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Surface modification of Fe3O4 magnetic nanoparticles with (S)-naproxen

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Abstract

Fe3O4 magnetic nanoparticles (MNPs) were obtained using the gas condensation method. These MNPs were modified with 3-aminopropylsilane (APS) through covalent bonding. The methods of qualitative and quantitative analysis of the modified MNPs were developed using UV and IR spectroscopy and inductively coupled plasma emission spectrometry (ICP-ES). It was established that the maximum loading level of APS on the surface of Fe3O4 MNPs was 0.91 mmol/g MNP. The study of the activity of the surface amino groups of the nanocomposites was carried out by the example of their modification with (S)-naproxen. The optimum conditions for coupling reaction were found. It was shown that the reaction proceeded most efficiently when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as coupling agent in the presence of 1-hydroxy-1H-benzotriazole (HOBt). The maximum immobilization level of (S)-naproxen on the Fe3O4 MNP surface was 0.55 mmol/g MNP. Thus, the high reactivity of amino groups of the obtained nano-composites was shown, making it possible to further modify them.

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Authors and Affiliations

  1. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620041, Russia

    A. M. Demin & V. P. Krasnov

  2. Institute of Metal Physics, Ural Branch, Russian Academy of Sciences, ul. S. Kovalevskoi 18, Yekaterinburg, GSP-170, 620990, Russia

    M. A. Uimin, N. N. Shchegoleva & A. E. Yermakov

Authors
  1. A. M. Demin
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  2. M. A. Uimin
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  3. N. N. Shchegoleva
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  4. A. E. Yermakov
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  5. V. P. Krasnov
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Correspondence to A. M. Demin.

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Original Russian Text © A.M. Demin, M.A. Uimin, N.N. Shchegoleva, A.E. Yermakov, V.P. Krasnov, 2012, published in Rossiiskie Nanotekhnologii, 2012, Vol. 7, Nos. 3–4.

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Demin, A.M., Uimin, M.A., Shchegoleva, N.N. et al. Surface modification of Fe3O4 magnetic nanoparticles with (S)-naproxen. Nanotechnol Russia 7, 132–139 (2012). https://doi.org/10.1134/S199507801202005X

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  • DOI: https://doi.org/10.1134/S199507801202005X

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