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The effect of intracerebral transplantation of mesenchymal stem cells on orientation and exploratory behavior of aged animals

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Abstract

Male Wistar-Kyoto rats (12 and 22–24 months old) were intracerebrally transplanted with syngeneic mesenchymal stem cells (MSCs). Then, the orientation and exploratory behavior of these animals at the age of 2 years (i.e., 1 year or 3 weeks after MSC transplantation) was assessed in an “open field” test. The basic behavioral acts of the older rats (22–24 months old) were inhibited compared to the younger animals (2–3 months old). The transplantation of MSCs did not improve the orientation and exploratory behavior of old rats. The results of morphological and immunohistochemical analysis suggest that the intracerebral MSC transplantation led to partial injury of the ipsilateral hemisphere cortex.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    I. B. Sokolova, I. V. Sergeev & D. P. Dvoretsky

  2. Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akad. Pavlova 12, St. Petersburg, 197376, Russia

    O. R. Fedotova & E. G. Gilerovich

  3. Almazov Federal Center for Heart, Blood, and Endocrinology, ul. Akkuratova 2, St. Petersburg, 197341, Russia

    S. V. Anisimov & M. V. Puzanov

Authors
  1. I. B. Sokolova
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  2. O. R. Fedotova
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  3. E. G. Gilerovich
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  4. I. V. Sergeev
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  5. S. V. Anisimov
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  6. M. V. Puzanov
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  7. D. P. Dvoretsky
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Corresponding author

Correspondence to I. B. Sokolova.

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Original Russian Text © I.B. Sokolova, O.R. Fedotova, E.G. Gilerovich, I.V. Sergeev, S.V. Anisimov, M.V. Puzanov, D.P. Dvoretsky, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 2, pp. 236–241.

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Sokolova, I.B., Fedotova, O.R., Gilerovich, E.G. et al. The effect of intracerebral transplantation of mesenchymal stem cells on orientation and exploratory behavior of aged animals. Adv Gerontol 4, 22–27 (2014). https://doi.org/10.1134/S2079057014010111

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  • DOI: https://doi.org/10.1134/S2079057014010111

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