Nanotechnologies in Russia

, Volume 9, Issue 9–10, pp 571–576 | Cite as

Silver-nanoparticle exposure on immune system of mice depending on the route of administration

  • O. V. Kalmantaeva
  • V. V. Firstova
  • V. D. Potapov
  • E. V. Zyrina
  • V. N. Gerasimov
  • E. A. Ganina
  • V. A. Burmistrov
  • A. V. Borisov
Article

Abstract

In this study we have identified the influence of Argovit on the immune system of mice after inhalation or intragastric or subcutaneous administration. Argovit is a preparation of polyvinylpyrrolidone-coated (43.6 ± 10.7 nm) silver nanoparticles. We have found no toxic effect on the immune cells and organs, changes in T- and B-lymphocytes quantity in the spleen, or proinflammatory cytokine production after exposure to silver nanoparticles through inhalation or intragastrically. The subcutaneous administration of silver nanoparticles has changed the ratio of lymphocyte subpopulations, increased the quantity of IFN-γ-producing T-lymphocytes 3.6-fold compared with the control, and increased the content of IFN-γ in the serum of mice to 125 ± 9.2 pg/mL compared to the control (74.5 ± 6.4 pg/mL).

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • O. V. Kalmantaeva
    • 1
  • V. V. Firstova
    • 1
  • V. D. Potapov
    • 1
  • E. V. Zyrina
    • 1
  • V. N. Gerasimov
    • 1
  • E. A. Ganina
    • 1
  • V. A. Burmistrov
    • 2
  • A. V. Borisov
    • 1
  1. 1.State Research Centre of Applied Microbiology and BiotechnologyObolensk, Moscow oblastRussia
  2. 2.Scientific-Production Centre “Vektor-Vita,”NovosibirskRussia

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