Abstract
Due to the growing problem of antibiotic resistance, the possibility of using alkylene guanidines as compounds exhibiting antimicrobial activity is discussed. Methods for the preparation of oligohexamethylene guanidine (OHMG) dihydrocarbonate using microfluidic technologies and the further synthesis of OHMG hydrocitrate are described. Structures of the compounds obtained were confirmed by 13С NMR spectroscopy, and the antimicrobial activity of OHMG hydrocitrate was evaluated.
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Shatalov, D.O., Ivanov, I.S., Aydakova, A.V. et al. Microfluidic Synthesis of Oligohexamethylene Guanidine Hydrocitrate and Study of Its Antimicrobial Activity. Polym. Sci. Ser. D 16, 415–419 (2023). https://doi.org/10.1134/S1995421223020375
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DOI: https://doi.org/10.1134/S1995421223020375