Peptide bioregulators: A new class of geroprotectors, report 2. The results of clinical trials

Abstract

This paper reviews the results of long-term studies by the authors on the clinical efficacy of peptide bioregulators (Timalin, Thymogen, Vilon, Epithalamin, Prostatilen, Cortexin, and Retinalamin) for the prevention of diseases and treatment of people of all ages. Particular attention is paid to analysis of the use of peptide bioregulators as geroprotectors.

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References

  1. 1.

    Al-Shukri, S.H., Gorbachev, A.G., and Kuz’min, I.V., The effect of Prostatilen on metabolic activity of phagocytes in patients with chronic pyelonephritis, Kazan. Med. Zh., 1996, no. 3, pp. 200–201.

    Google Scholar 

  2. 2.

    Al-Shukri, S.H., Gorbachev, A.G., Kuz’min, I.V., et al., Vvedenie v bioregulyatsionnuyu terapiyu pri urologicheskikh boleznyakh (Introduction to Bioregulating Therapy of Urologic Diseases), St. Petersburg: Nauka, 1996.

    Google Scholar 

  3. 3.

    Ashmarin, I.P., Small peptides in norm and pathology, Patol. Fiziol., 1982, no. 4, pp. 13–27.

    Google Scholar 

  4. 4.

    Boiko, I.N., Ivanov, K.S., Khavinson, V.Kh., et al., Role of immune-regulating therapy in complex treatment of patients with typhoid, in Immunokorrektsiya pri infektsionnoi patologii (Immune Correction Used in Infectious Pathology), Leningrad, 1988, pp. 11–12.

    Google Scholar 

  5. 5.

    Borisenko, K.K., Khilinskii, M.M., Malyshev, A.M., and Medvedeva, I.I., Implementation of Prostatilen for therapy of chronic prostatitis, Vestn. Dermatol., 1991, no. 8, pp. 47–50.

    Google Scholar 

  6. 6.

    Boyarova, S.K., Specific course and improvement of treatment of chronic general periodontitis in elderly and senile patients, Extended Abstract of Cand. Sci. (Med.) Dissertation, St. Petersburg, 2006.

    Google Scholar 

  7. 7.

    Vozianov, A.F., Gorpinchenko, I.I., Boiko, N.I., et al., Implementation of Prostatilen for treatment of patients with prostate diseases, Urol. Nefrol., 1991, no. 6, pp. 43–46.

    Google Scholar 

  8. 8.

    Gvozdeva, O.V. and Kuznik, B.I., Clinical implementation of Vilon for therapy of diffused toxic crop, Dal’nevost. Med. Zh., 2007, no. 2, pp. 123–125.

    Google Scholar 

  9. 9.

    Glaznikov, L.A., Buinov, L.G., Ryzhak, G.A., and Khavinson, V.Kh., Implementation of Cortexin for improvement of statokinetic stability of a man, Med. Akad. Zh., 2002, vol. 2, no. 3, pp. 91–98.

    Google Scholar 

  10. 10.

    Govorin, N.V., Implementation of Cortexin in therapy of Alzheimer’s disease, in Tsitomediny (Cytomedines), Chita, 1996, no. 2, pp. 38–39.

    Google Scholar 

  11. 11.

    Golovkin, V.I., Malinin, V.V., and Ryzhak, G.A., Gerontologicheskie aspekty bioregulyatsii terapii zabolevanii tsentral’noi nervnoi sistemy (Gerontological Aspects of Bioregulating Therapy of Central Nervous System Diseases), St. Petersburg: Foliant, 2000.

    Google Scholar 

  12. 12.

    Degtyarev, A.A., Zakharov, V.E., and Furgal, S.M., The experimental results of efficiency of immune regulators in antiepidemic practice, in Immunokorrektsiya pri infektsionnoi patologii (Immune Correction in Infectious Pathology), Leningrad, 1988, pp. 27–28.

    Google Scholar 

  13. 13.

    Dolgov, G.V., Tsvelev, Yu.V., and Malinin, V.V., Bioreguliruyushchaya terapiya v akusherstve i ginekologii (Bioregulating Therapy Applied in Obstetrics and Gynecology), St. Petersburg: Foliant, 2004.

