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Flexible biological sensors based on carbon nanotube films

Abstract

This paper presents the technique of forming flexible liquid sensors for biological applications based on carbon nanotube networks. We bend structures with a radius of curvature of 5 mm and the resistance change is no more than 8–10%, keeping the overall properties of the conductive coatings developed during multiple bends. We demonstrate the possibility of determining thrombin when biosensor structures are immobilized by specific aptamers.

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References

  1. D. Ha, W. N. Vries, S. W. M. John, P. P. Irazoqui, and W. J. Chappell, “Polymer-based miniature flexible capacitive pressure sensor for intraocular pressure (IOP) monitoring inside a mouse eye,” Biomed. Microdevices 14(1), 207–215 (2012).

    Article  Google Scholar 

  2. B. Zhang and T. Cui, “An ultrasensitive and low-cost graphene sensor based on layer-by-layer nano self-assembly,” Appl. Phys. Lett. 98, 073116–073118 (2011).

    Article  Google Scholar 

  3. P. Hu, J. Zhang, L. Li, Z. Wang, W. O’Neill, and P. Estrela, “Carbon nanostructure-based field-effect transistors for label-free chemical/biological sensors,” Sensors 10(5), 5133–5159 (2010).

    Article  Google Scholar 

  4. H. Y. Jeong, D.-S. Lee, H. K. Choi, D. H. Lee, J.-E. Kim, J. Y. Lee, W. J. Lee, S. O. Kim, and S.-Y. Choi, “Flexible room-temperature, NO2 gas sensors based on carbon nanotubes/reduced grapheme hybrid films,” Appl. Phys. Lett. 96, 213105–213107 (2010).

    Article  Google Scholar 

  5. A. Gohier, A. Dhar, L. Gorintin, P. Bondavalli, Y. Bonnassieux, and C. S. Cojocaru, “All-printed infrared sensor based on multiwalled carbon nanotubes,” Appl. Phys. Lett. 98, 063103–063105 (2011).

    Article  Google Scholar 

  6. G. Yang, C. Lee, J. Kim, F. Ren, and S. J. Pearton, “Flexible graphene-based chemical sensors on paper substrates,” Phys. Chem. Chem. Phys. 15, 1798–1801 (2013).

    Article  Google Scholar 

  7. Y. H. Kwak, D. S. Choi, Y. N. Kim, H. Kim, D. H. Yoon, S.-S. Ahn, J.-W. Yang, W. S. Yang, and S. Seo, “Flexible glucose sensor using CVD-grown graphene-based field effect transistor,” Biosens. Bioelectron. 37(1), 82–87 (2012).

    Article  Google Scholar 

  8. A. Star, E. Tu, J. Niemann, J.-C. P. Gabriel, C. S. Joiner, and C. Valcke, “Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors,” Proc. Nat. Acad. Sci. USA 103(4), 921–926 (2006).

    Article  Google Scholar 

  9. X. Tang, S. Bangsaruntip, N. Nakayama, E. Yenilmez, Y.-I. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).

    Article  Google Scholar 

  10. X. Zhou, J. M. Moran-Mirabal, H. G. Craighead, and P. L. McEuen, “Supported lipid bilayer/carbon nanotube hybrids,” Nature Nanotechnol. 2(3), 185–190 (2007).

    Article  Google Scholar 

  11. G. Gruner, “Carbon nanotube transistors for biosensing applications,” Anal. Bioanal. Chem. 384(2), 322–335 (2006).

    Article  Google Scholar 

  12. A. B. Artyukhin, M. Stadermann, R. W. Friddle, P. Stroeve, O. Bakajin, and A. Noy, “Controlled electrostatic gating of carbon nanotube FET devices,” Nano Lett. 6(9), 2080–2085 (2006).

    Article  Google Scholar 

  13. H.-M. So, K. Won, Y. H. Kim, B.-K. Kim, B. H. Ryu, P. S. Na, H. Kim, and J.-O. Lee, “Single-walled carbon nanotube biosensors using aptamers as molecular recognition elements,” J. Am. Chem. Soc. 127(34), 11906–11907 (2005).

    Article  Google Scholar 

  14. Y. Wang, Z. Yang, Z. Hou, D. Xu, L. Wei, E. S.-W. Kong, and Y. Zhang, “Flexible gas sensors with assembled carbon nanotube thin films for DMMP vapor detection,” Sensors Actuators B: Chem. 150(2), 708–714 (2010).

    Article  Google Scholar 

  15. D. J. Lipomi, M. Vosgueritchian, B. C-K. Tee, S. L. Hellstrom, J. A. Lee, C. H. Fox, and Z. Bao, “Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes,” Nature Nanotechnol. 6, 788–792 (2011).

    Article  Google Scholar 

  16. K. Parikh, K. Cattanach, R. Rao, D.-S. Suh, A. Wu, and S. K. Manohar, “Flexible vapour sensors using single walled carbon nanotubes,” Sensors Actuators B: Chem. 113(1), 55–63 (2006).

    Article  Google Scholar 

  17. T. An, K. S. Kim, S. K. Hahn, and G. Lim, “Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors,” Lab Chip. 10, 2052–2056 (2010).

    Article  Google Scholar 

  18. I. Heller and A. M. Janssens, J. Männik, E. D. Minot, S. G. Lemay, and C. Dekker, “Identifying the mechanism of biosensing with carbon nanotube transistors,” Nano Lett. 8(2), 591–595 (2008).

    Article  Google Scholar 

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Correspondence to V. K. Nevolin.

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Original Russian Text © K.F. Akhmadishina, I.I. Bobrinetskii, I.A. Komarov, A.M. Malovichko, V.K. Nevolin, V.A. Petukhov, A.V. Golovin, A.O. Zalevskii, 2013, published in Rossiiskie Nanotekhnologii, 2013, Vol. 8, Nos. 11–12.

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Akhmadishina, K.F., Bobrinetskii, I.I., Komarov, I.A. et al. Flexible biological sensors based on carbon nanotube films. Nanotechnol Russia 8, 721–726 (2013). https://doi.org/10.1134/S1995078013060025

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  • DOI: https://doi.org/10.1134/S1995078013060025

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