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Tetrapeptide stimulates functional activity of pancreatic cells in aging

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Abstract

In this study, the molecular mechanisms of pancreoprotective action of the tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging human pancreatic cells have been investigated. It has been established that the tetrapeptide under study increases the expression of matrix metallopreteinases MMP2 and MMP9, serotonin, glycoprotein CD79α, antiapoptotic protein Mcl-1, and proliferation markers PCNA and Ki67, as well as decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures. Thus, the clinical effect of the tetrapeptide observed in elderly patients with type-2 diabetes mellitus and pancreatitis may be due to its ability to activate the expression of signaling molecules, i.e., markers of functional activity of pancreatic cells.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    V. Kh. Khavinson

  2. St. Petersburg Institute of Bioregulation and Gerontology, pr. Dinamo 3, St. Petersburg, 197110, Russia

    V. Kh. Khavinson, N. N. Sevostyanova, A. O. Durnova, N. S. Linkova, S. I. Tarnovskaya, A. V. Dudkov & T. V. Kvetnaya

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  1. V. Kh. Khavinson
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  2. N. N. Sevostyanova
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  3. A. O. Durnova
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  4. N. S. Linkova
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  5. S. I. Tarnovskaya
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  6. A. V. Dudkov
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  7. T. V. Kvetnaya
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Correspondence to V. Kh. Khavinson.

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Original Russian Text © V.Kh. Khavinson, N.N. Sevostyanova, A.O. Durnova, N.S. Linkova, S.I. Tarnovskaya, A.V. Dudkov, T.V. Kvetnaya, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 4, pp. 680–684.

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Khavinson, V.K., Sevostyanova, N.N., Durnova, A.O. et al. Tetrapeptide stimulates functional activity of pancreatic cells in aging. Adv Gerontol 3, 220–224 (2013). https://doi.org/10.1134/S2079057013030053

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  • DOI: https://doi.org/10.1134/S2079057013030053

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