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Age-related changes in 6-hydroxymelatonin sulfate excretion in patients with gastric and colorectal cancer

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Abstract

The age-related dynamics of 6-hydroxymelatonin sulfate (6-OHMS) excretion was studied in 175 patients with gastric (89 patients) and colorectal cancer (86 patients). An age-related decrease in 6-OHMS excretion and disturbances of its circadian rhythm were revealed. These changes were directly proportional to the prevalence of cancer and in the case of colorectal cancer, to the degree of lymphogenous metastasis.

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Authors and Affiliations

  1. Petrov Research Institute of Oncology, Pesochnyi-2, St. Petersburg, 197758, Russia

    M. N. Ermachenkov, A. V. Gulyaev & V. N. Anisimov

  2. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences, Mendeleevskaya liniya 3, St. Petersburg, 199034, Russia

    A. V. Arutyunyan & Yu. P. Milyutina

Authors
  1. M. N. Ermachenkov
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  2. A. V. Gulyaev
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  3. A. V. Arutyunyan
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  4. Yu. P. Milyutina
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  5. V. N. Anisimov
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Correspondence to M. N. Ermachenkov.

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Original Russian Text © M.N. Ermachenkov, A.V. Gulyaev, A.V. Arutyunyan, Yu.P. Milyutina, V.N. Anisimov, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 2, pp. 244–249.

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Ermachenkov, M.N., Gulyaev, A.V., Arutyunyan, A.V. et al. Age-related changes in 6-hydroxymelatonin sulfate excretion in patients with gastric and colorectal cancer. Adv Gerontol 3, 148–153 (2013). https://doi.org/10.1134/S2079057013020069

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  • DOI: https://doi.org/10.1134/S2079057013020069

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