    Google Scholar 

  14. 14.

    Zhits, M.Z., Mayun, L.B., and Belozertseva, N.P., Implementation of Thymalin for prophylactics of acute respiratory virus infection and chronic nonspecific pulmonary diseases in adults and children, in Immunokorrektsiya pri infektsionnoi patologii (Immune Correction in Infectious Pathology), Leningrad, 1988, pp. 31–33.

    Google Scholar 

  15. 15.

    Zhuk, E.A. and Galenok, V.A., Implementation of Thymogen for treatment of pancreatic diabetes, Ter. Arkh., 1996, no. 10, pp. 12–14.

    Google Scholar 

  16. 16.

    Iozefson, S.A., Implementation of Thymalin and Epytalaminum in prenatal period with prolonged pregnancy, in Mater. simp. “”Peptidnye bioregulyatory — tsitomediny” (Proc. Symp. “Peptide BioregulatorsCytomedines”), St. Petersburg, 1992, pp. 70–71.

    Google Scholar 

  17. 17.

    Korkushko, O.V., Khavinson, V.Kh., and Shatilo, V.B., Pineal’naya zheleza: puti korrektsii pri starenii (Pineal Gland: Correction of Ageing), St. Petersburg: Nauka, 2006.

    Google Scholar 

  18. 18.

    Korkushko, O.V., Khavinson, V.Kh., Butenko, G.M., and Shatilo, V.B., Peptidnye preparaty timusa i epifiza v profilaktike uskorennogo stareniya (Peptide Thymic and Epiphyseal Preparations Used in Prophylactic of Accelerated Aging), St. Petersburg: Nauka, 2002.

    Google Scholar 

  19. 19.

    Korkushko, O.V., Khavinson, V.Kh., Shatilo, V.B., et al., Diurnal rhythms of melatonin-forming function of epiphysis in elderly people, Usp. Gerontol., 2004, no. 15, p. 200.

    Google Scholar 

  20. 20.

    Korteksin — pyatiletnii opyt otechestvennoi nevrologii (Cortexin-5-Year Experience of National Neurology), Skoromtsa, A.A. and D’yakonova, M.M., Eds., St. Petersburg: Nauka, 2005.

    Google Scholar 

  21. 21.

    Kropotov, Yu.D., Chutko, L.S., Grin’-Yatsenko, V.A., et al., Implementation of peptide bioregulators for treatment of attention deterioration syndrome in children and adolescents, Med. Akad. Zh., 2002, vol. 2, no. 2, pp. 58–63.

    Google Scholar 

  22. 22.

    Kuznik, B.I., Morozov, V.G., and Khavinson, V.Kh., Tsitomediny (Cytomedines), St. Petersburg: Nauka, 1998.

    Google Scholar 

  23. 23.

    Kuznik, B.I., Pinelis, I.S., and Khavinson, V.Kh., Primenenie peptidnykh bioregulyatorov v stomatologii (Implementation of Peptide Bioregulators in Stomatology), St. Petersburg: Eskulap, 1999.

    Google Scholar 

  24. 24.

    Kuznik, B.I., Khavinson, V.Kh., Morozov, V.G., et al., Influence of thymalin on the curse of acute pneumonia in little children, Pediatriya, 1982, no. 4, pp. 22–25.

    Google Scholar 

  25. 25.

    Kuznik, B.I., Khavinson, V.Kh., Morozov, V.G., et al., Peptidnye bioregulyatory (Peptide Bioregulators), Moscow: Vuzovskaya Kniga, 2004.

    Google Scholar 

  26. 26.

    Kuznik, B.I., Isakova, N.V., Klyuchereva, N.N., et al., Influence of Vilon on immunity and hemostasis in different-age patients with pancreatic diabetes, Usp. Gerontol., 2007, vol. 20, no. 2, pp. 106–115.

    CAS  Google Scholar 

  27. 27.

