Abstract—
Supercritical fluid encapsulation of gentamicin, levofloxacin and tetracycline into bioresorbable poly(lactic-co-glycolic)acid (PLGA) scaffolds at 20 wt % was performed by PLGA plasticization in supercritical carbon dioxide with its subsequent foaming. The effect of incorporated antibiotics on the rate of PLGA hydrolytic degradation, determined by weekly measurements of the polymer molecular weight and decrease in gravitational masses during 6 weeks of incubation of scaffolds in a phosphate-buffered saline (PBS) solution, was studied. Measurements of pH of PBS containing scaffolds were carried out in the same way. The rate constants of PLGA hydrolysis for different scaffolds comprising various drugs were determined. It was shown that tetracycline significantly reduced the rate of PLGA degradation compared to the rate of degradation of control (pure polymer) scaffolds. At the same time, the presence of gentamicin and levofloxacin in the scaffolds had no visible effect on their degradation. These results enhance the predicting potential for the kinetics of release of the considered antibiotics from bioresorbable polymer carriers into bioactive media, which is necessary for the development of highly efficient sustained-release dosage forms.
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Yun, Y., Lee, B.K., and Park, K., Controlled drug delivery systems: The next 30 years, Front. Chem. Sci. Eng., 2014, vol. 8, no. 3, pp. 276–279.
Weiser, J.R. and Saltzman, W.M., Controlled release for local delivery of drugs: Barriers and models, J. Controlled Release, 2014, vol. 190, pp. 664–673.
Pandey, R., Sharma, A., Zahoor, A., Sharma, S., Khuller, G.K., and Prasad, B., Poly (d,l-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis, J. Antimicrob. Chemother., 2003, vol. 52, no. 6, pp. 981–986.
Nair, L.S. and Laurencin, C.T., Biodegradable polymers as biomaterials, Prog. Polym. Sci., 2007, vol. 32, pp. 762–798.
Kedik, S.A., Zhavoronok, E.S., Sedishev, I.P., Panov, A.V., Suslov, V.V., Petrova, E.A., Sapel’nikov, M.D., Shatalov, D.O., and Eremin, D.V., Polymers for systems of delivery of prolonged-acting drugs (review). Polymers and copolymers of lactic and glycolic acids, Razrab. Registr. Lekar. Sredstv, 2013, no. 2 (3), pp. 18–26. https://elibrary.ru/item.asp?id=20298831
Antonov, E.N., Dunaev, A.G., Minaeva, S.A., Krotova, L.I., and Popov, V.K., Effects of pharmaceutical preparations on the rate of degradation of poly(lactide-co-glycolide) scaffolds, Pharm. Chem. J., 2018, vol. 52, no. 1, pp. 69–76.
Report of the WHO Expert Committee on Selection and Use of Essential Medicines, The selection and use of essential medicines, WHO Tech. Rep. Ser., 2019, no. 1021. http://www.who.int/medicines/publications/essentialmedicines/en/index.html
Bogorodskii, S.E., Krotova, L.I., Mironov, A.V., and Popov, V.K., Fabrication of highly porous bioresorbable polymer matrices using supercritical carbon dioxide, Russ. J. Phys. Chem. B, 2013, vol. 7, no. 8, pp. 916–923.
Gumerov, F.M., Sabirzyanov, A.N., and Gumerova, G.I., Sub- i sverkhkriticheskie flyuidy v protsessakh pererabotki polimerov (Sub- and Supercritical Fluids in Polymer Processing), Kazan: FEN, 2000.
Hakkarainen, M., Albertsson, A.C., and Karlsson, S., Weight losses and molecular weight changes correlated with the evolution of hydroxyacids in simulated in vivo degradation of homo- and copolymers of PLA and PGA, Polym. Degrad. Stab., 1996, vol. 52, pp. 283–291.
Borovikov, P.I., Sviridov, A.P., Antonov, E.N., Dunaev, A.G., Krotova, L.I., Fatkhudinov, T.Kh., and Popov, V.K., Model of aliphatic polyesters hydrolysis comprising water and oligomers diffusion, Polym. Degrad. Stab., 2019, vol. 159, pp. 70–78.
Engineer, C., Parikh, J., and Raval, A., Review on hydrolytic degradation behavior of biodegradable polymers from controlled drug delivery system, Trends Biomater. Artif. Organs, 2011, vol. 25, pp. 79–85.
Makadia, H.K. and Siegel, S.J., Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier, Polymers, 2011, vol. 3, no. 3, pp. 1377–1397.
Siepmann, J., Elkharraz, K., Siepmann, F., and Klose, D., How autocatalysis accelerates drug release from PLGA-based microparticles: A quantitative treatment, Biomacromolecules, 2005, vol. 6, pp. 2312–2319.
Cha, Y. and Pitt, C.G., The acceleration of degradation controlled drug delivery from polyester microspheres, J. Controlled Release, 1988, vol. 8, pp. 259–265.
Frank, A., Rath, S.K., and Venkatraman, S.S., Controlled release from bioerodible polymers: Effect of drug type and polymer composition, J. Controlled Release, 2005, vol. 102, pp. 333–344.
Zolnik, B.S. and Burgess, D.J., Effect of acidic pH on PLGA microsphere degradation and release, J. Controlled Release, 2007, vol. 122, pp. 338–344.
Chen, X., Ooi, C.P, and Lim, T.H., Effect of ganciclovir on the hydrolytic degradation of poly(lactide-co-glycolide) microspheres, J. Biomater. Appl., 2006, vol. 20, pp. 287–302.
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This work was supported by the Ministry of Science and Higher Education within the framework of the State Assignment of the Federal Scientific Research Centre Crystallography and Photonics of the Russian Academy of Sciences (development of SCF methods for the formation of bioactive matrix structures) and by the Russian Foundation for Basic Research (grant no 18-29-06062 mk) (development of dosage forms of prolonged action).
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Antonov, E.N., Dunaev, A.G., Krotova, L.I. et al. Effect of Antibacterial Drugs on Hydrolytic Degradation of Aliphatic Polyesters. Inorg. Mater. Appl. Res. 13, 854–860 (2022). https://doi.org/10.1134/S2075113322030042
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DOI: https://doi.org/10.1134/S2075113322030042