Skip to main content
SpringerLink
Log in

Age-related changes in the hypothalamic-pituitary-adrenal axis: Experimental studies in primates

Advances in Gerontology volume 4, pages 269–273 (2014)Cite this article

Abstract

This review summarizes the results of the author’s works dedicated to age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in primates during aging under basal conditions, including disturbances of circadian rhythms, and under conditions of its inhibition and activation by specific stimuli. In addition, this article presents original data on the age-related peculiarities of the HPA axis functioning under acute psycho-emotional stress taking into account the time of day and individual features of adaptive behavior of animals, severe chronic stress caused by hemoblastosis, and repeated mild psycho-emotional stress. Age disturbances in functioning of the HPA axis are of pathophysiological significance for the development of stress- and age-related pathologies and progression of aging. Individuals with depressive behavior are the most vulnerable to stress and pathological aging.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Goncharova, N.D., Hormonal function of human and monkey adrenal gland at hemoblastosis and aging, Byul. Eksp. Biol., 1997, vol. 124, no. 8, pp. 207–210.

    CAS  Google Scholar 

  2. Goncharova, N.D. and Lapin, B.A., Adrenal androgens: age peculiarities of synthesis and regulation of production in a man and monkeys, Vestn. Ross. Akad. Med. Nauk, 2005, no. 8, pp. 44–50.

    Google Scholar 

  3. Goncharova, N.D., Vengerin, A.A., and Chigarova, O.A., Recurring moderate stress stimulates the production of dehydroepiandrosterone sulfate (DHEAS) and softening corticosteroid disbalance in old rhesus monkey, Byul. Eksp. Biol., 2012, vol. 153, no. 5, pp. 712–716.

    Google Scholar 

  4. Goncharova, N.D., Lapin, B.A., and Khavinson, V.Kh., Age-related disbalance of endocrine functions and their possible correction, Byul. Eksp. Biol., 2002, vol. 134, no. 11, pp. 484–489.

    Google Scholar 

  5. Goncharova, N.D., Oganyan, T.E., and Smelkova, S.A., Influence of aging on stress-reactivity of adrenal cortex in laboratory primates. Diurnal dependence, Byul. Eksp. Biol., 2006, vol. 141, no. 3, pp. 345–348.

    Google Scholar 

  6. Goncharova, N.D., Khavinson, V.Kh., and Lapin, B.A., Pineal’naya zheleza i vozrastnaya patologiya (maekhanizmy i korrektsiya) (Pineal Gland and Age Pathology (Mechanisms and Correction)), St. Petersburg: Nauka, 2007.

    Google Scholar 

  7. Katsiya, G.V., Goncharova, N.D., and Goncharov, N.P., Hormonal function of sexual and adrenal glands in aging, in Vsesoyuzn. konf. “Mekhanizmy stareniya i dolgoletiya,” Tezisy dokladov (All-Union Conf. “Mechanisms of Aging and Longevity,” Abstracts of Papers), Sukhumi, 1986, pp. 89–90.

    Google Scholar 

  8. Korkushko, O.V., Goncharova, N.D., Shatilo, V.B., et al., Correction of disbalance of diurnal rhythm of melatonin-synthesizing function of epiphysis in old monkeys and humans, Zh. Akad. Med. Navuk Ukr., 2007, vol. 13, no. 2, pp. 275–290.

    CAS  Google Scholar 

  9. Bicikova, M., Tallova, J., Hill, M., et al., Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder, Neurochem. Res., 2000, vol. 25, no. 12, pp. 1623–1627.

    Article  CAS  PubMed  Google Scholar 

  10. Deuster, P.A., Faraday, M.M., Chrousos, G.P., and Poth, M.A., Effects of dehydroepiandrosterone and alprazolam on hypothalamic-pituitary responses to exercise, J. Clin. Endocrinol. Metab., 2005, vol. 90, pp. 4777–4783.

    Article  CAS  PubMed  Google Scholar 

  11. Ekmekcioglu, C., Melatonin receptors in humans: biological role and clinical relevance, Biomed. Pharmacother., 2006, vol. 60, pp. 97–108.

    Article  CAS  PubMed  Google Scholar 

  12. Ferrari, E. and Magri, F., Role of neuroendocrine pathways in cognitive decline during aging, Ageing Res. Rev., 2008, vol. 7, pp. 225–233.