    Maksimov, I.B. and Anisimova, G.V., Involyutsionnye tsentral’nye khorioretinal’nye distrofii: primenenie peptidnykh bioregulyatorov v kompleksnom lechenii (Involutionary Central Chorioretinal Dystrophy: Implementation of Peptide Bioregulators in Complex Therapy), St. Petersburg: Foliant, 2001.

    Google Scholar 

  28. 28.

    Maksimov, I.B., Moshetova, L.K., and Savost’yanova, S.A., Retinalamin v kompleksnom lechenii involyutsionnykh tsentral’nykh khorioretinal’nykh distrofii (Implementation of Retinalamin for Complex Therapy of Central Chorioretinal Dystrophies), St. Petersburg: Biont, 2006.

    Google Scholar 

  29. 29.

    Maksimov, I.B., Neroev, V.V., Khavinson, V.Kh., and Trofimova, S.V., Bioregulating therapy as a new direction in modern ophthalmology, Ross. Med. Vestn., 2003, no. 2, pp. 17–20.

    Google Scholar 

  30. 30.

    Morozov, V.G. and Khavinson, V.Kh., Peptidnye bioregulyatory (25-letniy opyt eksperimental’nogo i klinicheskogo izucheniya) (Peptide Bioregulators: 25-Year Experience and Clinical Study), St. Petersburg: Nauka, 1996.

    Google Scholar 

  31. 31.

    Morozov, V.G. and Khavinson, V.Kh., RF Patent 1218521, 1993.

  32. 32.

    Morozov, V.G. and Khavinson, V.Kh., US Patent 5070076, 1991.

  33. 33.

    Morozov, V.G. and Khavinson, V.Kh., US Patent 5538951, 1996.

  34. 34.

    Morozov, V.G., Khavinson, V.Kh., and Malinin, V.V., Peptidnye timomimetiki (Peptide Thymomimetics), St. Petersburg: Nauka, 2000.

    Google Scholar 

  35. 35.

    Morozov, V.G., Khavinson, V.Kh., Grechko, A.T., and Zhukov, V.V., RF Patent 1298979, 1993.

  36. 36.

    Morozov, V.G., Khavinson, V.Kh., Sidorova, N.D., Gorbachev, A.G., Isaeva, I.V., Chaika, O.V., and Konstantinov, V.L., RF Patent 1417244, 1993.

  37. 37.

    Morozov, V.G., Khavinson, V.Kh., Sidorova, N.D., Konstantinov, V.L., Chaika, O.V., and Govorova, N.F., RF Patent 1112606, 1994.

  38. 38.

    Morozov, V.G., Khavinson, V.Kh., Chaika, O.V., and Semenov, V.I., RF Patent 2104702, 1998.

  39. 39.

    Ovdenko, A.G., Malinin, V.V., and Spesivtsev, A.Yu., Clinical-immunological efficiency of Vilon for wounded with gunshot osteomyelitis of extremities, Tsytokin. Vosp., 2009, vol. 8, no. 2, pp. 22–28.

    Google Scholar 

  40. 40.

    Papava, K.M., Implementation of Cortexin in clinical therapy, Usp. Fiziol. Nauk, 1994, vol. 25, no. 4, p. 9.

    Google Scholar 

  41. 41.

    Pateyuk, V.G., Budazhabon, G.B., Kuznik, B.I., et al., Use of thymalin in therapy of erysipelas patients, Klin. Med., 1987, no. 7, pp. 110–113.

    Google Scholar 

  42. 42.

    Pinelis, Yu.I., Malezhik, L.P., and Malezhik, M.S., Adaptive possibilities of protective systems of organism at chronic general periodontitis in elderly people, Akad. Zh. Zap. Sib., 2011, no. 2, pp. 36–37.

    Google Scholar 

  43. 43.

    Rapoport, Zh.Zh. and Mayun, L.B., Immunity disbalance at bronchial asthma in children, in Immunodefitsity i allergiya (Immune Deficiency and Allergy), Moscow, 1996, pp. 251–253.

    Google Scholar 

  44. 44.

    Rozenberg, V.A., Korsakov, S.V., Kuznik, B.I., and Kustovskaya, E.M., Implementation of Vilon in oncology therapy of elderly patients with inoperable cancer types, Dal’nevost. Med. Zh., 2008, no. 1, pp. 80–82.

