Abstract
The aim of the present work was to investigate the effect of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides, designed and synthesized according to the results of the investigation of amino acid composition of peptides found in the anterior and posterior lobes of the pituitary, on the morphology and hormone activity of the thyroid in sexually mature and old hens. Pituitary resection has been shown to cause thyroid atrophy and secondary hypothyreosis. Administration of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly tetrapeptides under these conditions largely alleviated these impairments, increasing the content of thyrotropic hormone, T 3, and T 4. The recovery of the hormonal function and thyroid morphology was nearer to being complete in 1-year old hens than in 5-year old hens.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Avtandilov, G.G., Meditsinskaya morfometriya (Medical Morphometry), Moscow: Meditsina, 1990.
Akmaev, I.G., Problems and Perspectives of Neuroimmunoendocrinology Development, Probl. Endokrinol., 1999, vol. 45, no. 5, pp. 3–8.
Akmaev, I.G. and Grinevich, V.V., From Neuroimmunology to Neuroimmunoendocrinology, Byul. Eksper. Biol., 2001, vol. 131, no. 1, pp. 22–32.
Ashmarin, I.P. and Karazeeva, E.P., New Roles of Highly-Stable Oligopeptides, Neurotrophines and Immunomodulators in Regulatory Continuum, Usp. Fiziol. Nauk, 2003, vol. 34, no. 1, pp. 14–19.
Ashmarin, I.P., Danilova, R.A., and Obukhova, M.F., Long Correction of the Brain Activity, Perspectives of Immunological Approaches, Vestn. Ross. Akad. Med. Nauk, 2001, no. 4, pp. 27–30.
Glants, S., Mediko-biologicheskaya statistika (Medicalbiological Statistics), Moscow: Praktika, 1999.
Epishin, A.V. and Gritsyv, V.V., Alterations in Immune Status at Primary Hypothyroidism, Probl. Endokrinol., 1989, no. 4, pp. 38–41.
Epishin, A.V., Gritsyv, V.E., and Venger, E.P., Immune Disturbances in Patients with Primary Hypothyroidism, Vrach. Delo, 1991, no. 6, pp. 51–53.
Kirillov, V.A., Yushchenko, Yu.P., and Demidchik, E.P., Morphometry of Thyroid Gland, Arkh. Patol., 1994, no. 3, pp. 65–68.
Kirichuk, V.F., Baluda, V.P., and Lukoyanova, T.I., Dysfunction of Platelets at Diffuse Toxic Goiter and Experimental Thyroxin Toxicosis, Probl. Endokrinol., 1981, vol. 27, no. 1, pp. 20–25.
Kuznik, B.I., Pateyuk, A.V., Baranchugova, L.M., and Rusaeva, N.S., Effect Epithalon and Kortagen on Immunity and Hemostasis in Neonatal Hypophysectomized and Older Chickens, Uspekhi Gerontol., 2008, vol. 21, no. 3, pp. 372–381.
Lilli, R., Patogistologicheskaya tekhnika i prakticheskaya gistokhimiya (Pathohistological Procedure and Practical Histochemistry), Moscow: Mir, 1969.
Pateyuk, A.V. and Kuznik, B.I., Effect of Pituitary Cytomedines on the State of the Hemostatic System in Hypophysectomized Chickens of Different Ages, Tromby, Krovotochivost’ i Bolezni Sosudov, 2003, no. 2, pp. 54–55.
Pateyuk, A.V. and Kuznik, B.I., Effect Cytomedines of the Front and Back Parts of the Hypophysis on Immunity and Hemostasis in Hypophysectomized Chickens, Immunologiya, 2003, no. 4, pp. 213–216.
Pateyuk, A.V., Kuznik, B.I., and Dzhulai, M.A., Gipofiz, immunitet i gemostaz (Hypophysis, Immunity and Homeostasis), Chita: Poisk, 2003.
Pateyuk, A.V., Kuznik, B.I., and Dzhulai, M.A., New Data on Hypophysis Role in Regulation of Cellular and Humoral Immunity, Allergol. i Immunol., 2003, no. 4(2), p. 199.
Pateyuk, A.V., Baranchugova, L.M., Dzhulai, M.A., and Kuznik, B.I., Effect of Peptides on the Immunity and the Morphological Structure of the Thymus and Bursa of Neonatal Hypophysectomized Chickens, Immunologiya, 2006, vol. 27, no. 6, pp. 337–342.
Pirs, E., Gistokhimiya (Histochemistry), Moscow, 1962.
Recher, S., Raccrt, M., and Lambert, A., Prenatal and Adult Growth Hormone Gene Expression in Rat Lymphoid Organs, J. Histochem. Cytochem., 2001, vol. 49, no. 3, pp. 347–354.
Khavinson, V.Kh., Peptides and Aging, Neuroendocrinol. Lett., 2002, vol. 23,Suppl. 3, Special Issue.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © B.I. Kuznik, A.V. Pateyuk, N.S. Rusaeva, L.M. Baranchugova, V.I. Obydenko, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 1, pp. 93–98.
Rights and permissions
About this article
Cite this article
Kuznik, B.I., Pateyuk, A.V., Rusaeva, N.S. et al. The effect of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormone activity and the thyroid structure in sexually mature and old hypophysectomized birds. Adv Gerontol 1, 340–345 (2011). https://doi.org/10.1134/S2079057011040072
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2079057011040072