    Article  CAS  PubMed  Google Scholar 

  13. Gilpin, H., Whitcomb, D., and Cho, K., Atypical evening cortisol profile induces visual recognition memory deficit in healthy human subjects, Mol. Brain, 2008, vol. 1, art. 4. doi: 10.1186/1756-6606-1-4

  14. Goncharova, N.D., Hypothalamic-pituitary-adrenal axis and antioxidant enzymes: circadian rhythms, stress, and aging, Front. Neuroendocrinol., 2006, vol. 27, pp. 52–53.

    Article  Google Scholar 

  15. Goncharova, N.D., The hypothalamic-pituitary-adrenal axis in nonhuman primates: circadian rhythms of stress responsiveness and aging, in Primatology: Theories, Methods and Research, New York: Nova Sci., 2009, pp. 29–52.

    Google Scholar 

  16. Goncharova, N.D., Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation, Front. Endocrinol. (Lausanne), 2013, vol. 4, art. 26. doi: 10.3389/fendo.2013.00026

  17. Goncharova, N.D. and Lapin, B.A., Effects of aging on the hypothalamic-pituitary-adrenal system function in non-human primates, Mech. Ageing Dev., 2002, vol. 123, pp. 1191–1201.

    Article  CAS  PubMed  Google Scholar 

  18. Goncharova, N.D., Marenin, V.Y., and Oganyan, T.E., Aging of the hypothalamic-pituitary-adrenal axis in nonhuman primates with depression-like and aggressive behavior, Aging, 2010, vol. 2, pp. 854–866.

    CAS  PubMed Central  PubMed  Google Scholar 

  19. Goncharova, N.D., Marenin, V.Y., and Vengerin, A.A., Age-related changes in the reliability of antioxidant enzyme defense in monkeys with different types of adaptive behavior, Curr. Aging Sci., 2013, vol. 6, no. 2, pp. 163–169.

    Article  CAS  PubMed  Google Scholar 

  20. Goncharova, N.D., Vengerin, A.A., Khavinson, V.Kh., and Lapin, B.A., Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas, Exp. Gerontol., 2005, vol. 40, pp. 51–57.

    Article  CAS  PubMed  Google Scholar 

  21. Goncharova, N.D., Shmaliy, A.V., Marenin, V.Y., et al., Circadian and age-related changes in stress responsiveness of the adrenal cortex and erythrocyte antioxidant enzymes in female rhesus monkeys, J. Med. Primatol., 2008, vol. 37, pp. 229–238.

    Article  PubMed  Google Scholar 

  22. Kalsbeek, A., Fliers, E., Hofman, M.A., et al., Vasopressin and the output of the hypothalamic biological clock, J. Neuroendocrinol., 2010, vol. 22, pp. 362–372.

    Article  CAS  PubMed  Google Scholar 

  23. Maninger, N., Capitanio, J.P., Mason, W.A., et al., Acute and chronic stress increase DHEAS concentrations in rhesus monkeys, Psychoneuroendocrinology, 2010, vol. 35, pp. 1055–1062.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Maninger, N., Wolkowitz, O.M., Reus, V.I., et al., Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), Front. Neuroendocrinol., 2009, vol. 30, pp. 65–91.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Mellon, S.H. and Vaudry, H., Biosynthesis of neurosteroids and regulation of their synthesis, Int. Rev. Neurobiol., 2001, vol. 46, pp. 33–78.

    Article  CAS  PubMed  Google Scholar 

  26. Nagendra, R.P., Maruthai, N., and Kutty, B.M., Meditation and its regulatory role on sleep, Front. Neurol., 2012, vol. 3, art. 54. doi: 10.3389/fneur.2012.00054

  27. Scullin, C.S. and Partridge, L.D., Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit, Hippocampus, 2012, vol. 22, no. 11, pp. 2184–2198.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Veseloye 1, Adler, Sochi, 354376, Russia

    N. D. Goncharova

  2. Sochi State University, ul. Sovetskaya 26-A, Sochi, 354000, Russia

    N. D. Goncharova

Authors
  1. N. D. Goncharova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. D. Goncharova.

Additional information

Original Russian Text © N.D. Goncharova, 2014, published in Uspekhi Gerontologii, 2014, Vol. 27, No. 2, pp. 269–274.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Goncharova, N.D. Age-related changes in the hypothalamic-pituitary-adrenal axis: Experimental studies in primates. Adv Gerontol 4, 269–273 (2014). https://doi.org/10.1134/S2079057014040109

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079057014040109

Keywords

search

Navigation