    Google Scholar 

  45. 45.

    Rybnikov, V.Yu. and Zakutskii, N.G., Peptidnaya regulyatsiya funktsii mozga (Peptide Regulation of Brain Functions), St. Petersburg: Foliant, 2000.

    Google Scholar 

  46. 46.

    Ryzhak, G.A., Alekhova, T.M., and Bakhidze, E.V., Efficiency of implementation of peptide bioregulator in surgery, in II Ross. simp. po khimii i biologii peptidov, S.-Peterb., 25–27 maya 2005 g., Tezisy dokladov (II Russ. Symp. on Chemistry and Biology of Peptides, St. Petersburg, May 25–27, 2005, Abstracts of Papers), p. 106.

  47. 47.

    Ryzhak, G.A., Malinin, V.V., and Platonova, V.N., Korteksin i regulyatsiya funktsii golovnogo mozga (Cortexin and Regulation of Brain Functions), St. Petersburg: Foliant, 2003.

    Google Scholar 

  48. 48.

    Stakhovskaya, L.V., Meshkova, K.S., Dadasheva, M.N., et al., Multicentre random prospective double blind placebo-controlled study of safety and efficiency of Cortexin in acute and early recovery period of hemispheric ischemic stroke, Vestn. Voen.-Med. Akad., 2012, no. 1 (37), pp. 238–244.

    Google Scholar 

  49. 49.

    Tkachuk, V.N., Gorbachev, A.G., and Khavinson, V.Kh., Implementation of Prostatilen in therapy of patients with chronic prostatitis, Urol. Nefrol., 1991, no. 6, pp. 40–43.

    Google Scholar 

  50. 50.

    Trofimova, S.V., Influence of bioregulators on elderly and senile people with diabetic retinopathy, Usp. Gerontol., 2000, no. 2, pp. 119–121.

    Google Scholar 

  51. 51.

    Trofimova, S.V. and Fikhman, O.Z., Bioreguliruyushchaya terapiya i kachestvo zhizni lyudei starshego pokoleniya s narusheniem funktsii zreniya (Bioregulating Therapy and Life Quality of Elderly People with Vision Diseases), St. Petersburg: Falcon Crest, 2008.

    Google Scholar 

  52. 52.

    Trofimova, S.V. and Khavinson, V.Kh., Efficiency of bioregulators in therapy of diabetic retinopathy, Vestn. Oftal’mol., 2001, no. 3, pp. 54–57.

    Google Scholar 

  53. 53.

    Khavinson, V.Kh., Thymalin as a regulator of homeostasis, in Rol’ peptidnykh bioregulyatorov (tsitomedinov) v regulyatsii gomeostaza (Role of Peptide Bioregulators (Cytomedines) in Regulation of Homeostasis), Leningrad, 1987, pp. 99–100.

    Google Scholar 

  54. 54.

    Khavinson, V.Kh. and Anisimov, V.N., Peptidnye bioregulyatory i starenie (Peptide Bioregulators and Aging), St. Petersburg: Nauka, 2003.

    Google Scholar 

  55. 55.

    Khavinson, V.Kh. and Morozov, V.G., Experimental and clinical study of new immune-regulating preparation-thymalin, Voen.-Med. Zh., 1982, no. 5, pp. 37–39.

    Google Scholar 

  56. 56.

    Khavinson, V.Kh. and Morozov, V.G., Peptidy epifiza i timusa v regulyatsii stareniya (Role of Peptides of Epiphysis and Thymus in Correction of Aging), St. Petersburg: Foliant, 2001.

    Google Scholar 

  57. 57.

    Khavinson, V.Kh. and Ryzhak, G.A., Peptide bioregulator-thymalin, Farmakoter. Alm., 2009, no. 2, pp. 45–64.

    Google Scholar 

  58. 58.

    Khavinson, V.Kh. and Trofimova, S.V., Peptidnye bioregulyatory v oftal’mologii (Peptide Bioregulators in Ophthalmology), St. Petersburg: Foliant, 2000.

