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Biocomposites for Oncological Treatment Based on Ultrafine Polyhydroxybutyrate Fibers Obtained by Electrospinning

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Abstract

This work shows the effectiveness of using biocomposites based on nonwoven fibrous materials for the treatment of cancer. Polyhydroxybutyrate nonwoven materials were obtained by electrospinning. Hydroxyapatite was introduced into the interior of the fibers, and a porous film was created on the surface of the nonwoven material. Both the types of matrices included the anticancer drug endoxan. It was shown that the fiber-based matrices have a low endoxan release rate, while the film-coated matrices are characterized by a high rate of endoxan release.

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ACKNOWLEDGMENTS

This work was partly supported by the Russian Foundation for Basic Research (grant no. 15-29-04862 ofi_m) (V.N. Gorshenev) and by a subsidy allocated by the Institute of Chemical Physics of the Russian Academy of Sciences for a state assignment (topic number of the Federal Agency of Scientific Organizations 0082-2014-0009, state registration no. AAAA-A17-117040610309-0) (A.L. Iordanskii).

Measurements were carried out using the equipment of the Center of Collective Use New Materials and Technologies of the Institute of Biochemical Physics, Russian Academy of Sciences.

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Authors and Affiliations

  1. Plekhanov Russian University of Economics, 117997, Moscow, Russia

    A. A. Ol’khov

  2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119991, Moscow, Russia

    A. A. Ol’khov & V. N. Gorshenev

  3. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991, Moscow, Russia

    A. A. Ol’khov & A. L. Iordanskii

  4. Sechenov First Moscow State Medical University, Ministry of Health of Russia, 119991, Moscow, Russia

    I. A. Muravlev & M. G. Strashnova

Authors
  1. A. A. Ol’khov
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  2. V. N. Gorshenev
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  3. I. A. Muravlev
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  4. M. G. Strashnova
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  5. A. L. Iordanskii
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Correspondence to A. A. Ol’khov.

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Translated by K. Lazarev

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Ol’khov, A.A., Gorshenev, V.N., Muravlev, I.A. et al. Biocomposites for Oncological Treatment Based on Ultrafine Polyhydroxybutyrate Fibers Obtained by Electrospinning. Polym. Sci. Ser. D 12, 218–222 (2019). https://doi.org/10.1134/S1995421219020175

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