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Long-acting bioactive composition based on chitosan and taxifolin

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Inorganic Materials: Applied Research Aims and scope

Abstract

Chitosan-based hydrogel containing antioxidant dihydroquercetin is developed. The optimal concentration of a cross-linking agent making it possible to obtain viscous fluid chitosan hydrogels capable of protractedly producing dihydroquercetin is found. During hydrogel formation and its storage, 86% of dihydroquercetin remains in the initial form, and production of no more than 14% of thermal oxidation products is observed. At the same time, the original content of the flavonoid in the hydrogel is shown to be 5 times greater than its solubility in water; the dihydroquercetin isolation from the hydrogel is 4 times slower than from a chitosan solution. Adaptogenic activity of hydrogel was demonstrated under hypobaric hypoxia conditions in vivo orally applied to experimental animals.

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Authors and Affiliations

  1. Lobachevsky State University of Nizhny Novgorod, pr. Gagarina 23, Nizhny Novgorod, 603950, Russia

    I. A. Baranov, D. Yu. Dzhons, A. V. Budruev, A. E. Mochalova, L. A. Smirnova & A. S. Koryagin

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  1. I. A. Baranov
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  2. D. Yu. Dzhons
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  3. A. V. Budruev
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  4. A. E. Mochalova
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  5. L. A. Smirnova
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  6. A. S. Koryagin
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Correspondence to I. A. Baranov.

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Original Russian Text © I.A. Baranov, D.Yu. Dzhons, A.V. Budruev, A.E. Mochalova, L.A. Smirnova, A.S. Koryagin, 2015, published in Perspektivnye Materialy, 2015, No. 3, pp. 40–47.

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Baranov, I.A., Dzhons, D.Y., Budruev, A.V. et al. Long-acting bioactive composition based on chitosan and taxifolin. Inorg. Mater. Appl. Res. 6, 479–484 (2015). https://doi.org/10.1134/S2075113315050020

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  • DOI: https://doi.org/10.1134/S2075113315050020

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