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The Effect of the Porosity of Materials Based on Tricalcium Phosphate on the Behavior of Mesenchymal Stem Cells

  • MATERIALS FOR HUMAN LIFE SUPPORT AND ENVIRONMENTAL PROTECTION
  • Published:
Inorganic Materials: Applied Research Aims and scope

Abstract

The behavior of primarily isolated human stromal cells including dermal fibroblasts and mesenchymal stem/stromal cells (MSCs) upon interaction with ceramic materials based on tricalcium phosphate (TCP) with different pore sizes is studied. The effect of the emulsifier on the rheological characteristics of photosensitive emulsions based on calcium phosphate is investigated. The dependence of the conditions of preparation of photosensitive emulsions on the pore size in ceramic materials based on Ca3(PO4)2 is demonstrated. Studies of the biocompatibility of macroporous bioceramics upon cultivation of human stromal cells and effect of the samples of the material with different pore sizes on the in vitro transcriptional activity of MSCs are carried out.

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ACKNOWLEDGMENTS

The results presented in the work were obtained on the equipment of the Research Equipment Sharing Center of Physical Methods for Studying Substances and Materials, Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, as well as on the equipment procured at the expense of the Development Program of the Moscow State University.

Funding

This work was financially supported by the Russian Science Foundation (grant no. 20-79-10210).

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Authors and Affiliations

  1. Lomonosov Moscow State University, 119991, Moscow, Russia

    P. V. Evdokimov, A. K. Kiseleva, D. S. Larionov, E. S. Novoseletskaya, A. Yu. Efimenko, I. M. Scherbakov, G. A. Shipunov, V. E. Dubrov & V. I. Putlayev

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  1. P. V. Evdokimov
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  2. A. K. Kiseleva
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  3. D. S. Larionov
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  4. E. S. Novoseletskaya
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  5. A. Yu. Efimenko
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  6. I. M. Scherbakov
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  7. G. A. Shipunov
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  8. V. E. Dubrov
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  9. V. I. Putlayev
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Correspondence to P. V. Evdokimov, A. K. Kiseleva, D. S. Larionov, E. S. Novoseletskaya, A. Yu. Efimenko, I. M. Scherbakov, G. A. Shipunov, V. E. Dubrov or V. I. Putlayev.

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Translated by E. Boltukhina

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Evdokimov, P.V., Kiseleva, A.K., Larionov, D.S. et al. The Effect of the Porosity of Materials Based on Tricalcium Phosphate on the Behavior of Mesenchymal Stem Cells. Inorg. Mater. Appl. Res. 14, 1285–1291 (2023). https://doi.org/10.1134/S2075113323050118

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  • DOI: https://doi.org/10.1134/S2075113323050118

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