Abstract
This article presents the results of a study of the dynamics of the health state of patients of different age and sex, suffering simultaneously from several non-serious diseases, in the process of their treatment under stationary hospital conditions and the results of the determination of their biological age before and after the course of treatment. The study has revealed distinct differences in the number of diseases, their character, the length of treatment and its success, depending on age and sex. However, in those over 60, these differences gradually disappear. A multiple, though non-serious, pathology negatively influences the indicators of biological age for men of a calendar age of 20–39 years and women of a calendar age of 20–39 and over 60, but the gero-protective effect of treatment is very low. In a number of cases in the treatment process for multiple pathology, it is found even to increase in indicators of originally lower biological age and their approximation to indicators of the calendar age. We explain this result both as disturbances of adaptation of the organism to the non-serious disease in the process of the given treatment and as a pathological phenomenon similar to the considerably higher biological age.
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References
Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Aging), 2 vols., Sankt-Petersburg: Nauka, 2008.
Anisimov, V.N. and Vinogradova, I.A., Starenie zhenskoi reproduktivnoi sistemy i melatonin (Aging of Female Reproductive System and Melatonin), St. Petersburg: Sistema, 2008.
Ar’eva, G.T., Sovetkina, N.V., Ovsyannikova, N.A., and Ar’ev, A.L., Comorbid and multimorbid conditions in geriatrics (a review), Usp. Gerontol., 2011, vol. 24, no. 4, pp. 612–619.
Borovkova, T.A. and Myakotnykh, V.S., Current problems in mutual relations of cerebral vascular and cardiovascular diseases in elderly and senile age, Usp. Gerontol., 2010, vol. 23, no. 3, pp. 409–420.
Dontsov, V.I., Krut’ko, V.N., and Podkolzin, A.A., Fundamental’nye mekhanizmy geroprofilaktiki (Fundamental Mechanisms of Geroprophylactic), Moscow: Bioinformservis, 2002.
Dontsov, V.I., Trukhanov, A.I., and Krut’ko, V.N., Meditsina antistareniya: fundamental’nye osnovy (Medicine of Antiaging: Fundamental Principles), Moscow: URSS, 2010.
Zhuravleva, T.P., Osnovy geriatrii (Principles of Geriatrics), Moscow: Forum Infra, 2007.
Zakharov, V.V., All-Russian program of epidemiological studies and therapy of cognitive disorders in elderly age “Prometei”, Nevrol. Zh., 2006, no. 11, pp. 27–32.
Kravtsova, E.Yu. and Martynova, G.A., Peculiarities of clinical course and the result of a ischemia of active-age people, Vestn. Voen.-Med. Akad., 2007, no. 1 (170), pp. 234–235.
Lazebnik, L.B., Konev, Yu.V., and Efremov, L.I., Polymorbidity in geriatric practice: quantitative and qualitative assessment, Klin. Gerontol., 2012, nos. 1–2, pp. 36–42.
Myakotnykh, V.S., Yampolskaya, V.V., Samoilova, V.N., et al., Accelerated senescence of armed conflicts participants suffering from the consequences of war cranial-cerebral trauma and alcoholism, Usp. Gerontol., 2007, vol. 20, no. 1, pp. 112–117.
Safarova, G.L., Demography of aging: current state and priority-driven research directions, Usp. Gerontol., 2009, vol. 22, no. 1, pp. 49–59.
Yunkerov, V.I. and Grigor’ev, S.G., Matematiko-statisticheskaya obrabotka dannykh meditsinskikh issledovanii (Mathematical and Statistical Delivery of the Data of Medical Investigations), St. Petersburg: Voen.-Med. Akad., 2005.
Yastrebov, A.P. and Meshchaninov, V.N., Starenie, perekisnoe okislenie lipidov i biovozrast (Aging, Peroxidation of Lipids, and Biological Age), Yekaterinburg: Ural. Sledopyt, 2005.
Carlson, M.C., Fried, L.P., Xue, Q.L., et al., Validation of the Hopkins medication schedule to identify difficulties in taking medications, J. Gerontol., Ser. A, 2005, vol. 60, no. 2, pp. 217–223.
DiCarlo, A., Baldereschi, M., Amaducci, L., et al., Cognitive impairment without dementia in older people: prevalence, vascular risk factors, impact on disability. The Italian longitudinal study on aging, J. Am. Geriat. Soc., 2000, vol. 48, pp. 775–782.
Goudochnikov, V.I., Comparison of age-related dynamics and gender differences in morbidity and mortality caused by several groups of diseases: no evidence for unique general scheme of aging potentially modifiable by perinatal programming, J. Dev. Origins Health Dis., 2009, vol. 1,suppl. 1, pp. 123–128.
World Health Organization, International society of hypertension: guidelines for the management of hypertension, J. Hypertens., 1999, vol. 17, pp. 151–183.
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Original Russian Text © V.S. Myakotnykh, I.V. Gavrilov, K.V. Egorin, V.N. Meshchaninov, T.A. Borovkova, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 2, pp. 347–354.
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Myakotnykh, V.S., Gavrilov, I.V., Egorin, K.V. et al. The dynamics of health and the rate of aging in patients of different age and sex in the treatment of moderate multiple pathologies. Adv Gerontol 4, 55–61 (2014). https://doi.org/10.1134/S207905701401007X
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DOI: https://doi.org/10.1134/S207905701401007X