. A decrease in the activity of key antioxidant enzymes, superoxide dismutase, and glutathione peroxidase with age was observed in blood plasma and erythrocytes. The data obtained are indicative of an imbalance in the antioxidant system in blood plasma and erythrocytes, with age contributing to the development of pathological states as a result of increased oxidative stress, which is greatly manifested in aging.

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Authors and Affiliations

  1. Gorky Donetsk National Medical University, pr. Il’icha 16, Donetsk, 83003, Ukraine

    S. A. Zuikov

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Correspondence to S. A. Zuikov.

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Original Russian Text © S.A. Zuikov, 2014, published in Uspekhi Gerontologii, 2014, Vol. 27, No. 3, pp. 463–467.

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Zuikov, S.A. Study on nucleotide exchange and its interrelationship with prooxidant and antioxidant systems in humans of different ages. Adv Gerontol 5, 22–26 (2015). https://doi.org/10.1134/S2079057015010117

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  • DOI: https://doi.org/10.1134/S2079057015010117

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