Abstract
The effect of pressure on the size and morphology of particles of levofloxacin hydrochloride precipitated by supercritical antisolvent precipitation was studied. It was shown that crystallization of levofloxacin from the two-phase system CO2–dimethylformamide–levofloxacin hydrochloride gives particles with a bimodal size distribution. Crystallization from a single-phase system is accompanied by a change in the mechanism of mixing of CO2 and solution and, as a consequence, yields particles with a unimodal size distribution. For the first time, liquid–gas equilibrium curves for the CO2–dimethylformamide– levofloxacin hydrochloride system at a temperature of 40°C were constructed.
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ACKNOWLEDGMENTS
The studies of samples by scanning electron microscopy and X-ray powder diffraction analysis were carried out using the equipment of the Center for Shared Use of Physical Methods for the Study of Substances and Materials, Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Funding
This work was supported by the Russian Science Foundation (grant no. 22-23-00566).
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Translated by V. Glyanchenko
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Vorobei, A.M., Rubtsov, Y.P., Zuev, Y.I. et al. Supercritical Antisolvent Precipitation of Levofloxacin Hydrochloride from a Single-Phase and a Two-Phase CO2–Dimethylformamide Mixture. Russ. J. Phys. Chem. B 17, 1657–1664 (2023). https://doi.org/10.1134/S1990793123080109
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DOI: https://doi.org/10.1134/S1990793123080109