Abstract
Age-related changes in the microviscosity coefficient and polarity in the zones of lipid-lipid and lipid-protein contacts have been studied in erythrocyte membranes of 4- and 12-month-old rats (group 1, n = 20, and group 2, n = 20, respectively) using the pyrene lateral diffusion method. Each group included ten control animals and ten animals in which post-infarction cardiac remodeling had been induced. Increased microviscosity and polarity of annular and total membrane lipids were detected in erythrocyte membranes of 12-month-old animals. A pronounced increase in the microviscosity and polarity of erythrocyte membranes in the zone of annular and total lipids occurred in 4-month-old animals in which PICS was induced. Decreased microviscosity in the lipid bilayer and increased microviscosity in the annular lipid zone was characteristic of 12-month-old animals suffering from PICS; lipid polarity in this group was high and did not change.
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Original Russian Text © T.Yu. Rebrova, S.A. Afanas’ev, O.D. Putrova, S.V. Popov, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 4, pp. 644–647.
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Rebrova, T.Y., Afanas’ev, S.A., Putrova, O.D. et al. Age-related characteristics of erythrocyte membrane microviscosity in experimental cardiosclerosis. Adv Gerontol 3, 211–214 (2013). https://doi.org/10.1134/S2079057013030119
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DOI: https://doi.org/10.1134/S2079057013030119