Skip to main content
SpringerLink
Log in

Powder Mixtures Based on Calcium Hydroxyapatite and Sodium Salts

  • Published:
Inorganic Materials: Applied Research Aims and scope

Abstract

Powder mixtures based on calcium hydroxyapatite (HAP) and sodium salts in the amount corresponding to 25 mol % of Na2O in the Na2O–CaO–P2O5 system were studied by isothermal exposures in the range of 600—1200°C. According to XRD data, the phase composition of the samples of HAP/Na2CO3 after calcination included HAP, β-CaNaPO4, and CaO. The phase composition of the ceramic samples from the HAP/Na2HPO4 powder mixture after calcination contained the phases of β-CaNaPO4 and Na4P2O7. The phase composition of the ceramic samples from the powder mixture of HAP/NaH2PO4 after calcination contained Ca2P2O7, Ca10Na(PO4)7, β-CaNaPO4, CaNa2P2O7, and Na4P2O7. The presence of sodium salts in the amount corresponding to 25 mol % of Na2O in the Na2O–CaO–P2O5 system provided the occurrence of liquid- phase sintering in compact preforms from the studied powder mixtures. However, the presence of the water-soluble salt Na4P2O7 in ceramic samples of HAP/Na2HPO4 and HAP/NaH2PO4 after calcination imposes a restriction on the use of such materials in contact with an aqueous medium. And the presence of CaO in the HAP/Na2CO3 samples excludes the use of such materials as bone implants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barinov, S.M., Calcium phosphate-based ceramic and composite materials for medicine, Russ. Chem. Rev., 2010, vol. 79, no. 1, pp. 13–30.

    Article  CAS  Google Scholar 

  2. Safronova, T.V. and Putlyaev, V.I., Powder systems for calcium phosphate ceramics, Inorg. Mater., 2017, vol. 53, no. 1, pp. 17–26.

    Article  CAS  Google Scholar 

  3. Danil’chenko, S.N., Structure and properties of calcium apatites in terms of biomineralogy and biomaterial science (review), Visn. Sumsk. Derzh. Univ., Ser. Fiz., Matem., Mekh., 2007, no. 2, pp. 33–59.

    Google Scholar 

  4. Gerk, S.A. and Golovanova, O.A., Elemental composition of human bone tissue in norm and pathology, Vestn. Omsk. Gos. Univ., 2015, no. 4 (78), pp. 39–44.

    Google Scholar 

  5. Putlyaev, V.I. and Safronova, T.V., A new generation of calcium phosphate biomaterials: the role of phase and chemical compositions, Glass Ceram., 2006, vol. 63, nos. 3–4, pp. 99–102.

    Article  CAS  Google Scholar 

  6. Parent, M., Baradari, H., Champion, E., Damia, C., and Viana-Trecant, M., Design of calcium phosphate ceramics for drug delivery applications in bone diseases: A review of the parameters affecting the loading and release of the therapeutic substance, J. Controlled Release, 2017, vol. 252, pp. 1–17.

    Article  CAS  Google Scholar 

  7. Safronova, T.V. and Putlyaev, V.I., Medical inorganic materials science in Russia: calcium phosphate materials, Nanosist.: Fiz., Khim., Matem., 2013, vol. 4, no. 1, pp. 24–47.

    Google Scholar 

  8. Suchanek, W., Yashima, M., Kakihana, M., and Yoshimura, M., Hydroxyapatite ceramics with selected sintering additives, Biomaterials, 1997, vol. 18, pp. 923–933.

    Article  CAS  PubMed  Google Scholar 

  9. Kalita, S.J., Bose, S., Hosick, H.L., and Bandyopadhyay, A., CaO–P2O5–Na2O-based sintering additives for hydroxyapatite (HAp) ceramics, Biomaterials, 2004, vol. 25, pp. 2331–2339.

    Article  CAS  PubMed  Google Scholar 

  10. ICDD, PDF-4 + 2010 (Database), Kabekkodu, S., Ed., Newtown Square: Int. Centre Diffraction Data, 2010. https://doi.org/www.icdd.com/products/pdf2.htm

Download references

Author information

Authors and Affiliations

  1. Moscow State University, Moscow, Russia

    T. V. Safronova, V. I. Putlyayev, A. V. Knotko, Ya. Yu. Filippov, E. S. Klimashina, A. P. Ryzhov & B. M. Saidzhonov

Authors
  1. T. V. Safronova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. I. Putlyayev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Knotko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ya. Yu. Filippov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. S. Klimashina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. P. Ryzhov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B. M. Saidzhonov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. V. Safronova.

Additional information

Original Russian Text © T.V. Safronova, V.I. Putlyayev, A.V. Knotko, Ya.Yu. Filippov, E.S. Klimashina, A.P. Ryzhov, B.M. Saidzhonov, 2018, published in Materialovedenie, 2018, No. 1, pp. 43–48.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Safronova, T.V., Putlyayev, V.I., Knotko, A.V. et al. Powder Mixtures Based on Calcium Hydroxyapatite and Sodium Salts. Inorg. Mater. Appl. Res. 9, 726–731 (2018). https://doi.org/10.1134/S2075113318040342

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2075113318040342

Keywords

Search

Navigation