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Characterization of physicochemical parameters of nanoparticles formed from modified chitosan

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Abstract

Chitosan is a biodegradable and biocompatible polysaccharide widely used in different applications in medicine. The polycationic structure of the polymer provides many possibilities for its modification. One of the most interesting applications of chitosan is the development of nanosized delivery systems for biologically active molecules. The functional properties of these delivery systems depend severely on the structure and properties of nanoparticles. Using dynamic light scattering, atomic force microscopy, and to confocal microscopy, we have shown that both hexanoyl chitosan (HC) and succinoyl chitosan (SC) formed nanoparticles of comparable diameters from 120 to 250 nm. Using several methods of analysis helped us identify a minor fraction with a larger size of 600 to 700 nm formed by nanoparticle aggregates. The determined ζ potential was from −20 to −25 mV for SC nanoparticles and from 30 to 35 mV for HC nanoparticles.

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Authors and Affiliations

  1. Bioenginering Center, Russian Academy of Sciences, Moscow, Russia

    A. A. Zubareva, D. V. Kurek & V. P. Varlamov

  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    S. V. Sizova & E. V. Svirshchevskaya

Authors
  1. A. A. Zubareva
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  2. D. V. Kurek
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  3. S. V. Sizova
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  4. E. V. Svirshchevskaya
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  5. V. P. Varlamov
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Correspondence to A. A. Zubareva.

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Original Russian Text © A.A. Zubareva, D.V. Kurek, S.V. Sizova, E.V. Svirshchevskaya, V.P. Varlamov, 2012, published in Rossiiskie Nanotekhnologii, 2012, Vol. 7, Nos. 7–8.

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Zubareva, A.A., Kurek, D.V., Sizova, S.V. et al. Characterization of physicochemical parameters of nanoparticles formed from modified chitosan. Nanotechnol Russia 7, 428–433 (2012). https://doi.org/10.1134/S1995078012040167

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  • DOI: https://doi.org/10.1134/S1995078012040167

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