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Biopolymer Aerogels as Nasal Drug Delivery Systems

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Abstract

Protein (eggwhite) and chitosan aerogel microparticles characterized by low density, developed morphology, high specific surface area, high porosity, large volume, and small pore diameter, have been obtained. Particle size distribution curves were obtained by laser diffraction, from which the number average and aerodynamic diameters were calculated. The aerodynamic diameter of all of the obtained biopolymer aerogels lies in the range required for targeted delivery of active pharmaceutical ingredients (APIs) to the olfactory region of the nasal cavity. Experimental studies were performed to introduce the “melatonin” API in the pores of biopolymer aerogels at the solvent replacement and supercritical adsorption steps. The mass fractions of APIs in the resulting biopolymer aerogel–API pharmaceutical composites were determined by high-performance liquid chromatography. An X-ray powder diffraction analysis showed that API was present in pharmaceutical compositions mainly in the amorphous state. The results of in vivo experimental studies showed that in the case of intranasal administration of both biopolymer aerogel–API composites, the maximum concentration of API in brain tissues is reached already after 30 min. This proves that the obtained biopolymer aerogels based on protein (eggwhite) and chitosan are promising for use as API carrier matrices in the development of nasal drug delivery systems.

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Funding

This study was supported by the Ministry of Education and Science, Russian Federation (grant no. 075-15-2020-792, unique identifier RF-190220X0031).

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Authors and Affiliations

  1. Mendeleev University of Chemical Technology of Russia, 125047, Moscow, Russia

    N. V. Menshutina, A. A. Uvarova, M. S. Mochalova, D. D. Lovskaya & P. Yu. Tsygankov

  2. Serbsky National Medical Research Center of Psychiatry and Narcology, 119034, Moscow, Russia

    O. I. Gurina, E. A. Zubkov & O. V. Abramova

Authors
  1. N. V. Menshutina
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  2. A. A. Uvarova
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  3. M. S. Mochalova
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  4. D. D. Lovskaya
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  6. O. I. Gurina
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  8. O. V. Abramova
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Correspondence to N. V. Menshutina.

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Translated by L. Smolina

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Menshutina, N.V., Uvarova, A.A., Mochalova, M.S. et al. Biopolymer Aerogels as Nasal Drug Delivery Systems. Russ. J. Phys. Chem. B 17, 1507–1518 (2023). https://doi.org/10.1134/S1990793123070163

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  • DOI: https://doi.org/10.1134/S1990793123070163

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