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The antiatherosclerotic effects of a geroprotector peptide

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Abstract

The biological activity of a peptide-based geroprotector was studied on the basis of the calf aorta extract Slavinorm in experimental models of hyperlipidemia and acute myocardial infarction. The study results showed that Slavinorm has a pronounced antiatherogenic effect, which appeared in the optimization of the blood-lipid spectrum, including normalization of the atherogenicity factor due to an increase in the high-density lipids level and other cholesterol fractions decrease. In a model of acute myocardial infarction in rats, Slavinorm showed an antiischemic effect, which was expressed in a significant reduction in the necrotic zone after a 4-hour occlusion of the coronary artery, as compared with the parameters of the control animals, and a low incidence of postocclusion arrhythmias.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, pr. Dinamo 3, St. Petersburg, 197110, Russia

    A. P. Ryzhak, V. N. Rutkovskaya & G. A. Ryzhak

  2. Chita State Medical Academy, ul. Gor’kogo 39a, Chita, 672000, Russia

    B. I. Kuznik

Authors
  1. A. P. Ryzhak
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  2. B. I. Kuznik
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  3. V. N. Rutkovskaya
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  4. G. A. Ryzhak
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Correspondence to G. A. Ryzhak.

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Original Russian Text © A.P. Ryzhak, B.I. Kuznik, V.N. Rutkovskaya, G.A. Ryzhak, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 1, pp. 139–142.

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Ryzhak, A.P., Kuznik, B.I., Rutkovskaya, V.N. et al. The antiatherosclerotic effects of a geroprotector peptide. Adv Gerontol 2, 332–335 (2012). https://doi.org/10.1134/S2079057012040121

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