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Role of oxidative stress in skin aging


The review covers the literature that prove that the formation of ROS in aging overbalances the antioxidant defence system potential of the skin structure (horny layer, epidermis, and dermis). It has been shown that ROSs are involved in the pathogenesis of inflammatory processes and allergic responses in the skin. The role of ROS and antioxidant systems in the cell-mediated responses associated with the MAP kinase activity in the skin is discussed. Special attention is focused on exposure to ultraviolet radiation, which accounts for its genotoxic, immunosuppressive, and carcinogenic effects on skin.

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Correspondence to L. S. Kozina.

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Original Russian Text © L.S. Kozina, I.V. Borzova, V.A. Arutiunov, G.A. Ryzhak, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 2, pp. 217–222.

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Kozina, L.S., Borzova, I.V., Arutiunov, V.A. et al. Role of oxidative stress in skin aging. Adv Gerontol 3, 18–22 (2013).

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  • oxidative stress
  • ROS
  • MAP kinases
  • skin antioxidant systems
  • fibroblasts
  • keratinocytes
  • carcinogenesis