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Influence of delta-sleep peptide on the enzymatic activity of the mitochondrial electron transport chain in various rat tissues with aging of the organism

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Abstract

It was shown that the subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) into rats aged 2–24 months with a dose of 100 μg/kg animal body weight in courses of 5 consecutive days per month has a stabilizing effect on NADH-dehydrogenase activity in the mitochondrial fractions of various tissues, which, together with the increasing capacity of the antioxidant system, should reduce the production of free radicals and their adverse action on cellular macromolecules; the succinate dehydrogenase activity did not change.

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Authors and Affiliations

  1. Southern Federal University, Rostov-on-Don, 344006, Russia

    T. I. Bondarenko & D. S. Kutilin

  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia

    I. I. Mihaleva

Authors
  1. T. I. Bondarenko
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  2. D. S. Kutilin
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  3. I. I. Mihaleva
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Corresponding author

Correspondence to T. I. Bondarenko.

Additional information

Original Russian Text © T.I. Bondarenko, D.S. Kutilin, I.I. Mihaleva, 2014, published in Uspekhi Gerontologii, 2014, Vol. 27, No. 3, pp. 496–502.

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Bondarenko, T.I., Kutilin, D.S. & Mihaleva, I.I. Influence of delta-sleep peptide on the enzymatic activity of the mitochondrial electron transport chain in various rat tissues with aging of the organism. Adv Gerontol 5, 6–11 (2015). https://doi.org/10.1134/S2079057015010038

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  • DOI: https://doi.org/10.1134/S2079057015010038

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