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Age-related changes in the hypothalamic-pituitary-adrenal axis: Experimental studies in primates


This review summarizes the results of the author’s works dedicated to age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in primates during aging under basal conditions, including disturbances of circadian rhythms, and under conditions of its inhibition and activation by specific stimuli. In addition, this article presents original data on the age-related peculiarities of the HPA axis functioning under acute psycho-emotional stress taking into account the time of day and individual features of adaptive behavior of animals, severe chronic stress caused by hemoblastosis, and repeated mild psycho-emotional stress. Age disturbances in functioning of the HPA axis are of pathophysiological significance for the development of stress- and age-related pathologies and progression of aging. Individuals with depressive behavior are the most vulnerable to stress and pathological aging.

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Correspondence to N. D. Goncharova.

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Original Russian Text © N.D. Goncharova, 2014, published in Uspekhi Gerontologii, 2014, Vol. 27, No. 2, pp. 269–274.

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Goncharova, N.D. Age-related changes in the hypothalamic-pituitary-adrenal axis: Experimental studies in primates. Adv Gerontol 4, 269–273 (2014).

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