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Surface architectonics and the state of the cytoskeleton in thymocytes exposed to peroxynitrite from rats of different ages

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Abstract

In order to study the effects of aging on the response of cells of the immune system to a proinflammatory (oxidative) agent, we examined the influence of peroxynitrite at a concentration of 30 μM on the structure of the surface layer of the cytoskeleton of thymocytes in rats of different ages. In the absence of a proinflammatory agent, we did not observe any substantial differences in morphological or topological features of thymocytes in 3- and 8-month animals. Atomic force microscopy revealed that peroxynitrite activated actin structure assembly in the cytoskeleton of thymocytes of 3-month animals whereas, in 8-month animals, it induced disassembly of cytoskeleton structures. Our data improve understanding of age-related differences in the response of the immune system to inflammatory processes in the body.

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Authors and Affiliations

  1. Gomel’ State Medical University, ul. Lange 5, Gomel’, 246000, Belarus

    I. A. Nikitina, M. N. Starodubtseva & A. I. Grishchuk

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  1. I. A. Nikitina
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  2. M. N. Starodubtseva
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  3. A. I. Grishchuk
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Correspondence to I. A. Nikitina.

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Original Russian Text © I.A. Nikitina, M.N. Starodubtseva, A.I. Grishchuk, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 2, pp. 227–233.

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Nikitina, I.A., Starodubtseva, M.N. & Grishchuk, A.I. Surface architectonics and the state of the cytoskeleton in thymocytes exposed to peroxynitrite from rats of different ages. Adv Gerontol 2, 45–50 (2012). https://doi.org/10.1134/S2079057012010092

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