Skip to main content
SpringerLink
Log in

CCR5, CCR2, apoE, p53, ITGB3, and HFE gene polymorphism in Western Siberian long livers

  • Published:
Advances in Gerontology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

In order to estimate the distribution of certain polymorphisms of the CCR5, CCR2, apoE, p53, ITGB3, and HFE genes in Russian long livers from Western Siberia, a sample of 271 individuals (age range 90–105 years) has been examined. It was demonstrated that carriage of the polymorphisms Δ32 (CCR5 gene), V64I (CCR2 gene), e2/e3/e4 (apoE gene), and L33P (ITGB3 gene), as well as the H63D and S65C polymorphisms of the HFE gene, does not affect predisposition to longevity; carriage of the 282Y allele of the HFE gene negatively affects longevity; carriage of the heterozygous genotype for the R72P polymorphism of the p53 gene correlates with longevity of elderly people.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Voevoda, M.I., Kulikov, I.V., Maksimov, V.N., et al., Sudden cardiac death and polymorphism of genes-candidates involved into cardiovascular disease development, Kardiologiya, 2009, no. 4, pp. 52–57.

    Google Scholar 

  2. Voevoda, M.I., Shishkin, S.V., Maximov, V.N., et al., apoE gene polymorphism and ischemic stroke in urban population of west Siberia, Bull. Sib. Branch, Russ. Acad. Med. Sci., 2010, no. 3, pp. 119–123.

    Google Scholar 

  3. Cherkashina, I.I., Nikulina, S.Yu., Logvinenko, N.I., et al., Polymorphism of CCR5 chemokine receptor gene in patients with branchial asthma and their relatives, Yakut. Med. Zh., 2009, no. 26, pp. 132–134.

    Google Scholar 

  4. Bathum, L., Christiansen, L., Nybo, H., et al., Association of the hemachromatosis gene with shorter life expectancy, Arch. Intern. Med., 2001, vol. 161, no. 20, pp. 2441–2444.

    Article  PubMed  CAS  Google Scholar 

  5. Choi, W.T. and An, J., Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases, Exp. Biol. Med. (Maywood), 2011, vol. 236, no. 6, pp. 637–647.

    Article  CAS  Google Scholar 

  6. Drenos, F. and Kirkwood, T.B., Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E, PLoS One, 2010, vol. 5, no. 4, p. e10022.

    Article  PubMed  Google Scholar 

  7. Feng, D., Lindpaintner, K., Larson, M.G., et al., Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study, Arterioscler., Thromb., Vasc. Biol., 1996, vol. 19, no. 4, pp. 1142–1147.

    Article  Google Scholar 

  8. Gerdes, L.U., Jeune, B., Ranberg, K.A., et al., Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: Apolipoprotein E gene is a “frailty gene”, not a “longevity gene”, Genet. Epidemiol., 2000, vol. 19, no. 3, pp. 202–210.

    Article  PubMed  CAS  Google Scholar 

  9. Hjelmborg, J., Iachine, I., Skytthe, A., et al., Genetic influence on human lifespan and longevity, Hum. Genet., 2006, vol. 119, no. 3, pp. 312–321.

    Article  Google Scholar 

  10. The Present Demographic Situation in Russian Federation. http://www.gks.ru/free-doc/2010/demo/dem-sit-09.doc

  11. Jiang, D.K., Yao, L., Wang, W.Z., et al., TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: A metaanalysis, World J. Gastroenterol., 2011, vol. 17, no. 9, pp. 1227–1233.

    Article  PubMed  CAS  Google Scholar 

  12. Mura, C., Raguenes, O., and Ferec, C., HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis, Blood, 1999, vol. 93, no. 8, pp. 2502–2505.

    PubMed  CAS  Google Scholar 

  13. Nandar, W. and Connor, J.R., HFE gene variants affect iron in the brain, J. Nutr., 2011, vol. 141, no. 4, pp. 729S–739S.

    Article  PubMed  CAS  Google Scholar 

  14. Orsted, D.D., Bojesen, S.E., Tybjaerg-Hansen, A., and Nordestgaard, B.G., Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival and risk of cancer in the general population, J. Exp. Med., 2007, vol. 204, no. 6, pp. 1295–1301.

    Article  PubMed  Google Scholar 

  15. Ortlepp, J.R., Vesper, K., Mevissen, V., et al., Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age, J. Mol. Med. (Berlin), 2003, vol. 81, no. 6, pp. 363–367.

    CAS  Google Scholar 

  16. Samson, M., Libert, F., and Donarz, B.J., Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene, Nature, 1996, vol. 382, no. 6593, pp. 722–725.

    Article  PubMed  CAS  Google Scholar 

  17. Sebastiani, G. and Walker, A.P., HFE gene in primary and secondary hepatic iron overload, World J. Gastroenterol., 2007, vol. 13, no. 35, pp. 4673–4689.

    PubMed  CAS  Google Scholar 

  18. Sebastiani, P., Solovieff, N., Puca, A., et al., Genetic signature of exceptional longevity in humans, Science Express, 2010. doi: 10.1371/journal.pone.0029848

    Google Scholar 

  19. Thomas, M., Kalita, A., Labrecque, S., et al., Two polymorphic variants of wild-type p53 differ biochemically and biologically, Mol. Cell. Biol., 1999, vol. 19, no. 2, pp. 1092–1100.

    PubMed  CAS  Google Scholar 

  20. Vijayan, K.V., Liu, Y., Dong, J.F., and Bray, P.F., Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3, J. Biol. Chem., 2003, vol. 278, no. 6, pp. 3860–3867.

    Article  PubMed  CAS  Google Scholar 

  21. Yudin, N., Vinogradov, S., Potapova, T., et al., Distribution of CCR5-delta32 gene deletion across the Russian part of Eurasia, Hum. Genet., 1998, vol. 102, no. 6, pp. 695–698.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk, 630090, Russia

    D. E. Ivanoshchuk, S. V. Mikhailova, I. V. Kulikov, M. I. Voevoda & A. G. Romashchenko

  2. Institute of Internal Medicine, Siberian Branch, Russian Academy of Sciences, ul. B. Bogatkova 175/1, Novosibirsk, 630089, Russia

    I. V. Kulikov, V. N. Maksimov & M. I. Voevoda

Authors
  1. D. E. Ivanoshchuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. V. Mikhailova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. V. Kulikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. N. Maksimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. I. Voevoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. G. Romashchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. E. Ivanoshchuk.

Additional information

Original Russian Text © D.E. Ivanoshchuk, S.V. Mikhailova, I.V. Kulikov, V.N. Maksimov, M.I. Voevoda, A.G. Romashchenko, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 3, pp. 3942–397.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ivanoshchuk, D.E., Mikhailova, S.V., Kulikov, I.V. et al. CCR5, CCR2, apoE, p53, ITGB3, and HFE gene polymorphism in Western Siberian long livers. Adv Gerontol 3, 89–92 (2013). https://doi.org/10.1134/S2079057013020082

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079057013020082

Keywords

Search

Navigation