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The peptide Ala-Glu-Asp-Gly and interferon gamma: Their role in immune response during aging

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Abstract

The decrease in interferon gamma expression by lymphocytes during aging is one of the main mechanisms leading to an immunodeficiency state in the elderly. Cell-penetrating geroprotective peptide Ala-Glu-Asp-Gly has the ability to activate proliferation of lymphocytes in the thymus during its aging. The nucleotide sequence that complementary contacts with Ala-Glu-Asp-Gly has been found in the promoter region of interferon gamma gene. Thus, the immunoprotective effect of the peptide can be explained by activation of interferon gamma production in T cells.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, pr. Dinamo 3, St. Petersburg, 197110, Russia

    N. S. Lin’kova & V. Kh. Khavinson

  2. Chita State Medical Academy, ul. Gor’kogo 39a, Chita, 672000, Russia

    B. I. Kuznik

  3. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    V. Kh. Khavinson

Authors
  1. N. S. Lin’kova
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  2. B. I. Kuznik
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  3. V. Kh. Khavinson
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Correspondence to N. S. Lin’kova.

Additional information

Original Russian Text © N.S. Lin’kova, B.I. Kuznik, V.Kh. Khavinson, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 3, pp. 478–482.

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Lin’kova, N.S., Kuznik, B.I. & Khavinson, V.K. The peptide Ala-Glu-Asp-Gly and interferon gamma: Their role in immune response during aging. Adv Gerontol 3, 124–128 (2013). https://doi.org/10.1134/S2079057013020100

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  • DOI: https://doi.org/10.1134/S2079057013020100

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