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The effect of graphene oxide (GO) on biomineralization and solubility of calcium hydroxyapatite (HA)

  • New Materials and Coatings in Biology and Medicine
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Abstract

Interaction between GO and the counterpart of the bone tissue, calcium hydroxyapatite Ca10(PO4)6(OH)2 (HA), is modeled in the course of synthesis of nanosize composite materials (CMs) based on graphene oxide (GO) and biocompatible HA with a GO content of 0.1, 1.0, 2.0, and 5.0 wt % GO from aqueous solutions in the system of Ca(OH)2–H3PO4–GO–H2O under native conditions (37°C). The effect of CM composition on the size and morphology of HA nanocrystals (HA NCs) is determined using the methods of physico-chemical analysis (chemical, XRD, IRS, DTA, TDG, SEM, TEM). The solubility of HA NC CMs by Ca2+ ions in distilled water is determined under in vitro conditions, and the possible results of interaction between GO and native calcified tissues are analyzed.

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    N. A. Zakharov, L. I. Demina & V. T. Kalinnikov

  2. Tambov State Technical University, Tambov, Russia

    A. G. Tkachev

  3. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia

    M. R. Kiselev

Authors
  1. N. A. Zakharov
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  2. A. G. Tkachev
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  3. L. I. Demina
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  4. M. R. Kiselev
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  5. V. T. Kalinnikov
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Correspondence to N. A. Zakharov.

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Original Russian Text © N.A. Zakharov, A.G. Tkachev, L.I. Demina, M.R. Kiselev, V.T. Kalinnikov, 2016, published in Fizikokhimiya Poverkhnosti i Zashchita Materialov, 2016, Vol. 52, No. 4, pp. 412–423.

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Zakharov, N.A., Tkachev, A.G., Demina, L.I. et al. The effect of graphene oxide (GO) on biomineralization and solubility of calcium hydroxyapatite (HA). Prot Met Phys Chem Surf 52, 665–676 (2016). https://doi.org/10.1134/S2070205116020337

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  • DOI: https://doi.org/10.1134/S2070205116020337

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