    Google Scholar 

  59. 59.

    Khavinson, V.Kh. and Trofimova, S.V., Bioregulating therapy as a new direction in therapy of diabetic retinopathy, Mezhd. Med. Zh., 2001, no. 2, pp. 91–93.

    Google Scholar 

  60. 60.

    Khavinson, V.Kh. and Shutak, T.S., Primenenie Epitalamina pri insulinnezavisimom sakharnom diabete (Implementation of Epithalamin for Therapy of Insulin-Independent Pancreatic Diabetics), St. Petersburg: Foliant, 2000.

    Google Scholar 

  61. 61.

    Khavinson, V.Kh., Danilichev, V.F., and Vasil’eva, L.A., Remote results of implementation of Retinalamin for therapy of pigment peripheral abiotrophy of retina (PPAR), in Aktual’nye problemy geriatrii (Relevant Problems of Geriatrics), St. Petersburg: S.-Peterb. Med. Akad. Posledipl. Obraz., 2001, pp. 232–234.

    Google Scholar 

  62. 62.

    Khavinson, V.Kh., Kuznik, B.I., and Ryzhak, G.A., Peptide bioregulators is a new class of geroprotectors. Message 1. Experimental results, Usp. Gerontol., 2012, vol. 25, no. 4, pp. 696–708.

    Google Scholar 

  63. 63.

    Khavinson, V.Kh., Malinin, V.V., and Ryzhak, G.A., RF Patent 2302871, 2007.

  64. 64.

    Khavinson, V.Kh., Malinin, V.V., and Ryzhak, G.A., RF Patent 2302870, 2007.

  65. 65.

    Khavinson, V.Kh., Seryi, S.V., and Malinin, V.V., RF Patent 080120, 1997.

  66. 66.

    Khavinson, V.Kh., Sinakevich, N.V., and Seryi, S.V., Timogen (Thymogen), St. Petersburg: Tipogr. Profsoyuz., 1991.

    Google Scholar 

  67. 67.

    Khavinson, V.Kh., Khokkanen, V.M., and Trofimova, S.V., Peptidnye bioregulyatory v lechenii diabeticheskoi retinopatii (Use of Peptide Bioregulators for Therapy of Diabetic Retinopathy), St. Petersburg: Foliant, 1999.

    Google Scholar 

  68. 68.

    Khavinson, V.Kh., Morozov, V.G., Sidorova, N.D., Miranovich, Yu.A., Maslakov, O.A., Konstantinov, V.L., and Chaika, O.V., RF Patent 1436305, 1993.

  69. 69.

    Khavinson, V.Kh., Morozov, V.G., Sidorova, N.D., Konstantinov, V.L., Chaika, O.V., and Inanova, V.A., RF Patent 944191, 1993.

  70. 70.

    Khavinson, V.Kh., Seryi, S.V., Kozhemyakin, A.L., and Valeev, R.I., RF Patent 2058780, 1996.

  71. 71.

    Khavinson, V.Kh., Seryi, S.V., Kozhemyakin, A.L., and Valeev, R.I., RF Patent 2073518, 1997.

  72. 72.

    Khavinson, V.Kh., Morozov, V.G., Seryi, S.V., and Malinin, V.V., RF Patent 2139085, 1998.

  73. 73.

    Khavinson, V.Kh., Morozov, V.G., Semenova, V.I., Chaika, O.V., and Ryzhak, G.A., RF Patent 2163129, 2001.

  74. 74.

    Kharintseva, S.V., Dynamics of visual functions in distant period in patients with exudative hemorrhagic pathologies of retina after implementation of Retinalamin and Cortexin, Kuban. Nauchn. Med. Vestn., 2009, no. 7 (112), pp. 76–80.

    Google Scholar 

  75. 75.

    Kharintseva, S.V., Implementation of Retinalamin in complex therapy of central edema at diabetic retinopathy, Vestn. Mezhd. Akad. Nauk Ekol. Bezop. Zhiznedeyat., 2009, vol. 11, no. 5, pp. 61–65.

    Google Scholar 

  76. 76.

