On the change in the isotope compositions of living organisms during aging and evolution


This article notes that changes in the isotope composition of living organisms during aging and in evolution was predicted on the basis of the “principle of the stability of matter.” This principle was formulated by the author in the late 1970s. New quantitative estimates were made that confirm this prediction. To date there are many studies that have confirmed the previously formulated thesis of the author. These facts provide a new confirmation of the thermodynamic theory of the origin of life, its evolution, and the aging of living organisms.

This is a preview of subscription content, access via your institution.


  1. 1.

    Gladyshev, G.P., Supramolekulyarnaya termodinamika — klyuch k osoznaiyu yavleniya zhizni (Supramolecular Thermodynamics as a Key to Perception of Life Phenomenon), Moscow, 2003.

    Google Scholar 

  2. 2.

    Gladyshev, G.P., Thermodynamic theory of evolution and aging, Usp. Gerontol., 2012, vol. 25, no. 3, pp. 373–385.

    CAS  Google Scholar 

  3. 3.

    Gladyshev, G.P., Collection of articles. http://gladyshevevolution.wordpress.com/; http://endeav.net/news.html

  4. 4.

    Ignatov, I. and Mosin, O.V., Isotope composition of water and longevity, Naukovedenie, 2013, no. 1. http://naukovedenie.ru/PDF/41tvn113.pdf, 2012. http://www.pressmk.ru/news/detail.php?ID=313

    Google Scholar 

  5. 5.

    Sychev, V.V., Slozhnye termodinamicheskie sistemy (Complex Thermodynamic System), Moscow: MEI, 2009.

    Google Scholar 

  6. 6.

    Gladyshev, G.P., On the thermodynamics of biological evolution, J. Theor. Biol., 1978, vol. 75, no. 4, pp. 425–441.

    CAS  PubMed  Article  Google Scholar 

  7. 7.

    Gladyshev, G.P., Thermodynamic Theory of the Evolution of Living Beings, New York: Nova Sci. Publ., 1997.

    Google Scholar 

  8. 8.

    Gladyshev, G.P., The principle of substance stability is applicable to all levels of organization of living matter, Int. J. Mol. Sci., 2006, no. 7, pp. 98–110. http://www.mdpi.org/ijms/papers/i7030098.pdf

    Google Scholar 

  9. 9.

    Gladyshev, G.P. and Ershov, Yu.A., Principles of the thermodynamics of biological systems, J. Theor. Biol., 1982, vol. 94, no. 2, pp. 301–343.

    CAS  PubMed  Article  Google Scholar 

  10. 10.

    Sterner, R.W. and Elser, J.J., Ecological Stoichiometry: The Biology of Elements from Molecules to the Biosphere, Princeton: Princeton Univ. Press, 2002.

    Google Scholar 

  11. 11.

    Thims, L., Molecular evolution table, EoHT*. http://www.eoht.info/page/Molecular+evolution+table

Download references

Author information



Corresponding author

Correspondence to G. P. Gladyshev.

Additional information

Original Russian Text © G.P. Gladyshev, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 3, pp. 417–418.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gladyshev, G.P. On the change in the isotope compositions of living organisms during aging and evolution. Adv Gerontol 4, 107–108 (2014). https://doi.org/10.1134/S2079057014020052

Download citation


  • life
  • isotopes
  • principle of substance stability
  • aging
  • thermodynamics
  • evolution