    Kharintseva, S.V., Retina-protective therapy of diabetic central edema in elderly people, Usp. Gerontol., 2011, vol. 24, no. 3, pp. 521–523.

    CAS  Google Scholar 

  77. 77.

    Khudzik, L.B., Morozova, T.I., and Rebrov, A.P., Efficiency of immune corrigent therapy by cytomedines at infiltrate lung tuberculosis, Kazan. Med. Zh., 1994, no. 6, pp. 412–417.

    Google Scholar 

  78. 78.

    Chazov, E.I., Protective systems of organism as the basis for search and development of new orginal medicines, Vestn. Ross. Akad. Med. Nauk, 2012, no. 5, pp. 6–7.

    Google Scholar 

  79. 79.

    Shustov, S.B., Khavinson, V.Kh., Shutak, T.S., et al., Influence of Epithalamin on carbohydrate metabolism and cardiovascular system in insulin-dependent patients with pancreatic diabetics, Klin. Med., 1998, no. 9, pp. 45–48.

    Google Scholar 

  80. 80.

    Yushkova, T.A. and Yushkov, V.V., Correction of dysfunction of immune system by Thymogen at immunobiological incompatibility of spouses, in Mater. mezhd. simp. “Gerontologicheskie aspekty peptidnoi regulyatsii funktsii organizma” (Proc. Int. Symp. “Gerontological Aspects of Peptide Regulation of Functions of Organism”), St. Petersburg: Nauka, 1996, pp. 100–101.

    Google Scholar 

  81. 81.

    Yakovlev, G.M., Morozov, V.G., Khavinson, V.Kh., Deigin, V.I., and Korotkov, A.M., RF Patent 1582393, 1990.

  82. 82.

    Yas’kevich, L.S., Krutilina, N.I., Kostetskaya, T.V., et al., Implementation of peptide bioregulator in complex therapy of oncologic diseases of elderly patients, Usp. Gerontol., 2005, no. 16, pp. 97–100.

    Google Scholar 

  83. 83.

    Khavinson, V.Kh., Peptides and ageing, Neuroendocr. Lett., 2002, vol. 23,suppl. 3, p. 144.

    Google Scholar 

  84. 84.

    Khavinson, V.Kh. and Malinin, V.V., Gerontological Aspects of Genome Peptide Regulation, Karger, 2005.

    Google Scholar 

  85. 85.

    Trofimova, S.V. and Khavinson, V.Kh., Effect of Retinalamin and Cortexin on the development of age-related macular degeneration, in 17th World Congr. Int. Assoc. Gerontol., Vancouver, Canada, 2001, vol. 47, suppl. 1, pp. 430–431.

    Google Scholar 

  86. 86.

    Trofimova, S. and Khavinson, V.Kh., Application of Retinalamin in exudative age-related macular degeneration, in 4th Int. Symp. “Ocular Pharmacology and Pharmaceutics-ISOPP,” Seville, Spain, February 28th–March 3, 2002, Abstracts of Papers, 2002, p. 7.

    Google Scholar 

  87. 87.

    Trofimova, S.V. and Khavinson, V.Kh., Peptide bioregulators: a new approach for treating diabetic retinopathy, Acta Ophthalmol. Scand., 2002, vol. 80, no. 4, p. 452.

    Google Scholar 

  88. 88.

    Vitkovsky, Y., Kuznik, B., Solpov, A., and Magen, E., Status of platelet-lymphocyte aggregation in circulating blood of patients type 1 diabetes with and without diabetic nephropathy, Isr. Med. Assoc. J., 2008, no. 10, pp. 691–694.

    Google Scholar 

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Original Russian Text © V.Kh. Khavinson, B.I. Kuznik, G.A. Ryzhak, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 1, pp. 20–37.

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Khavinson, V.K., Kuznik, B.I. & Ryzhak, G.A. Peptide bioregulators: A new class of geroprotectors, report 2. The results of clinical trials. Adv Gerontol 4, 346–361 (2014). https://doi.org/10.1134/S2079057014040122

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Keywords

  • peptide bioregulators
  • geroprotectors
  • age-related pathology
  • aging